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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Phenylobacterium zucineum (strain HLK1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPZUC450851:GHUG-3562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PHZ_c3517
OrganismiPhenylobacterium zucineum (strain HLK1)
Taxonomic identifieri450851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
ProteomesiUP000001868 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Leucine--tRNA ligasePRO_1000199218Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi450851.PHZ_c3517.

Structurei

3D structure databases

ProteinModelPortaliB4RCZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi627 – 6315"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4RCZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATRYNPKE TEPKWRKRWD EAQAFRAVEA PGKRKYYVLE MFPYPSGRLH
60 70 80 90 100
MGHVRNYALG DVIARYKRAQ DFSVLHPMGW DAFGLPAENA AMERGVDPKA
110 120 130 140 150
WTYDNIARMR AELKELGLSI DWSREFATCD VEYYGQQQAL FLELFERGLV
160 170 180 190 200
YRKESVVNWD PVDQTVLANE QVVDGKGWRS GAPVEKRKLA QWFLKITQYA
210 220 230 240 250
DQLVDDLKTL DRWPEKVRVM QENWIGRSKG ARLRFRFAGQ PPAGHEAGVE
260 270 280 290 300
VYTTRPDTLF GASFVGVAPD HPLAQAVAAA NPEAAAFIEK CRHGAVSEAE
310 320 330 340 350
IETAEKEGFD TGLKVKHPFD PSWELPVWIA NFILMDYGTG AIFGCPAHDQ
360 370 380 390 400
RDLDFARKYG LPVKPVVLPP EEAQAEAIVQ KLLNEAYTGP GRIINSGFLD
410 420 430 440 450
GLDVEAAKAA AIARIEEQGD GQGATVYRLR DWGVSRQRAW GCPIPVVHCQ
460 470 480 490 500
ACGVVPVRRS DLPLTHPADI EFGKAGNALE RHPTWKHTTC PGCGGPATRE
510 520 530 540 550
TDTLDTFVDS SWYFARFANP GAEAPIDKAA ADYWLPVDQY IGGVEHAVLH
560 570 580 590 600
LLYARFITKA LADVGMLSVR EPFAGLFTQG MVTHETYRKQ SGEWVEPKEV
610 620 630 640 650
EVTAEGKTRR ARLVGSGEPV VIGDVEKMSK SKKNTVAPEE IFDVYGVDAA
660 670 680 690 700
RLFVLSDSPP ERDAQWSTSG VQGAWRFVNR VWDEFDASEE PVPGTEEAVT
710 720 730 740 750
GVATDNLRRQ HAKTVKAVTE AIEGFRFNSA IAHLYSFLNV LKAERPQGRA
760 770 780 790 800
GALAHAHRAA LRDFALLIAP FTPHLAEECW ARIGGQGLVV EAPWPTYDPA
810 820 830 840 850
LTQDAVKVLP VQVNGKRRGE ISAPAGAEPA EVEQLVLADP EIKARLEGLT
860
IRKIIVVKDR IVNIVAA
Length:867
Mass (Da):96,158
Last modified:September 23, 2008 - v1
Checksum:iA803FE1B482BC32A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000747 Genomic DNA. Translation: ACG79926.1.
RefSeqiWP_012524064.1. NC_011144.1.
YP_002132355.1. NC_011144.1.

Genome annotation databases

EnsemblBacteriaiACG79926; ACG79926; PHZ_c3517.
KEGGipzu:PHZ_c3517.
PATRICi22930436. VBIPheZuc44517_4272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000747 Genomic DNA. Translation: ACG79926.1.
RefSeqiWP_012524064.1. NC_011144.1.
YP_002132355.1. NC_011144.1.

3D structure databases

ProteinModelPortaliB4RCZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi450851.PHZ_c3517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG79926; ACG79926; PHZ_c3517.
KEGGipzu:PHZ_c3517.
PATRICi22930436. VBIPheZuc44517_4272.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciPZUC450851:GHUG-3562-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562."
    Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.
    BMC Genomics 9:386-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLK1.

Entry informationi

Entry nameiSYL_PHEZH
AccessioniPrimary (citable) accession number: B4RCZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: May 27, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.