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Protein

Aldose 1-epimerase

Gene

Dsim\GD14983

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts alpha-aldose to the beta-anomer.UniRule annotation

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. aldose 1-epimerase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimeraseUniRule annotation (EC:5.1.3.3UniRule annotation)
Alternative name(s):
Galactose mutarotaseUniRule annotation
Gene namesi
Name:Dsim\GD14983Imported
ORF Names:Dsim_GD14983Imported, GD14983Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0186655. Dsim\GD14983.

Structurei

3D structure databases

ProteinModelPortaliB4QK81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldose epimerase family.UniRule annotation

Phylogenomic databases

KOiK01785.
OrthoDBiEOG7V7666.
PhylomeDBiB4QK81.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

B4QK81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVIEDMFG IAVNPMTQKT DRVRRFTLIT ERGMSVSILT MGAIIQSLKV
60 70 80 90 100
PDFNGKLEDV CLGYDDVAGY YRNQQYFFGA TIGRMANRTA HGRFKLCGKE
110 120 130 140 150
VSVSRNLRDR HHQNGGFVGF DSVIWDVVGV HKDGVTLQHI SPDGHEGYPG
160 170 180 190 200
ELTTNINFSL NETGCFGMRI EARTKATTAV NISNHSFFNL AGHGAGRDSL
210 220 230 240 250
YQHMLMIKAQ KIVDVDQELL PTGKLMRVRT TPYDFSSLVS LGKRLNQVST
260 270 280 290 300
CPLGGFDNHF CVDIPPNRVQ LVARVVHPCS GRFMEVHTNQ PGLQFSTANH
310 320 330 340 350
LPSEDSSDIP ISGKDGSNYV RQGAFTLQTQ KYPDAMNHCD FPSVVLNPGQ
360
LYDHQVVYRF GSCPKRV
Length:367
Mass (Da):40,876
Last modified:September 23, 2008 - v1
Checksum:i08C73D9935476E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX11418.1.
RefSeqiXP_002085833.1. XM_002085797.1.
UniGeneiDsi.391.

Genome annotation databases

EnsemblMetazoaiFBtr0214893; FBpp0213385; FBgn0186655.
GeneIDi6739038.
KEGGidsi:Dsim_GD14983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX11418.1.
RefSeqiXP_002085833.1. XM_002085797.1.
UniGeneiDsi.391.

3D structure databases

ProteinModelPortaliB4QK81.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0214893; FBpp0213385; FBgn0186655.
GeneIDi6739038.
KEGGidsi:Dsim_GD14983.

Organism-specific databases

FlyBaseiFBgn0186655. Dsim\GD14983.

Phylogenomic databases

KOiK01785.
OrthoDBiEOG7V7666.
PhylomeDBiB4QK81.

Enzyme and pathway databases

UniPathwayiUPA00242.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MixedImported.

Entry informationi

Entry nameiB4QK81_DROSI
AccessioniPrimary (citable) accession number: B4QK81
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.