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B4RB19 (B4RB19_PHEZH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ACG78070.1
Ordered Locus Names:PHZ_c1659
OrganismPhenylobacterium zucineum (strain HLK1) [Complete proteome] [HAMAP]
Taxonomic identifier450851 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Phenylobacterium

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region254 – 2585ACP-binding By similarity HAMAP MF_01815

Sites

Active site1161 By similarity HAMAP MF_01815
Active site2531 By similarity HAMAP MF_01815
Active site2831 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B4RB19 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 15956EF13F8CED41

FASTA32634,432
        10         20         30         40         50         60 
MPKVLRSVVT GVGGYLPERI VTNDDLAKIV ETSDEWIRER TGIRQRRQAE DDQPVSDLAV 

        70         80         90        100        110        120 
EAARRALAAA GRSPDDVDLI VVATTTPDLT FPATAAIVQR KLGAPVGIAF DVQAVCSGFV 

       130        140        150        160        170        180 
YALSVADGFV ARRRAKCALV IGAECMTRLM DWTDRGTCVL FGDGAGAVVL EPGEGEGAVA 

       190        200        210        220        230        240 
DRGLLGFALR ADGTKQDLLY VDGGVSTTRT TGYLRMQGNQ VFRHAVVNIS EAVVAAAADA 

       250        260        270        280        290        300 
GVEVSAVDWF IPHQANQRIL EGVARRLGID ETKVISTVAE HANTSAASIP LALDQGVQDG 

       310        320 
RIKPGQLLLL EAMGGGLTWG ACVLRL

« Hide

References

[1]"Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562."
Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.
BMC Genomics 9:386-386(2008) [PubMed: 18700039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000747 Genomic DNA. Translation: ACG78070.1.
RefSeqYP_002130499.1. NC_011144.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB4RB19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6791171.
GenomeReviewsGene locus PHZ_c1659 in contig CP000747_GR.
KEGGpzu:PHZ_c1659.
PATRIC22926242. VBIPheZuc44517_2194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMADAYIRGG.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB4RB19_PHEZH
AccessionPrimary (citable) accession number: B4RB19
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info