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Protein

Delta-aminolevulinic acid dehydratase

Gene

Dsim\GD12734

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120Zinc 1; catalyticUniRule annotation1
Metal bindingi122Zinc 1; catalyticUniRule annotation1
Metal bindingi129Zinc 2UniRule annotation1
Metal bindingi130Zinc 1; catalyticUniRule annotation1
Active sitei195Schiff-base intermediate with substrateUniRule annotation1
Binding sitei205Substrate 1UniRule annotation1
Binding sitei217Substrate 1UniRule annotation1
Metal bindingi219Zinc 2UniRule annotation1
Active sitei248Schiff-base intermediate with substrateUniRule annotation1
Binding sitei275Substrate 2UniRule annotation1
Binding sitei314Substrate 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPorphyrin biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
Gene namesi
Name:Dsim\GD12734Imported
ORF Names:Dsim_GD12734Imported, Dsimw501_GD12734Imported, GD12734Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0184461 Dsim\GD12734

Expressioni

Gene expression databases

BgeeiFBgn0184461

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

KOiK01698
OMAiYQMDYAN
OrthoDBiEOG091G0FMX

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR001731 ALAD
IPR030656 ALAD_AS
IPR013785 Aldolase_TIM
PANTHERiPTHR11458 PTHR11458, 1 hit
PfamiView protein in Pfam
PF00490 ALAD, 1 hit
PIRSFiPIRSF001415 Porphbilin_synth, 1 hit
PRINTSiPR00144 DALDHYDRTASE
SMARTiView protein in SMART
SM01004 ALAD, 1 hit
PROSITEiView protein in PROSITE
PS00169 D_ALA_DEHYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

B4QR82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKLHSGMH HATLRQLQES GCEIAPHNLM YPVFIVSNDD DVQPIASMPG
60 70 80 90 100
ISRFGLNRLK EHLEPLVAKG LSSVLLFGVV EPDMKDEQAS NADSAKNPVV
110 120 130 140 150
LALPKLREWF PDLLIACDVC ICPYSSHGHC GLLGETGLEN GPSIKRIAEI
160 170 180 190 200
AVAYAKAGAH IVAPSDMMDN RVKAIKQALI DAQMNSVSLL AYSAKFTSNF
210 220 230 240 250
YGPFREAAQS APKFGDRRCY QLPSGSRSLA MRAIQRDVAE GADMLMVKPG
260 270 280 290 300
MPYLDILRST KDSYPYHTLY VYQVSGEFAM LYHAAKAGAF DLKDAVLEAM
310 320
KGFRRAGADC IITYYTPFLL DIIGKVK
Length:327
Mass (Da):35,948
Last modified:September 23, 2008 - v1
Checksum:i3DE1871E5F5EF3ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA Translation: EDX10212.1
CM002912 Genomic DNA Translation: KMY99204.1
RefSeqiXP_002084627.1, XM_002084591.2

Genome annotation databases

EnsemblMetazoaiFBtr0212644; FBpp0211136; FBgn0184461
GeneIDi6737799
KEGGidsi:Dsimw501_GD12734

Similar proteinsi

Entry informationi

Entry nameiB4QR82_DROSI
AccessioniPrimary (citable) accession number: B4QR82
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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