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Protein

Alkaline phosphatase

Gene

Dsim\GD21558

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.UniRule annotation

GO - Molecular functioni

  1. alkaline phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesi
Name:Dsim\GD21558Imported
ORF Names:Dsim_GD21558Imported, GD21558Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0083464. Dsim\GD21558.

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.UniRule annotation

Phylogenomic databases

KOiK01077.
OrthoDBiEOG7SN8CH.
PhylomeDBiB4R2C7.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4R2C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLVILGLL LGGLVAISWA GVTTQPPPLI RTLSAGGDIG PQFDVGKPKE
60 70 80 90 100
PEDAEFWHKV GLRQLEKTIK HAQRLKEDSY QKKARNIIIF IGDGMGISTI
110 120 130 140 150
SAGRIYKGQY LKHGYGEEET LIFDDFPNTG MAKTYNVDKQ VPDSAGTATA
160 170 180 190 200
IFSGSKTHYG AIGMDATRSK KNGQQGRVQS VMEWAQKEGK RTGVVTTTRI
210 220 230 240 250
THATPAATYA HIYDRDWECD TEVPAESVGY HVDIARQLVE NAPGNRFNVI
260 270 280 290 300
LGGGMSPMGI LNASEVKTTI FEGPTETICS RGDNRNLPAE WLAHHANDTV
310 320 330 340 350
PPALVHNRRD LLNVNVKKVD HLMGLFRNNH ITYSIAREAG EPSLQEMTET
360 370 380 390 400
ALGILERGDE SNGYVLLVEG GRIDQGHHMN YARAALHELY EFDLAIQAAV
410 420 430 440 450
NNTDPDETLI LVTADHSHAV TFNGYALRGA DILGTANSHE KNDPMFYETI
460 470 480 490 500
SYANGPGYWD HLANDSRPQN SSNMWMPLKH FTAEERAAPT YRHLATVPRK
510 520 530 540 550
DETHGGEDVA VFAYGPGSSL IRGVFEQNYL AYVMSYAGCL GPAKDFDDSC
560 570 580 590
EDHKDGQKER PLDKPNPKRS GASVVGASLI PILTAATAAI LRGHGL
Length:596
Mass (Da):65,195
Last modified:September 23, 2008 - v1
Checksum:i4905F66ED7B76AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX15083.1.
RefSeqiXP_002105580.1. XM_002105544.1.
UniGeneiDsi.163.

Genome annotation databases

EnsemblMetazoaiFBtr0221468; FBpp0219960; FBgn0083464.
GeneIDi6730297.
KEGGidsi:Dsim_GD21558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX15083.1.
RefSeqiXP_002105580.1. XM_002105544.1.
UniGeneiDsi.163.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0221468; FBpp0219960; FBgn0083464.
GeneIDi6730297.
KEGGidsi:Dsim_GD21558.

Organism-specific databases

FlyBaseiFBgn0083464. Dsim\GD21558.

Phylogenomic databases

KOiK01077.
OrthoDBiEOG7SN8CH.
PhylomeDBiB4R2C7.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MixedImported.

Entry informationi

Entry nameiB4R2C7_DROSI
AccessioniPrimary (citable) accession number: B4R2C7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.