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B4QZU1

- PDE6_DROSI

UniProt

B4QZU1 - PDE6_DROSI

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Protein
cGMP-specific 3',5'-cyclic phosphodiesterase
Gene
Pde6, GD20415
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei743 – 7431Proton donor By similarity
Metal bindingi747 – 7471Divalent metal cation 1 By similarity
Metal bindingi783 – 7831Divalent metal cation 1 By similarity
Metal bindingi784 – 7841Divalent metal cation 1 By similarity
Metal bindingi784 – 7841Divalent metal cation 2 By similarity
Metal bindingi894 – 8941Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GD20415
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 3R, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0191887. Dsim\GD20415.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11401140cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity
PRO_0000363698Add
BLAST
Propeptidei1141 – 11433Removed in mature form By similarityBy similarity
PRO_0000363699

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1140 – 11401Cysteine methyl ester By similarityBy similarity
Lipidationi1140 – 11401S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4QZU1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini272 – 424153GAF 1
Add
BLAST
Domaini456 – 637182GAF 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 4540Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4QZU1.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4QZU1-1 [UniParc]FASTAAdd to Basket

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MHGPVSRSSS SSNMTDVSSP AGGAASPVEM TTSSSSAATT SASSSKPLTN     50
GANKTTISTV AGGVAPGAVP GPGSGAIPAS SSSGNQVKLE HHHRQSNNNR 100
PAATNRSSET KLRSPAGESD GASRLMTPAG SSSSPSQSPS QTQASIQTQT 150
SQQDRLAKAS TTASQQDVDE VARLFEEKPE AFEKWLTERA PPEALSRLQE 200
FIENRKPHKR PSVTSDLFQQ WMAASPTVQQ KSPRSLSNSS ASSLPECRRH 250
LMDLDEGELF MELIRDVANE LDIDVLCHKI LVNVGLLTHA DRGSLFLAKG 300
TPTNKYLVAK LFDVTQKTAL KDAVTRASAE EIIIPFGIGI AGMVAQTKQM 350
INIKEAYKDA RFNCEIDLKT GYKTNAILCM PICNYEGDII GVAQIINKTN 400
GCMEFDEHDV EIFRRYLTFC GIGIQNAQLF EMSVQEYRRN QILLNLARSI 450
FEEQNNLECL VTKIMTEARE LLKCERCSVF LVDLDCCEAS HLEKIIEKPN 500
QQATRAIKSA DSFEEKKMRN RFTVLFELGG EYQAANVSRP SVSELSSSTL 550
AQIAQFVATT GQTVNICDVI EWVRDHNQIR AEDEIDSTQA ILCMPIMNAQ 600
KKVIGVAQLI NKANGVPFTD SDASIFEAFA IFCGLGIHNT QMYENACKLM 650
AKQKVALECL SYHATASQDQ TEKLTQDVIA EAESYNLYSF TFTDFELVDD 700
DTCRAVLRMF MQCNLVSQFQ IPYDVLCRWV LSVRKNYRPV KYHNWRHALN 750
VAQTMFAMLK TGKMERFMTD LEILGLLVAC LCHDLDHRGT NNAFQTKTES 800
PLAILYTTST MEHHHFDQCV MILNSEGNNI FQALSPEDYR SVMKTVESAI 850
LSTDLAMYFK KRNAFLELVE NGEFDWQGEE KKDLLCGMMM TACDVSAIAK 900
PWEVQHKVAK LVADEFFDQG DLEKLQLNTQ PVAMMDRERK DELPKMQVGF 950
IDVICLPLYR VLCDTFPWIT PLYEGTLENR RNWQDLAEKV EMGLTWIDHD 1000
TIDKPVEEFA ACADEEIKDI EFTVTTLNCN QQSQHGSEDS HTPEHQRSGS 1050
RLSMKKTGAL GKAVRSKLSK TLYNSMDGSK PKTSLKLLES HVSEDMDDKS 1100
PTSPSQPQAS GSMGRMSASS STSSTGGQMV DKSKKRSKLC ALL 1143
Length:1,143
Mass (Da):126,868
Last modified:September 23, 2008 - v1
Checksum:i33060D06C24BA337
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000364 Genomic DNA. Translation: EDX12939.1.
RefSeqiXP_002103436.1. XM_002103400.1.

Genome annotation databases

EnsemblMetazoaiFBtr0220325; FBpp0218817; FBgn0191887.
GeneIDi6728084.
KEGGidsi:Dsim_GD20415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000364 Genomic DNA. Translation: EDX12939.1 .
RefSeqi XP_002103436.1. XM_002103400.1.

3D structure databases

ProteinModelPortali B4QZU1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0220325 ; FBpp0218817 ; FBgn0191887 .
GeneIDi 6728084.
KEGGi dsi:Dsim_GD20415.

Organism-specific databases

FlyBasei FBgn0191887. Dsim\GD20415.

Phylogenomic databases

KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4QZU1.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPDE6_DROSI
AccessioniPrimary (citable) accession number: B4QZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi