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B4QZU1

- PDE6_DROSI

UniProt

B4QZU1 - PDE6_DROSI

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei743 – 7431Proton donorBy similarity
    Metal bindingi747 – 7471Divalent metal cation 1By similarity
    Metal bindingi783 – 7831Divalent metal cation 1By similarity
    Metal bindingi784 – 7841Divalent metal cation 1By similarity
    Metal bindingi784 – 7841Divalent metal cation 2By similarity
    Metal bindingi894 – 8941Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GD20415
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000304: Chromosome 3R, UP000000304: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0191887. Dsim\GD20415.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11401140cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363698Add
    BLAST
    Propeptidei1141 – 11433Removed in mature formBy similarityPRO_0000363699

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1140 – 11401Cysteine methyl esterBy similarity
    Lipidationi1140 – 11401S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB4QZU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini272 – 424153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini456 – 637182GAF 2Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 4540Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    KOiK13763.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB4QZU1.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4QZU1-1 [UniParc]FASTAAdd to Basket

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    MHGPVSRSSS SSNMTDVSSP AGGAASPVEM TTSSSSAATT SASSSKPLTN     50
    GANKTTISTV AGGVAPGAVP GPGSGAIPAS SSSGNQVKLE HHHRQSNNNR 100
    PAATNRSSET KLRSPAGESD GASRLMTPAG SSSSPSQSPS QTQASIQTQT 150
    SQQDRLAKAS TTASQQDVDE VARLFEEKPE AFEKWLTERA PPEALSRLQE 200
    FIENRKPHKR PSVTSDLFQQ WMAASPTVQQ KSPRSLSNSS ASSLPECRRH 250
    LMDLDEGELF MELIRDVANE LDIDVLCHKI LVNVGLLTHA DRGSLFLAKG 300
    TPTNKYLVAK LFDVTQKTAL KDAVTRASAE EIIIPFGIGI AGMVAQTKQM 350
    INIKEAYKDA RFNCEIDLKT GYKTNAILCM PICNYEGDII GVAQIINKTN 400
    GCMEFDEHDV EIFRRYLTFC GIGIQNAQLF EMSVQEYRRN QILLNLARSI 450
    FEEQNNLECL VTKIMTEARE LLKCERCSVF LVDLDCCEAS HLEKIIEKPN 500
    QQATRAIKSA DSFEEKKMRN RFTVLFELGG EYQAANVSRP SVSELSSSTL 550
    AQIAQFVATT GQTVNICDVI EWVRDHNQIR AEDEIDSTQA ILCMPIMNAQ 600
    KKVIGVAQLI NKANGVPFTD SDASIFEAFA IFCGLGIHNT QMYENACKLM 650
    AKQKVALECL SYHATASQDQ TEKLTQDVIA EAESYNLYSF TFTDFELVDD 700
    DTCRAVLRMF MQCNLVSQFQ IPYDVLCRWV LSVRKNYRPV KYHNWRHALN 750
    VAQTMFAMLK TGKMERFMTD LEILGLLVAC LCHDLDHRGT NNAFQTKTES 800
    PLAILYTTST MEHHHFDQCV MILNSEGNNI FQALSPEDYR SVMKTVESAI 850
    LSTDLAMYFK KRNAFLELVE NGEFDWQGEE KKDLLCGMMM TACDVSAIAK 900
    PWEVQHKVAK LVADEFFDQG DLEKLQLNTQ PVAMMDRERK DELPKMQVGF 950
    IDVICLPLYR VLCDTFPWIT PLYEGTLENR RNWQDLAEKV EMGLTWIDHD 1000
    TIDKPVEEFA ACADEEIKDI EFTVTTLNCN QQSQHGSEDS HTPEHQRSGS 1050
    RLSMKKTGAL GKAVRSKLSK TLYNSMDGSK PKTSLKLLES HVSEDMDDKS 1100
    PTSPSQPQAS GSMGRMSASS STSSTGGQMV DKSKKRSKLC ALL 1143
    Length:1,143
    Mass (Da):126,868
    Last modified:September 23, 2008 - v1
    Checksum:i33060D06C24BA337
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000364 Genomic DNA. Translation: EDX12939.1.
    RefSeqiXP_002103436.1. XM_002103400.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0220325; FBpp0218817; FBgn0191887.
    GeneIDi6728084.
    KEGGidsi:Dsim_GD20415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000364 Genomic DNA. Translation: EDX12939.1 .
    RefSeqi XP_002103436.1. XM_002103400.1.

    3D structure databases

    ProteinModelPortali B4QZU1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0220325 ; FBpp0218817 ; FBgn0191887 .
    GeneIDi 6728084.
    KEGGi dsi:Dsim_GD20415.

    Organism-specific databases

    FlyBasei FBgn0191887. Dsim\GD20415.

    Phylogenomic databases

    KOi K13763.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B4QZU1.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPDE6_DROSI
    AccessioniPrimary (citable) accession number: B4QZU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3