B4R8B5 (B4R8B5_PHEZH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 1 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase 1 HAMAP MF_01123
Acyl-activating enzyme 1 HAMAP MF_01123

Gene names

Name:	acsA1 HAMAP MF_01123
Ordered Locus Names:	PHZ_c2824

Organism

Phenylobacterium zucineum (strain HLK1) [Complete proteome] [HAMAP]

Taxonomic identifier

450851 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Phenylobacterium

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	515	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	607	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	B4R8B5 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 2D35A6AB4DEDC203	FASTA	648	71,379
	10 20 30 40 50 60 MSHDQSFPPP AAWARDALVD RRRYEDLVAL EARDPDAFWR EVAGRLDWET PFTKVKDVSF 70 80 90 100 110 120 DLTDFRIRWF EDGRLNASVN CIDRHLAARG DQTAIIWEGD DPAASRRITY RELHRQVCRM 130 140 150 160 170 180 ANVLKRRGVR RGDRVTIYLP MIPEAAYAML ACARIGAIHS VVFAGFSPDS LAGRINDCDS 190 200 210 220 230 240 RLVITADEGV RGGKRVPLKA NVDEALEHAP GVETVLVVTR TGVATSLKAG RDFVYEAEAA 250 260 270 280 290 300 EVADDCPAEA MGAEDPLFIL YTSGSTGRPK GVLHTTGGYL AWAAWTHEAV FDYRPGQVYW 310 320 330 340 350 360 CTADVGWVTG HSYIVYGPLA NGATTLMFEG VPNYPSLSRC WQVIDKHQVE IFYTAPTAIR 370 380 390 400 410 420 ALMREGEAPV ARTSRRSLRL LGSVGEPINP EAWLWYHRVV GEHRCPIVDT WWQTETGGIL 430 440 450 460 470 480 ISPLPGATTL KPGSATRPLP GVKLALVDAD GRPLEGAGEG NLCLTDSWPG QMRTVWNDHE 490 500 510 520 530 540 RFLQTYFSTY PGKYFTGDGC RRDADGDYWI TGRVDDVLNV SGHRLGTAEV ESALVAHPKV 550 560 570 580 590 600 AEAAVVGFPH EVKGQGIYCY VTLKAGEQPG PALEKALVDW VRREIGPIAT PDVIQWAPGL 610 620 630 640 PKTRSGKIMR RILRKIAEGD TANLGDTSTL ADPGVVDDLV ARKRLEPA

References

[1]

"Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562." Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X. BMC Genomics 9:386-386(2008) [PubMed: 18700039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000747 Genomic DNA. Translation: ACG79233.1.
RefSeq	YP_002131662.1. NC_011144.1.
3D structure databases
ProteinModelPortal	B4R8B5.
ModBase	Search...
Protein-protein interaction databases
STRING	B4R8B5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6788770.
GenomeReviews	Gene locus PHZ_c2824 in contig CP000747_GR.
KEGG	pzu:PHZ_c2824.
PATRIC	22928882. VBIPheZuc44517_3502.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	KGKPYML.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4R8B5_PHEZH

Accession

Primary (citable) accession number: B4R8B5

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)