ID B4R724_DROSI Unreviewed; 1262 AA. AC B4R724; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 27-MAR-2024, entry version 97. DE SubName: Full=GD16494 {ECO:0000313|EMBL:EDX16735.1}; GN Name=Dsim\GD16494 {ECO:0000313|EMBL:EDX16735.1}; GN ORFNames=Dsim_GD16494 {ECO:0000313|EMBL:EDX16735.1}; OS Drosophila simulans (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX16735.1, ECO:0000313|Proteomes:UP000000304}; RN [1] {ECO:0000313|EMBL:EDX16735.1, ECO:0000313|Proteomes:UP000000304} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=mosaic {ECO:0000313|Proteomes:UP000000304}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M., RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CM000366; EDX16735.1; -; Genomic_DNA. DR AlphaFoldDB; B4R724; -. DR SMR; B4R724; -. DR STRING; 7240.B4R724; -. DR HOGENOM; CLU_003399_0_0_1; -. DR OMA; RMTHWES; -. DR PhylomeDB; B4R724; -. DR Proteomes; UP000000304; Chromosome x. DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt. DR GO; GO:0002039; F:p53 binding; IEA:InterPro. DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2. DR Gene3D; 2.170.270.10; SET domain; 2. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR043550; EHMT1/EHMT2. DR InterPro; IPR007728; Pre-SET_dom. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR PANTHER; PTHR46307; G9A, ISOFORM B; 1. DR PANTHER; PTHR46307:SF4; G9A, ISOFORM B; 1. DR Pfam; PF00023; Ank; 1. DR Pfam; PF12796; Ank_2; 2. DR Pfam; PF05033; Pre-SET; 1. DR Pfam; PF00856; SET; 1. DR PRINTS; PR01415; ANKYRIN. DR SMART; SM00248; ANK; 6. DR SMART; SM00468; PreSET; 1. DR SMART; SM00317; SET; 1. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR SUPFAM; SSF82199; SET domain; 1. DR PROSITE; PS50297; ANK_REP_REGION; 3. DR PROSITE; PS50088; ANK_REPEAT; 4. DR PROSITE; PS50867; PRE_SET; 1. DR PROSITE; PS50280; SET; 1. PE 4: Predicted; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Reference proteome {ECO:0000313|Proteomes:UP000000304}. FT REPEAT 800..822 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 843..875 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 876..909 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 910..942 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT DOMAIN 1041..1112 FT /note="Pre-SET" FT /evidence="ECO:0000259|PROSITE:PS50867" FT DOMAIN 1044..1203 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT REGION 48..73 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 91..206 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 236..296 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 312..386 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 457..517 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 541..587 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1229..1262 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..73 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 91..138 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 172..191 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 236..254 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 275..296 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 315..329 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 360..379 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 483..502 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 503..517 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 551..568 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1262 AA; 138803 MW; F0B058FFBB77BC9A CRC64; MTDFVELMNS MSSTFNSDCA TSTAEGGTLL NMNLAEDKTL KWRNLANNQF ASKEKKHKDK EEERKEARNQ EEIEDIKALL ADVVDAAAVK LEEEEAQNAE KVEQHTKSEK EEEGRKEMEY DQDVAKQYSE KEEKQNGKAT SITVKMESNE RAEKHATEIA TTSTDRWQNE SFKTEQQNKK AAEKEEDTLA ATQKSDANAD PGTKTRIEAA VASPLVVSSA SVKLAADATN QMRAATSTGA ATLADKNVQV SPGGTRRSRR APRPPDTPTS VTDEHVQVEN KKFGKSEQYT DCSSHLERFT LDDNTAIVRL QLKSELDKPS STTLSPEENS APAPKRGRGR ARKIRPDAEV ETSEVILPCE DSLGEKKPGR KRKLPDEPID QQQLSDFVVV KTEQEELGEA PLGDVKRMRR SVRLGNRLHA DGSPWEEVKT EALPSQPSAE LSLAEVTSEV LPLAVLDEKT PPKKRGRKAK TPGVKLESET SCVLPFANGN KKTNSSGGSE LQLPKRSKRR IKPTPKILEN DELRCEFETK HIERMTHWES AAAVDGDFET PTTGGNGSNS STSRQKSDKS DGSNFEGGPG HPAGTSAIKK RLFSKSQRDI ENYGAAMLAK IGKANTPGAT ARNNGGPSTA VTLSAALIPA SKTNGAQSGR AGTSNSSSGH ALNSINFAQL IPESVMNVVL RGHVVSASGR VTTEFTPRDM YYAVQNDDLE RVAEILAADF NVLTPIREYL NGTCLHLVAH SGTLQMAYLL LCKGASSPDF VNIVDYELRT ALMCAVMNEK CDMLNLFLQC GADVAIKGPD GKTSLHIAAQ LGNLEATQLI VDSYRTSRNI TSFLSFIDAQ DEGGWTAMVW AAELGHTDIV SFLLNQDADP NICDNDNNTV LHWSTLHNDG LDTITVLLQS GADCNVQNVE GDTPLHIACR HSVTRMCIAL IANGADLMIK NKAEQLPFDC IPNEESECGR TVGFNMQMRS FRPLGLRTFV VCADASNGRE ARPIQVVRNE LAMSENEDEA DSLMWPDFRY VTQCIIQQNS VQIDRRVSQM RICSCLDSCS SDRCQCNGAS SQNWYTAESR LTADFNYEDP AVIFECNDVC GCNQMGTPDT TYICRVREIQ AKGLGDTGAL PHVHTEPSFV RRTDDSYYFD LDNGHCIDAN YYGNVTRFFN HSCEPNVLPV RVFYEHQDYR FPKIAFFSCR DIDAGEEICF DYGEKFWRVE HRSCVGCRCL SATCKYASQS SSTNASPTDA TTAPENETGT LSSTNTEKIG QA //