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Protein

Hexokinase

Gene

Hex-t1

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Hex-t1Imported
Synonyms:Dsim\Hex-t1Imported
ORF Names:Dsim_GD21281Imported, GD21281Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0042856. Dsim\Hex-t1.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

KOiK00844.
OrthoDBiEOG7TBC24.
PhylomeDBiB4QW49.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4QW49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTFNPEED FPEVYKVCKL FNPSIDDLEK IKQAMDREIT MGLSRDHHDR
60 70 80 90 100
STVPCHLSYV QDLPTGRERG QFLALEMMPT NCRIMLVKFS SERDIYTSSK
110 120 130 140 150
CVIMPHTVAA GRGTEVFTFL ATIIANFVKE KKVDKDNLPL GIAFAFTLKK
160 170 180 190 200
LALDVGILVS WTKEFGAQGA IGKDVVQLLR DALAKFPEIS VDVMGIINVG
210 220 230 240 250
AGSLLALCWA QPDTRIGLIM GSIANSCYVE RVERCETASL MKAGAIFAED
260 270 280 290 300
RRDYIGIQWK LDMVSLIEIV SDPPGVYTKA QEVMDKFRIR HCKERDLAAL
310 320 330 340 350
KYICDTVTNR AAMLVASGVS CLIDRMRLPQ ISIAVDGGIY RLHPTFATVL
360 370 380 390 400
NKYTRLLADP NYNFEFVITQ DSCGVGAAIM AGMAHANKYK TDAKLFTMDY
Length:400
Mass (Da):44,571
Last modified:September 23, 2008 - v1
Checksum:i0F377C6292150D57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX14548.1.
RefSeqiXP_002105045.1. XM_002105009.1.

Genome annotation databases

EnsemblMetazoaiFBtr0221191; FBpp0219683; FBgn0042856.
GeneIDi6729739.
KEGGidsi:Dsim_GD21281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA. Translation: EDX14548.1.
RefSeqiXP_002105045.1. XM_002105009.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0221191; FBpp0219683; FBgn0042856.
GeneIDi6729739.
KEGGidsi:Dsim_GD21281.

Organism-specific databases

FlyBaseiFBgn0042856. Dsim\Hex-t1.

Phylogenomic databases

KOiK00844.
OrthoDBiEOG7TBC24.
PhylomeDBiB4QW49.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MixedImported.

Entry informationi

Entry nameiB4QW49_DROSI
AccessioniPrimary (citable) accession number: B4QW49
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 24, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.