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B4QR82 (B4QR82_DROSI) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Subunit structure

Homooctamer By similarity.

Sequence similarities

Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
   Biological processPorphyrin biosynthesis RuleBase RU000515
   Molecular functionLyase RuleBase RU000515
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: InterPro

porphobilinogen synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1951Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Active site2481Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Metal binding1201Zinc 1; catalytic By similarity
Metal binding1221Zinc 1; catalytic By similarity
Metal binding1291Zinc 2 By similarity
Metal binding1301Zinc 1; catalytic By similarity
Metal binding2191Zinc 2 By similarity
Binding site2051Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2171Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2751Substrate 2 By similarity PIRSR PIRSR001415-2
Binding site3141Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

Sequence LengthMass (Da)Tools
B4QR82 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 3DE1871E5F5EF3ED

FASTA32735,948
        10         20         30         40         50         60 
MERKLHSGMH HATLRQLQES GCEIAPHNLM YPVFIVSNDD DVQPIASMPG ISRFGLNRLK 

        70         80         90        100        110        120 
EHLEPLVAKG LSSVLLFGVV EPDMKDEQAS NADSAKNPVV LALPKLREWF PDLLIACDVC 

       130        140        150        160        170        180 
ICPYSSHGHC GLLGETGLEN GPSIKRIAEI AVAYAKAGAH IVAPSDMMDN RVKAIKQALI 

       190        200        210        220        230        240 
DAQMNSVSLL AYSAKFTSNF YGPFREAAQS APKFGDRRCY QLPSGSRSLA MRAIQRDVAE 

       250        260        270        280        290        300 
GADMLMVKPG MPYLDILRST KDSYPYHTLY VYQVSGEFAM LYHAAKAGAF DLKDAVLEAM 

       310        320 
KGFRRAGADC IITYYTPFLL DIIGKVK 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Mixed EMBL EDX10212.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000363 Genomic DNA. Translation: EDX10212.1.
RefSeqXP_002084627.1. XM_002084591.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0212644; FBpp0211136; FBgn0184461.
GeneID6737799.
KEGGdsi:Dsim_GD12734.

Organism-specific databases

FlyBaseFBgn0184461. Dsim\GD12734.

Phylogenomic databases

KOK01698.
OrthoDBEOG751NFP.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERPTHR11458. PTHR11458. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
SMARTSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4QR82_DROSI
AccessionPrimary (citable) accession number: B4QR82
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 11, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)