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B4QR82

- B4QR82_DROSI

UniProt

B4QR82 - B4QR82_DROSI

Protein

Delta-aminolevulinic acid dehydratase

Gene

Dsim\GD12734

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Zinc 1; catalyticUniRule annotation
    Metal bindingi122 – 1221Zinc 1; catalyticUniRule annotation
    Metal bindingi129 – 1291Zinc 2UniRule annotation
    Metal bindingi130 – 1301Zinc 1; catalyticUniRule annotation
    Active sitei195 – 1951Schiff-base intermediate with substrateUniRule annotation
    Binding sitei205 – 2051Substrate 1UniRule annotation
    Binding sitei217 – 2171Substrate 1UniRule annotation
    Metal bindingi219 – 2191Zinc 2UniRule annotation
    Active sitei248 – 2481Schiff-base intermediate with substrateUniRule annotation
    Binding sitei275 – 2751Substrate 2UniRule annotation
    Binding sitei314 – 3141Substrate 2UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: InterPro
    2. porphobilinogen synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
    Gene namesi
    Name:Dsim\GD12734Imported
    ORF Names:Dsim_GD12734Imported, GD12734Imported
    OrganismiDrosophila simulans (Fruit fly)Imported
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000304: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0184461. Dsim\GD12734.

    Interactioni

    Subunit structurei

    Homooctamer.UniRule annotation
    Homooctamer By similarity.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.UniRule annotation

    Phylogenomic databases

    KOiK01698.
    OrthoDBiEOG751NFP.
    PhylomeDBiB4QR82.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4QR82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERKLHSGMH HATLRQLQES GCEIAPHNLM YPVFIVSNDD DVQPIASMPG    50
    ISRFGLNRLK EHLEPLVAKG LSSVLLFGVV EPDMKDEQAS NADSAKNPVV 100
    LALPKLREWF PDLLIACDVC ICPYSSHGHC GLLGETGLEN GPSIKRIAEI 150
    AVAYAKAGAH IVAPSDMMDN RVKAIKQALI DAQMNSVSLL AYSAKFTSNF 200
    YGPFREAAQS APKFGDRRCY QLPSGSRSLA MRAIQRDVAE GADMLMVKPG 250
    MPYLDILRST KDSYPYHTLY VYQVSGEFAM LYHAAKAGAF DLKDAVLEAM 300
    KGFRRAGADC IITYYTPFLL DIIGKVK 327
    Length:327
    Mass (Da):35,948
    Last modified:September 23, 2008 - v1
    Checksum:i3DE1871E5F5EF3ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000363 Genomic DNA. Translation: EDX10212.1.
    RefSeqiXP_002084627.1. XM_002084591.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0212644; FBpp0211136; FBgn0184461.
    GeneIDi6737799.
    KEGGidsi:Dsim_GD12734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000363 Genomic DNA. Translation: EDX10212.1 .
    RefSeqi XP_002084627.1. XM_002084591.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0212644 ; FBpp0211136 ; FBgn0184461 .
    GeneIDi 6737799.
    KEGGi dsi:Dsim_GD12734.

    Organism-specific databases

    FlyBasei FBgn0184461. Dsim\GD12734.

    Phylogenomic databases

    KOi K01698.
    OrthoDBi EOG751NFP.
    PhylomeDBi B4QR82.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MixedImported.

    Entry informationi

    Entry nameiB4QR82_DROSI
    AccessioniPrimary (citable) accession number: B4QR82
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3