Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-aminolevulinic acid dehydratase

Gene

Dsim\GD12734

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Zinc 1; catalyticUniRule annotation
Metal bindingi120 – 1201Zinc; catalyticUniRule annotation
Metal bindingi122 – 1221Zinc 1; catalyticUniRule annotation
Metal bindingi122 – 1221Zinc; catalyticUniRule annotation
Metal bindingi129 – 1291Zinc 2UniRule annotation
Metal bindingi130 – 1301Zinc 1; catalyticUniRule annotation
Metal bindingi130 – 1301Zinc; catalyticUniRule annotation
Active sitei195 – 1951Schiff-base intermediate with substrateUniRule annotation
Binding sitei205 – 2051Substrate 1UniRule annotation
Binding sitei217 – 2171Substrate 1UniRule annotation
Metal bindingi219 – 2191Zinc 2UniRule annotation
Active sitei248 – 2481Schiff-base intermediate with substrateUniRule annotation
Binding sitei275 – 2751Substrate 2UniRule annotation
Binding sitei314 – 3141Substrate 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
Gene namesi
Name:Dsim\GD12734Imported
ORF Names:Dsim_GD12734Imported, GD12734Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0184461. Dsim\GD12734.

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

KOiK01698.
OrthoDBiEOG751NFP.
PhylomeDBiB4QR82.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4QR82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKLHSGMH HATLRQLQES GCEIAPHNLM YPVFIVSNDD DVQPIASMPG
60 70 80 90 100
ISRFGLNRLK EHLEPLVAKG LSSVLLFGVV EPDMKDEQAS NADSAKNPVV
110 120 130 140 150
LALPKLREWF PDLLIACDVC ICPYSSHGHC GLLGETGLEN GPSIKRIAEI
160 170 180 190 200
AVAYAKAGAH IVAPSDMMDN RVKAIKQALI DAQMNSVSLL AYSAKFTSNF
210 220 230 240 250
YGPFREAAQS APKFGDRRCY QLPSGSRSLA MRAIQRDVAE GADMLMVKPG
260 270 280 290 300
MPYLDILRST KDSYPYHTLY VYQVSGEFAM LYHAAKAGAF DLKDAVLEAM
310 320
KGFRRAGADC IITYYTPFLL DIIGKVK
Length:327
Mass (Da):35,948
Last modified:September 23, 2008 - v1
Checksum:i3DE1871E5F5EF3ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX10212.1.
RefSeqiXP_002084627.1. XM_002084591.1.

Genome annotation databases

EnsemblMetazoaiFBtr0212644; FBpp0211136; FBgn0184461.
GeneIDi6737799.
KEGGidsi:Dsim_GD12734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX10212.1.
RefSeqiXP_002084627.1. XM_002084591.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0212644; FBpp0211136; FBgn0184461.
GeneIDi6737799.
KEGGidsi:Dsim_GD12734.

Organism-specific databases

FlyBaseiFBgn0184461. Dsim\GD12734.

Phylogenomic databases

KOiK01698.
OrthoDBiEOG751NFP.
PhylomeDBiB4QR82.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MixedImported.

Entry informationi

Entry nameiB4QR82_DROSI
AccessioniPrimary (citable) accession number: B4QR82
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 29, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.