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B4RCZ4

- SYL_PHEZH

UniProt

B4RCZ4 - SYL_PHEZH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Phenylobacterium zucineum (strain HLK1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPZUC450851:GHUG-3562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PHZ_c3517
OrganismiPhenylobacterium zucineum (strain HLK1)
Taxonomic identifieri450851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
ProteomesiUP000001868: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Leucine--tRNA ligasePRO_1000199218Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi450851.PHZ_c3517.

Structurei

3D structure databases

ProteinModelPortaliB4RCZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi627 – 6315"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4RCZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATRYNPKE TEPKWRKRWD EAQAFRAVEA PGKRKYYVLE MFPYPSGRLH
60 70 80 90 100
MGHVRNYALG DVIARYKRAQ DFSVLHPMGW DAFGLPAENA AMERGVDPKA
110 120 130 140 150
WTYDNIARMR AELKELGLSI DWSREFATCD VEYYGQQQAL FLELFERGLV
160 170 180 190 200
YRKESVVNWD PVDQTVLANE QVVDGKGWRS GAPVEKRKLA QWFLKITQYA
210 220 230 240 250
DQLVDDLKTL DRWPEKVRVM QENWIGRSKG ARLRFRFAGQ PPAGHEAGVE
260 270 280 290 300
VYTTRPDTLF GASFVGVAPD HPLAQAVAAA NPEAAAFIEK CRHGAVSEAE
310 320 330 340 350
IETAEKEGFD TGLKVKHPFD PSWELPVWIA NFILMDYGTG AIFGCPAHDQ
360 370 380 390 400
RDLDFARKYG LPVKPVVLPP EEAQAEAIVQ KLLNEAYTGP GRIINSGFLD
410 420 430 440 450
GLDVEAAKAA AIARIEEQGD GQGATVYRLR DWGVSRQRAW GCPIPVVHCQ
460 470 480 490 500
ACGVVPVRRS DLPLTHPADI EFGKAGNALE RHPTWKHTTC PGCGGPATRE
510 520 530 540 550
TDTLDTFVDS SWYFARFANP GAEAPIDKAA ADYWLPVDQY IGGVEHAVLH
560 570 580 590 600
LLYARFITKA LADVGMLSVR EPFAGLFTQG MVTHETYRKQ SGEWVEPKEV
610 620 630 640 650
EVTAEGKTRR ARLVGSGEPV VIGDVEKMSK SKKNTVAPEE IFDVYGVDAA
660 670 680 690 700
RLFVLSDSPP ERDAQWSTSG VQGAWRFVNR VWDEFDASEE PVPGTEEAVT
710 720 730 740 750
GVATDNLRRQ HAKTVKAVTE AIEGFRFNSA IAHLYSFLNV LKAERPQGRA
760 770 780 790 800
GALAHAHRAA LRDFALLIAP FTPHLAEECW ARIGGQGLVV EAPWPTYDPA
810 820 830 840 850
LTQDAVKVLP VQVNGKRRGE ISAPAGAEPA EVEQLVLADP EIKARLEGLT
860
IRKIIVVKDR IVNIVAA
Length:867
Mass (Da):96,158
Last modified:September 23, 2008 - v1
Checksum:iA803FE1B482BC32A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000747 Genomic DNA. Translation: ACG79926.1.
RefSeqiYP_002132355.1. NC_011144.1.

Genome annotation databases

EnsemblBacteriaiACG79926; ACG79926; PHZ_c3517.
GeneIDi6789470.
KEGGipzu:PHZ_c3517.
PATRICi22930436. VBIPheZuc44517_4272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000747 Genomic DNA. Translation: ACG79926.1 .
RefSeqi YP_002132355.1. NC_011144.1.

3D structure databases

ProteinModelPortali B4RCZ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 450851.PHZ_c3517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG79926 ; ACG79926 ; PHZ_c3517 .
GeneIDi 6789470.
KEGGi pzu:PHZ_c3517.
PATRICi 22930436. VBIPheZuc44517_4272.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PZUC450851:GHUG-3562-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562."
    Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.
    BMC Genomics 9:386-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLK1.

Entry informationi

Entry nameiSYL_PHEZH
AccessioniPrimary (citable) accession number: B4RCZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3