Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B4R0A5

- DGKH_DROSI

UniProt

B4R0A5 - DGKH_DROSI

Protein

Diacylglycerol kinase eta

Gene

GD19954

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    3. protein oligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
    Short name:
    DAG kinase etaBy similarity
    Gene namesi
    ORF Names:GD19954
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000304: Chromosome 3R, UP000000304: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0191437. Dsim\GD19954.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19051905Diacylglycerol kinase etaPRO_0000375990Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 17594PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Domaini1842 – 190564SAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    KOiK00901.
    OrthoDBiEOG7DVD9B.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4R0A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHLKLDTLH VQRSPRGSRR SSRSSGRSSA CSSGSISPVP IIPIISISHD     50
    GDESESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR 100
    RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT 150
    RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA 200
    TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
    ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC 300
    LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
    NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
    HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
    WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST 500
    EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH 550
    HKDDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLIARSI 600
    PVTPGSNAYL LNPNISIEKT EKDQINSKER RNSRSLRSSE KEALQCRANS 650
    VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTNASG ESTPCTSPLP 700
    IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS 750
    RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG 800
    ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFEQKEN DKEKDKPVEI 850
    DMERDTCVEK DGSVPEEKLV HTCNIQVPGV VVTPNPQNVY SSASITIIDT 900
    DAQTTTEQSS SDDLGGEASD VLSAISNEEC SVASEIFDKQ DAGQTVGDII 950
    QNMDASNFTH IDSPETSDET EAMPGESIMD DISSVLGHDI TYALQDNTLT 1000
    DDTTTLCSEH VGPPKPPRKK SLSALSRTQA HPRRRNSSPP RIARLARMDS 1050
    DDNPQQFGFE NIVFEIDNRC DDQKMREPPR YCSLAQFVEG NDIARQSFKQ 1100
    LMLEQHRGED NDSEYPEHQQ TPTNKGANLL ATTSEDELST QTAIKIEIQD 1150
    IDATVRNLNS SMKPNTILTT STSPTKKSGH GQDISVVVRP PTPLRGDSIK 1200
    PTVSLLPVSS GGAMAVSMTC SGMLGVRAMN ASEIRRHSSH APGLAVREFD 1250
    KDKDRRHSGF NPNQLTLDPE HARFLSSSPA ASRRISCGSL FKVKNKKIAT 1300
    KRSYGLFSVR FFVVAEPDFR LATLALIRPL IPLPNEALPN LQTLKGSKSS 1350
    LFMGSTLFGF DHLASAERDK EEKGGKDKEK TPTEETNRKL PIINPLVRLP 1400
    NWPNLANGGG FISKCLLANA DTLCAAVSPL MDPDETLLAG YHEKCVMNNY 1450
    FGIGIDAKIS LDFHNKREEH PEKCRSRARN YMWYGVLGSK QLLQKTCKNL 1500
    EQRVQLECDG QRIPLPELQG IVILNIPSFM GGTNFWGSST KKDDIFLPPS 1550
    FDDRVLEVVA VFGSVQMAAS RLINLQHHRI AQCQSVQINI LGDEEIPIQV 1600
    DGEAWLQPPG MIRILHKNRV QMLCRNRSLE LSLKSWQEKQ RQHSISIQRD 1650
    ASSTASEHAN STDEVISERE CYVLLNFIEA VSSLVKWVKF LIISHPALQH 1700
    DLYEVACRAS EALESIHPQG KLLEGPSLRT KLVEVIDSSR QLYDDACTLL 1750
    RDRGHSLILR EDLETKLSAA LANMEMELKK CSVQKCIDGK LRAYFNVLAP 1800
    NEEVDGRRKS RPFWVRLRSG STAGQQQFKP PMTNTREAAN NWSVNEVVTW 1850
    LETMQLSEYV DSFLKNDIRG KELLTLGRRD LKDLGVVKVG HVKRILQAIK 1900
    DLSEN 1905
    Length:1,905
    Mass (Da):212,678
    Last modified:May 26, 2009 - v2
    Checksum:iEB292E228AD94D66
    GO

    Sequence cautioni

    The sequence EDX12030.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000364 Genomic DNA. Translation: EDX12030.1. Sequence problems.
    RefSeqiXP_002102527.1. XM_002102491.1.

    Genome annotation databases

    GeneIDi6727134.
    KEGGidsi:Dsim_GD19954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000364 Genomic DNA. Translation: EDX12030.1 . Sequence problems.
    RefSeqi XP_002102527.1. XM_002102491.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6727134.
    KEGGi dsi:Dsim_GD19954.

    Organism-specific databases

    FlyBasei FBgn0191437. Dsim\GD19954.

    Phylogenomic databases

    KOi K00901.
    OrthoDBi EOG7DVD9B.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDGKH_DROSI
    AccessioniPrimary (citable) accession number: B4R0A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3