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B4RCZ4

- SYL_PHEZH

UniProt

B4RCZ4 - SYL_PHEZH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Phenylobacterium zucineum (strain HLK1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei630 – 6301ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPZUC450851:GHUG-3562-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PHZ_c3517
    OrganismiPhenylobacterium zucineum (strain HLK1)
    Taxonomic identifieri450851 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
    ProteomesiUP000001868: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Leucine--tRNA ligasePRO_1000199218Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi450851.PHZ_c3517.

    Structurei

    3D structure databases

    ProteinModelPortaliB4RCZ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi627 – 6315"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4RCZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATRYNPKE TEPKWRKRWD EAQAFRAVEA PGKRKYYVLE MFPYPSGRLH    50
    MGHVRNYALG DVIARYKRAQ DFSVLHPMGW DAFGLPAENA AMERGVDPKA 100
    WTYDNIARMR AELKELGLSI DWSREFATCD VEYYGQQQAL FLELFERGLV 150
    YRKESVVNWD PVDQTVLANE QVVDGKGWRS GAPVEKRKLA QWFLKITQYA 200
    DQLVDDLKTL DRWPEKVRVM QENWIGRSKG ARLRFRFAGQ PPAGHEAGVE 250
    VYTTRPDTLF GASFVGVAPD HPLAQAVAAA NPEAAAFIEK CRHGAVSEAE 300
    IETAEKEGFD TGLKVKHPFD PSWELPVWIA NFILMDYGTG AIFGCPAHDQ 350
    RDLDFARKYG LPVKPVVLPP EEAQAEAIVQ KLLNEAYTGP GRIINSGFLD 400
    GLDVEAAKAA AIARIEEQGD GQGATVYRLR DWGVSRQRAW GCPIPVVHCQ 450
    ACGVVPVRRS DLPLTHPADI EFGKAGNALE RHPTWKHTTC PGCGGPATRE 500
    TDTLDTFVDS SWYFARFANP GAEAPIDKAA ADYWLPVDQY IGGVEHAVLH 550
    LLYARFITKA LADVGMLSVR EPFAGLFTQG MVTHETYRKQ SGEWVEPKEV 600
    EVTAEGKTRR ARLVGSGEPV VIGDVEKMSK SKKNTVAPEE IFDVYGVDAA 650
    RLFVLSDSPP ERDAQWSTSG VQGAWRFVNR VWDEFDASEE PVPGTEEAVT 700
    GVATDNLRRQ HAKTVKAVTE AIEGFRFNSA IAHLYSFLNV LKAERPQGRA 750
    GALAHAHRAA LRDFALLIAP FTPHLAEECW ARIGGQGLVV EAPWPTYDPA 800
    LTQDAVKVLP VQVNGKRRGE ISAPAGAEPA EVEQLVLADP EIKARLEGLT 850
    IRKIIVVKDR IVNIVAA 867
    Length:867
    Mass (Da):96,158
    Last modified:September 23, 2008 - v1
    Checksum:iA803FE1B482BC32A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000747 Genomic DNA. Translation: ACG79926.1.
    RefSeqiYP_002132355.1. NC_011144.1.

    Genome annotation databases

    EnsemblBacteriaiACG79926; ACG79926; PHZ_c3517.
    GeneIDi6789470.
    KEGGipzu:PHZ_c3517.
    PATRICi22930436. VBIPheZuc44517_4272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000747 Genomic DNA. Translation: ACG79926.1 .
    RefSeqi YP_002132355.1. NC_011144.1.

    3D structure databases

    ProteinModelPortali B4RCZ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 450851.PHZ_c3517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG79926 ; ACG79926 ; PHZ_c3517 .
    GeneIDi 6789470.
    KEGGi pzu:PHZ_c3517.
    PATRICi 22930436. VBIPheZuc44517_4272.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PZUC450851:GHUG-3562-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562."
      Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.
      BMC Genomics 9:386-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HLK1.

    Entry informationi

    Entry nameiSYL_PHEZH
    AccessioniPrimary (citable) accession number: B4RCZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3