Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B4RCI1

- UPPP_PHEZH

UniProt

B4RCI1 - UPPP_PHEZH

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Phenylobacterium zucineum (strain HLK1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciPZUC450851:GHUG-168-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:PHZ_c0166
    OrganismiPhenylobacterium zucineum (strain HLK1)
    Taxonomic identifieri450851 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
    ProteomesiUP000001868: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatasePRO_1000197387Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi450851.PHZ_c0166.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei80 – 10021HelicalUniRule annotationAdd
    BLAST
    Transmembranei105 – 12521HelicalUniRule annotationAdd
    BLAST
    Transmembranei139 – 15921HelicalUniRule annotationAdd
    BLAST
    Transmembranei182 – 20221HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei245 – 26521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiWRKISSS.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4RCI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDWVLAIIL GVVEGLTEFI PVSSTGHILL LGHFLGFHST GKVFEVMIQL    50
    GAILAVISVY FGRLWSVATH LHTDPAARRF VASIVLAFLP AGFAGFLLHD 100
    YIKAVLFETP AVICVSLILG GFALLAVDRI QREPVYTDAG AFPLKTAFII 150
    GLFQCLALIP GVSRSGATVA GALLMRCDKR SAAEFSFFLA MPTMAGAFTV 200
    DLAKNYKLLS ADDAGIIALG FVCALVAAII TVRKVVDFVG RHGFAPFAWW 250
    RIAVGALGLL GLAFIG 266
    Length:266
    Mass (Da):28,310
    Last modified:September 23, 2008 - v1
    Checksum:i5548EB82DAB83AD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000747 Genomic DNA. Translation: ACG76580.1.
    RefSeqiWP_012520728.1. NC_011144.1.
    YP_002129009.1. NC_011144.1.

    Genome annotation databases

    EnsemblBacteriaiACG76580; ACG76580; PHZ_c0166.
    GeneIDi6789654.
    KEGGipzu:PHZ_c0166.
    PATRICi22922856. VBIPheZuc44517_0525.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000747 Genomic DNA. Translation: ACG76580.1 .
    RefSeqi WP_012520728.1. NC_011144.1.
    YP_002129009.1. NC_011144.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 450851.PHZ_c0166.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG76580 ; ACG76580 ; PHZ_c0166 .
    GeneIDi 6789654.
    KEGGi pzu:PHZ_c0166.
    PATRICi 22922856. VBIPheZuc44517_0525.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi WRKISSS.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci PZUC450851:GHUG-168-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562."
      Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.
      BMC Genomics 9:386-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HLK1.

    Entry informationi

    Entry nameiUPPP_PHEZH
    AccessioniPrimary (citable) accession number: B4RCI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3