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B4R313

- PGAM5_DROSI

UniProt

B4R313 - PGAM5_DROSI

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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homologBy similarity
Gene namesi
Name:Pgam5By similarity
ORF Names:GD16411
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome X, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0188028. Dsim\GD16411.

Subcellular locationi

Mitochondrion outer membrane By similaritySequence Analysis; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390709Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4R313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK15637.
OrthoDBiEOG7966H1.
PhylomeDBiB4R313.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

B4R313-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKLTSFACG TGAGLAAYYL QRLRDPQTAV QNSWTHSDKP VDPWALWDTN
60 70 80 90 100
WDCREPRALV RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV
110 120 130 140 150
GDSDDTHHLT ERGRKQAEFT GKRLCELGIK WDKVVASTML RAQETSDIIL
160 170 180 190 200
KQIDFEKEKV VNCAFLREGA PIPPQPPVGH WKPEASQFLR DGSRIEAGFR
210 220 230 240 250
RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW LRININHASI
260 270 280
TWLTISPSGN VSIKYLGDSG FMPAELLTNR IPRDVKNVV
Length:289
Mass (Da):33,124
Last modified:September 23, 2008 - v1
Checksum:iDD65BD12D509B922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000366 Genomic DNA. Translation: EDX16867.1.
RefSeqiXP_002105926.1. XM_002105890.1.

Genome annotation databases

EnsemblMetazoaiFBtr0216321; FBpp0214813; FBgn0188028.
GeneIDi6724888.
KEGGidsi:Dsim_GD16411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000366 Genomic DNA. Translation: EDX16867.1 .
RefSeqi XP_002105926.1. XM_002105890.1.

3D structure databases

ProteinModelPortali B4R313.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0216321 ; FBpp0214813 ; FBgn0188028 .
GeneIDi 6724888.
KEGGi dsi:Dsim_GD16411.

Organism-specific databases

FlyBasei FBgn0188028. Dsim\GD16411.

Phylogenomic databases

KOi K15637.
OrthoDBi EOG7966H1.
PhylomeDBi B4R313.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPGAM5_DROSI
AccessioniPrimary (citable) accession number: B4R313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3