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B4QZU1

- PDE6_DROSI

UniProt

B4QZU1 - PDE6_DROSI

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei743 – 7431Proton donorBy similarity
Metal bindingi747 – 7471Divalent metal cation 1By similarity
Metal bindingi783 – 7831Divalent metal cation 1By similarity
Metal bindingi784 – 7841Divalent metal cation 1By similarity
Metal bindingi784 – 7841Divalent metal cation 2By similarity
Metal bindingi894 – 8941Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GD20415
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 3R, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0191887. Dsim\GD20415.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11401140cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363698Add
BLAST
Propeptidei1141 – 11433Removed in mature formBy similarityPRO_0000363699

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1140 – 11401Cysteine methyl esterBy similarity
Lipidationi1140 – 11401S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4QZU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini272 – 424153GAF 1Sequence AnalysisAdd
BLAST
Domaini456 – 637182GAF 2Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 4540Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4QZU1.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4QZU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGPVSRSSS SSNMTDVSSP AGGAASPVEM TTSSSSAATT SASSSKPLTN
60 70 80 90 100
GANKTTISTV AGGVAPGAVP GPGSGAIPAS SSSGNQVKLE HHHRQSNNNR
110 120 130 140 150
PAATNRSSET KLRSPAGESD GASRLMTPAG SSSSPSQSPS QTQASIQTQT
160 170 180 190 200
SQQDRLAKAS TTASQQDVDE VARLFEEKPE AFEKWLTERA PPEALSRLQE
210 220 230 240 250
FIENRKPHKR PSVTSDLFQQ WMAASPTVQQ KSPRSLSNSS ASSLPECRRH
260 270 280 290 300
LMDLDEGELF MELIRDVANE LDIDVLCHKI LVNVGLLTHA DRGSLFLAKG
310 320 330 340 350
TPTNKYLVAK LFDVTQKTAL KDAVTRASAE EIIIPFGIGI AGMVAQTKQM
360 370 380 390 400
INIKEAYKDA RFNCEIDLKT GYKTNAILCM PICNYEGDII GVAQIINKTN
410 420 430 440 450
GCMEFDEHDV EIFRRYLTFC GIGIQNAQLF EMSVQEYRRN QILLNLARSI
460 470 480 490 500
FEEQNNLECL VTKIMTEARE LLKCERCSVF LVDLDCCEAS HLEKIIEKPN
510 520 530 540 550
QQATRAIKSA DSFEEKKMRN RFTVLFELGG EYQAANVSRP SVSELSSSTL
560 570 580 590 600
AQIAQFVATT GQTVNICDVI EWVRDHNQIR AEDEIDSTQA ILCMPIMNAQ
610 620 630 640 650
KKVIGVAQLI NKANGVPFTD SDASIFEAFA IFCGLGIHNT QMYENACKLM
660 670 680 690 700
AKQKVALECL SYHATASQDQ TEKLTQDVIA EAESYNLYSF TFTDFELVDD
710 720 730 740 750
DTCRAVLRMF MQCNLVSQFQ IPYDVLCRWV LSVRKNYRPV KYHNWRHALN
760 770 780 790 800
VAQTMFAMLK TGKMERFMTD LEILGLLVAC LCHDLDHRGT NNAFQTKTES
810 820 830 840 850
PLAILYTTST MEHHHFDQCV MILNSEGNNI FQALSPEDYR SVMKTVESAI
860 870 880 890 900
LSTDLAMYFK KRNAFLELVE NGEFDWQGEE KKDLLCGMMM TACDVSAIAK
910 920 930 940 950
PWEVQHKVAK LVADEFFDQG DLEKLQLNTQ PVAMMDRERK DELPKMQVGF
960 970 980 990 1000
IDVICLPLYR VLCDTFPWIT PLYEGTLENR RNWQDLAEKV EMGLTWIDHD
1010 1020 1030 1040 1050
TIDKPVEEFA ACADEEIKDI EFTVTTLNCN QQSQHGSEDS HTPEHQRSGS
1060 1070 1080 1090 1100
RLSMKKTGAL GKAVRSKLSK TLYNSMDGSK PKTSLKLLES HVSEDMDDKS
1110 1120 1130 1140
PTSPSQPQAS GSMGRMSASS STSSTGGQMV DKSKKRSKLC ALL
Length:1,143
Mass (Da):126,868
Last modified:September 23, 2008 - v1
Checksum:i33060D06C24BA337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX12939.1.
RefSeqiXP_002103436.1. XM_002103400.1.

Genome annotation databases

EnsemblMetazoaiFBtr0220325; FBpp0218817; FBgn0191887.
GeneIDi6728084.
KEGGidsi:Dsim_GD20415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX12939.1 .
RefSeqi XP_002103436.1. XM_002103400.1.

3D structure databases

ProteinModelPortali B4QZU1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0220325 ; FBpp0218817 ; FBgn0191887 .
GeneIDi 6728084.
KEGGi dsi:Dsim_GD20415.

Organism-specific databases

FlyBasei FBgn0191887. Dsim\GD20415.

Phylogenomic databases

KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4QZU1.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPDE6_DROSI
AccessioniPrimary (citable) accession number: B4QZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3