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Protein

Catalase-peroxidase

Gene

katG

Organism
Phenylobacterium zucineum (strain HLK1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Transition state stabilizerUniRule annotation1
Active sitei98Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:PHZ_c2899
OrganismiPhenylobacterium zucineum (strain HLK1)
Taxonomic identifieri450851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
Proteomesi
  • UP000001868 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548581 – 745Catalase-peroxidaseAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi450851.PHZ_c2899.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4R8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDASPLSNP AKEPAALRSL LGRTNRDWWP NQLSLDILHQ HGRHGNPMGD
60 70 80 90 100
DFDYAEAFKT LDYFAVKRDL HALMTDSQPW WPADYGHYGP FFIRMAWHSA
110 120 130 140 150
GTYRTGDGRG GANSGNQRFA PLNSWPDNAN LDKARRLLWP VKKKYGAKLS
160 170 180 190 200
WADLMIMAGN VAFESMGAPV FGFGGGRADI FEPEKDVYWG TEEQWVGKGA
210 220 230 240 250
KTRIVEGKAF EDPLAAVQMG LIYVNPEGPD GSPDPWASAR DIRMTFARMG
260 270 280 290 300
MNDEETLALT AGGHTFGKCH GAGDAAKIGA EPEGADIAQQ GLGWTSSHES
310 320 330 340 350
GMGDHTITSG LEGPWTPTPI KWDMSYFHML LDYKYELVRS PAGAKQWQPV
360 370 380 390 400
NPKPEDLAPG AHSPDRRVPT MMTTADLAFA MDPEYRKIAE RFRDNPDQFA
410 420 430 440 450
DAFARAWFKL CHRDMGPKSR YLGPEVPAED LIWQDPIPPV DHPLAEAADI
460 470 480 490 500
ASLKAKLLDS GLSVADLVRT AWASAATYRG SDHRGGANGA RIRLAPQKDW
510 520 530 540 550
EVNEPEKLAR VLGVLEKVKA DFDASAGGGK KISLADLIVL GGCAGIEKAA
560 570 580 590 600
RDAGHAIEVP FAPGRTDASP EQTDVESFEV LEPKADGFRN YLQVRFSVPT
610 620 630 640 650
EELLIDRSQL LGLSAPEMTV LVGGLRVLGV NHGGSKNGVF TDRPGQLTND
660 670 680 690 700
FFVNLLDMGT AWKQVDDKAD DLFVGTCRRT HEEKWTATRT DLVFGSNSQL
710 720 730 740
RALSEVYASD DAGERFVKDF VRAWTKVMNA DRFDLPRAQR LARAA
Length:745
Mass (Da):81,913
Last modified:September 23, 2008 - v1
Checksum:i02BD6F645AFC27A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000747 Genomic DNA. Translation: ACG79308.1.
RefSeqiWP_012523446.1. NC_011144.1.

Genome annotation databases

EnsemblBacteriaiACG79308; ACG79308; PHZ_c2899.
KEGGipzu:PHZ_c2899.
PATRICi22929058. VBIPheZuc44517_3589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000747 Genomic DNA. Translation: ACG79308.1.
RefSeqiWP_012523446.1. NC_011144.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi450851.PHZ_c2899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG79308; ACG79308; PHZ_c2899.
KEGGipzu:PHZ_c2899.
PATRICi22929058. VBIPheZuc44517_3589.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PHEZH
AccessioniPrimary (citable) accession number: B4R8U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.