B4R8T4 (KHSE_PHEZH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	PHZ_c2890

Organism

Phenylobacterium zucineum (strain HLK1) [Complete proteome] [HAMAP]

Taxonomic identifier

450851 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Phenylobacterium

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Homoserine kinase HAMAP MF_00301		PRO_1000115437

Sequences

	Sequence		Length	Mass (Da)
	B4R8T4 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 0F87BBA2DE8E3547	FASTA	323	35,333
	10 20 30 40 50 60 MAVYTDITDD ELAKLLADFD LGAPLSFKGI AEGVENSNFL LETEGGRFIL TVYEKRVRAE 70 80 90 100 110 120 DLPFFLGLMR WLSEHGFASG LPMADRGGEM LKTVRGKPCA IVSFLPGLSV RRPTVAHCRE 130 140 150 160 170 180 AGKGLAALHN AADGFPMRRE NDLGQGAWAP MFERLKDDAE RLKPGLAEVI ARDVADLADR 190 200 210 220 230 240 WPQGLPEGVI HADYFPDNVF FKEGVFAGAI DFYFACNDIR AYDIAVALNA WCFEADGSFN 250 260 270 280 290 300 ITAARALVAG YEAVRPLSEA ERAALPVLAH GAALRFFLTR LHDWHATPAG ALVKPKDPLE 310 320 YERKLAVHRT SPDLVLFGAA AAE

References

[1]

"Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562." Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X. BMC Genomics 9:386-386(2008) [PubMed: 18700039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HLK1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000747 Genomic DNA. Translation: ACG79299.1.
RefSeq	YP_002131728.1. NC_011144.1.
3D structure databases
ProteinModelPortal	B4R8T4.
ModBase	Search...
Protein-protein interaction databases
STRING	B4R8T4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6788837.
GenomeReviews	Gene locus PHZ_c2890 in contig CP000747_GR.
KEGG	pzu:PHZ_c2890.
PATRIC	22929032. VBIPheZuc44517_3576.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_PHEZH

Accession

Primary (citable) accession number: B4R8T4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program