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Protein

Protein phosphatase PTC7 homolog fig

Gene

fig

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarityCurated, Mn2+By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Manganese 1By similarity
Metal bindingi87 – 871Manganese 2By similarity
Metal bindingi88 – 881Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi232 – 2321Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog fig
Alternative name(s):
Fos intronic gene protein (EC:3.1.3.16)
Gene namesi
Name:figBy similarity
ORF Names:GD17671
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304 Componentsi: Chromosome 3R, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0189220. Dsim\GD17671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Protein phosphatase PTC7 homolog figPRO_0000377403Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB4R089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 309267PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Sequence Analysis
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK17508.
OrthoDBiEOG7DRJ3F.
PhylomeDBiB4R089.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4R089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITRMKNWPC LLKRFSIQQF HQFTHLSGRL ERAPQSGKSS RDPYLVTVVQ
60 70 80 90 100
GRSKKPRFPG ERSNQRFGED SWFVSSTPLA EVMGVADGVG GWRDLGVDAG
110 120 130 140 150
RFAKELMSCC SGQTQLSDFD GRSPRNLLIA GFQELSHREQ PVVGSSTACL
160 170 180 190 200
ATMHRKDCTL YTANLGDSGF LVVRNGRVLH RSVEQTHDFN TPYQLTVPPE
210 220 230 240 250
DRKESYYCDK PEMAVSTRHS LLPGDLVLLA TDGLFDNMPE STLLSILNGL
260 270 280 290 300
KERGERDLLE GASRVVEKAR ELSLNASFQS PFAIKARQHN VSYSGGGKPD
310
DITLILSSVE VPSV
Length:314
Mass (Da):34,834
Last modified:September 23, 2008 - v1
Checksum:i8E662288B5A5052B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX14895.1.
RefSeqiXP_002105392.1. XM_002105356.1.
UniGeneiDsi.1113.

Genome annotation databases

EnsemblMetazoaiFBtr0217581; FBpp0216073; FBgn0189220.
GeneIDi6730099.
KEGGidsi:Dsim_GD17671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX14895.1.
RefSeqiXP_002105392.1. XM_002105356.1.
UniGeneiDsi.1113.

3D structure databases

ProteinModelPortaliB4R089.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0217581; FBpp0216073; FBgn0189220.
GeneIDi6730099.
KEGGidsi:Dsim_GD17671.

Organism-specific databases

FlyBaseiFBgn0189220. Dsim\GD17671.

Phylogenomic databases

KOiK17508.
OrthoDBiEOG7DRJ3F.
PhylomeDBiB4R089.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPTC71_DROSI
AccessioniPrimary (citable) accession number: B4R089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: September 23, 2008
Last modified: April 1, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.