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B4R9C7

- B4R9C7_PHEZH

UniProt

B4R9C7 - B4R9C7_PHEZH

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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Phenylobacterium zucineum (strain HLK1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium ions per tetramer.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi464 – 4641MagnesiumUniRule annotation
Metal bindingi470 – 4701Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi473 – 4731MagnesiumUniRule annotation
Metal bindingi474 – 4741MagnesiumUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
  2. tRNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPZUC450851:GHUG-3018-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotationSAAS annotation (EC:6.1.1.20UniRule annotationSAAS annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Gene namesi
Name:pheTUniRule annotationImported
Ordered Locus Names:PHZ_c2978Imported
OrganismiPhenylobacterium zucineum (strain HLK1)Imported
Taxonomic identifieri450851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
ProteomesiUP000001868: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi450851.PHZ_c2978.

Structurei

3D structure databases

ProteinModelPortaliB4R9C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 148110tRNA-bindingUniRule annotationAdd
BLAST
Domaini415 – 48672B5UniRule annotationAdd
BLAST
Domaini713 – 80694FDX-ACBUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotation
Contains 1 B5 domain.UniRule annotation
Contains 1 FDX-ACB domain.UniRule annotation
Contains 1 tRNA-binding domain.UniRule annotation
Contains B5 domain.SAAS annotation
Contains Bdomain.SAAS annotation
Contains FDX-ACB domain.SAAS annotation
Contains tRNA-binding domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0072.
HOGENOMiHOG000292085.
KOiK01890.
OMAiIYVFPAD.
OrthoDBiEOG6CCH1J.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPiMF_00283. Phe_tRNA_synth_beta1.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
PROSITEiPS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4R9C7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFTLSWLKE HLETDATVEQ VVEAMTMAGL EVESVEDPAA KLAKFTVAKI
60 70 80 90 100
VEAVQHPNAD KLRVCQVDTK DGRLEIVCGA PNARAGLTTI YAPIGAYVPG
110 120 130 140 150
SGITLEPRPV RGVVSNGMLC SAKELEVAEE SDGIVELPEA LPVGASAAEA
160 170 180 190 200
FGLEAVIDFE VTPNRPDWLG VRGIARDLAA AGLGKLKPET VPQVKGSFPC
210 220 230 240 250
PVEIRVDGTA CPVFGGRLIR GVKNGPSPEW LQKRLASVGL RPINALVDIT
260 270 280 290 300
NFITHDRARP LHVYDRALMV GDVIEARLGK GPAEPSATDA ASPAAHKDEQ
310 320 330 340 350
LIALDGKTYD LTPEMSIIAD ADGQRPIGLG GVMGGESTGC SETTTDVFVE
360 370 380 390 400
CAWFDPIVTA QTGRITGINS DAQYRFARGV DPQSVVPGLE LATAMILELC
410 420 430 440 450
GGEASEIRLA GEAPAPPAPI AFDRAYVKKL AGLDLPAQRI DAILTDLGFE
460 470 480 490 500
VAGNAVTPPS WRRDVEGKAD LVEEVARIAG YDNLPTEPLP EVATPAGGVL
510 520 530 540 550
TLRQRRLRDA RRSLAARGYS EAITWSFMRR AFAELFGGGQ AELVLANPIA
560 570 580 590 600
SDLDCMRPSA LGNLIEAAAR NARRGFPDAA LFEAGPNFRG DAPGDQWTAV
610 620 630 640 650
TALVAPHAPK SWTKTAPDPL FALKADLIAL LDELGAPQLQ VVQGQNSPWW
660 670 680 690 700
HPGRSARLQL GPKVVVAEFG ELHPQVLKAL DAEGPMLAFE VNLDAIPEPK
710 720 730 740 750
KKGLKTRAAL ELSPLMPLKR DFAFVVSADT PAGDLVRPIL GADKQLIADV
760 770 780 790 800
RVFDVYQGPG VPEGQKSVAI EVTVQPREKT LTDAEIEALS ARIVAAAEKA

AGAKLRG
Length:807
Mass (Da):85,673
Last modified:September 23, 2008 - v1
Checksum:i02CFAD09F98C0B1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000747 Genomic DNA. Translation: ACG79387.1.
RefSeqiWP_012523525.1. NC_011144.1.
YP_002131816.1. NC_011144.1.

Genome annotation databases

EnsemblBacteriaiACG79387; ACG79387; PHZ_c2978.
GeneIDi6788926.
KEGGipzu:PHZ_c2978.
PATRICi22929242. VBIPheZuc44517_3680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000747 Genomic DNA. Translation: ACG79387.1 .
RefSeqi WP_012523525.1. NC_011144.1.
YP_002131816.1. NC_011144.1.

3D structure databases

ProteinModelPortali B4R9C7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 450851.PHZ_c2978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG79387 ; ACG79387 ; PHZ_c2978 .
GeneIDi 6788926.
KEGGi pzu:PHZ_c2978.
PATRICi 22929242. VBIPheZuc44517_3680.

Phylogenomic databases

eggNOGi COG0072.
HOGENOMi HOG000292085.
KOi K01890.
OMAi IYVFPAD.
OrthoDBi EOG6CCH1J.

Enzyme and pathway databases

BioCyci PZUC450851:GHUG-3018-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPi MF_00283. Phe_tRNA_synth_beta1.
InterProi IPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view ]
Pfami PF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
PROSITEi PS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562."
    Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.
    BMC Genomics 9:386-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLK1Imported.

Entry informationi

Entry nameiB4R9C7_PHEZH
AccessioniPrimary (citable) accession number: B4R9C7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3