SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4R0A5

- DGKH_DROSI

UniProt

B4R0A5 - DGKH_DROSI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Diacylglycerol kinase eta

Gene
GD19954
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) By similarity.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Gene namesi
ORF Names:GD19954
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 3R, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0191437. Dsim\GD19954.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19051905Diacylglycerol kinase etaPRO_0000375990Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHAdd
BLAST
Domaini350 – 486137DAGKcAdd
BLAST
Domaini1842 – 190564SAMAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4R0A5-1 [UniParc]FASTAAdd to Basket

« Hide

MSHLKLDTLH VQRSPRGSRR SSRSSGRSSA CSSGSISPVP IIPIISISHD     50
GDESESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR 100
RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT 150
RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA 200
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC 300
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST 500
EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH 550
HKDDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLIARSI 600
PVTPGSNAYL LNPNISIEKT EKDQINSKER RNSRSLRSSE KEALQCRANS 650
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTNASG ESTPCTSPLP 700
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS 750
RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG 800
ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFEQKEN DKEKDKPVEI 850
DMERDTCVEK DGSVPEEKLV HTCNIQVPGV VVTPNPQNVY SSASITIIDT 900
DAQTTTEQSS SDDLGGEASD VLSAISNEEC SVASEIFDKQ DAGQTVGDII 950
QNMDASNFTH IDSPETSDET EAMPGESIMD DISSVLGHDI TYALQDNTLT 1000
DDTTTLCSEH VGPPKPPRKK SLSALSRTQA HPRRRNSSPP RIARLARMDS 1050
DDNPQQFGFE NIVFEIDNRC DDQKMREPPR YCSLAQFVEG NDIARQSFKQ 1100
LMLEQHRGED NDSEYPEHQQ TPTNKGANLL ATTSEDELST QTAIKIEIQD 1150
IDATVRNLNS SMKPNTILTT STSPTKKSGH GQDISVVVRP PTPLRGDSIK 1200
PTVSLLPVSS GGAMAVSMTC SGMLGVRAMN ASEIRRHSSH APGLAVREFD 1250
KDKDRRHSGF NPNQLTLDPE HARFLSSSPA ASRRISCGSL FKVKNKKIAT 1300
KRSYGLFSVR FFVVAEPDFR LATLALIRPL IPLPNEALPN LQTLKGSKSS 1350
LFMGSTLFGF DHLASAERDK EEKGGKDKEK TPTEETNRKL PIINPLVRLP 1400
NWPNLANGGG FISKCLLANA DTLCAAVSPL MDPDETLLAG YHEKCVMNNY 1450
FGIGIDAKIS LDFHNKREEH PEKCRSRARN YMWYGVLGSK QLLQKTCKNL 1500
EQRVQLECDG QRIPLPELQG IVILNIPSFM GGTNFWGSST KKDDIFLPPS 1550
FDDRVLEVVA VFGSVQMAAS RLINLQHHRI AQCQSVQINI LGDEEIPIQV 1600
DGEAWLQPPG MIRILHKNRV QMLCRNRSLE LSLKSWQEKQ RQHSISIQRD 1650
ASSTASEHAN STDEVISERE CYVLLNFIEA VSSLVKWVKF LIISHPALQH 1700
DLYEVACRAS EALESIHPQG KLLEGPSLRT KLVEVIDSSR QLYDDACTLL 1750
RDRGHSLILR EDLETKLSAA LANMEMELKK CSVQKCIDGK LRAYFNVLAP 1800
NEEVDGRRKS RPFWVRLRSG STAGQQQFKP PMTNTREAAN NWSVNEVVTW 1850
LETMQLSEYV DSFLKNDIRG KELLTLGRRD LKDLGVVKVG HVKRILQAIK 1900
DLSEN 1905
Length:1,905
Mass (Da):212,678
Last modified:May 26, 2009 - v2
Checksum:iEB292E228AD94D66
GO

Sequence cautioni

The sequence EDX12030.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000364 Genomic DNA. Translation: EDX12030.1. Sequence problems.
RefSeqiXP_002102527.1. XM_002102491.1.

Genome annotation databases

GeneIDi6727134.
KEGGidsi:Dsim_GD19954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000364 Genomic DNA. Translation: EDX12030.1 . Sequence problems.
RefSeqi XP_002102527.1. XM_002102491.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6727134.
KEGGi dsi:Dsim_GD19954.

Organism-specific databases

FlyBasei FBgn0191437. Dsim\GD19954.

Phylogenomic databases

KOi K00901.
OrthoDBi EOG7DVD9B.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDGKH_DROSI
AccessioniPrimary (citable) accession number: B4R0A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi