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Protein

Delta-aminolevulinic acid dehydratase

Gene

Dsim\GD12734

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120Zinc 1; catalyticUniRule annotation1
Metal bindingi120Zinc; catalyticUniRule annotation1
Metal bindingi122Zinc 1; catalyticUniRule annotation1
Metal bindingi122Zinc; catalyticUniRule annotation1
Metal bindingi129Zinc 2UniRule annotation1
Metal bindingi130Zinc 1; catalyticUniRule annotation1
Metal bindingi130Zinc; catalyticUniRule annotation1
Active sitei195Schiff-base intermediate with substrateUniRule annotation1
Binding sitei205Substrate 1UniRule annotation1
Binding sitei217Substrate 1UniRule annotation1
Metal bindingi219Zinc 2UniRule annotation1
Active sitei248Schiff-base intermediate with substrateUniRule annotation1
Binding sitei275Substrate 2UniRule annotation1
Binding sitei314Substrate 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
Gene namesi
Name:Dsim\GD12734Imported
ORF Names:Dsim_GD12734Imported, Dsimw501_GD12734Imported, GD12734Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0184461. Dsim\GD12734.

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

KOiK01698.
OMAiMHHATLR.
OrthoDBiEOG091G0FMX.
PhylomeDBiB4QR82.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4QR82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKLHSGMH HATLRQLQES GCEIAPHNLM YPVFIVSNDD DVQPIASMPG
60 70 80 90 100
ISRFGLNRLK EHLEPLVAKG LSSVLLFGVV EPDMKDEQAS NADSAKNPVV
110 120 130 140 150
LALPKLREWF PDLLIACDVC ICPYSSHGHC GLLGETGLEN GPSIKRIAEI
160 170 180 190 200
AVAYAKAGAH IVAPSDMMDN RVKAIKQALI DAQMNSVSLL AYSAKFTSNF
210 220 230 240 250
YGPFREAAQS APKFGDRRCY QLPSGSRSLA MRAIQRDVAE GADMLMVKPG
260 270 280 290 300
MPYLDILRST KDSYPYHTLY VYQVSGEFAM LYHAAKAGAF DLKDAVLEAM
310 320
KGFRRAGADC IITYYTPFLL DIIGKVK
Length:327
Mass (Da):35,948
Last modified:September 23, 2008 - v1
Checksum:i3DE1871E5F5EF3ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX10212.1.
CM002912 Genomic DNA. Translation: KMY99204.1.
RefSeqiXP_002084627.1. XM_002084591.2.

Genome annotation databases

EnsemblMetazoaiFBtr0212644; FBpp0211136; FBgn0184461.
GeneIDi6737799.
KEGGidsi:Dsimw501_GD12734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX10212.1.
CM002912 Genomic DNA. Translation: KMY99204.1.
RefSeqiXP_002084627.1. XM_002084591.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0212644; FBpp0211136; FBgn0184461.
GeneIDi6737799.
KEGGidsi:Dsimw501_GD12734.

Organism-specific databases

FlyBaseiFBgn0184461. Dsim\GD12734.

Phylogenomic databases

KOiK01698.
OMAiMHHATLR.
OrthoDBiEOG091G0FMX.
PhylomeDBiB4QR82.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4QR82_DROSI
AccessioniPrimary (citable) accession number: B4QR82
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.