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B4QIS3 (UBP36_DROSI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GD13899
OrganismDrosophila simulans (Fruit fly) [Complete proteome]
Taxonomic identifier7240 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length988 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 988988Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378502

Regions

Domain78 – 386309USP

Sites

Active site871Nucleophile By similarity
Active site3451Proton acceptor By similarity

Amino acid modifications

Modified residue4191Phosphoserine By similarity
Modified residue4211Phosphoserine By similarity
Modified residue5611Phosphothreonine By similarity
Modified residue5651Phosphothreonine By similarity
Modified residue5751Phosphoserine By similarity
Modified residue5771Phosphoserine By similarity
Modified residue6501Phosphoserine By similarity
Modified residue6821Phosphoserine By similarity
Modified residue6851Phosphothreonine By similarity
Modified residue6881Phosphoserine By similarity
Modified residue7281Phosphothreonine By similarity
Modified residue7461Phosphoserine By similarity
Modified residue7491Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4QIS3 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 2E0027E8315CE4CB

FASTA988108,676
        10         20         30         40         50         60 
MLHSLVPRYN KCVPFPTLRT DNNGARKQAE HPNNQSHHNH PHPTSNPNEL PKPKRVLYPR 

        70         80         90        100        110        120 
ENIRIGWKQS ERKWQVGTGM INVGNTCYLN STLQALLHIP ALANWLVSEQ AHLADCNVAE 

       130        140        150        160        170        180 
PGSGCIICAM AKTLLATQSN QSAVRPFLIY SKLKQICKHM VVGRQEDAHE FLRFLVEAME 

       190        200        210        220        230        240 
RAYLMRFRNY KELDQLVKET TPLGQIFGGY LRSEVRCLSC NHVSITFQHF QDLLLDIRKA 

       250        260        270        280        290        300 
DSLEDAFEGH FSRERLEDMG YKCEGCKKKV SATKQFSLER APITLCIQLK RFSMIGNKLT 

       310        320        330        340        350        360 
KQISFKPRID LSKYAARSPA AQAQPLTYRL VSMVTHLGAS QHCGHYTAIG STDTGSFYNF 

       370        380        390        400        410        420 
DDSYVRPITM QNVCNTNAYI MFFELDLSQA ASPPANRPNG VRLTNGHSTT PVPAATVSSP 

       430        440        450        460        470        480 
SPTRFIGPQL PPVGANGYTN GNAQKTAIQF KQQNQQNGLQ LGTGKFQDTA KPPLVGAYAK 

       490        500        510        520        530        540 
GEATSAPTAN GNKSSSPSSN SSSNHKSINQ QQYLPISSDD EDIDDEMKPG PTTAQLPSMP 

       550        560        570        580        590        600 
NMTEDSTEPK AKSPVKIHLK TPVKTPLKSL VPYESASEEE EAPLPNPRQS TEGEDFSESD 

       610        620        630        640        650        660 
QESGQTNGHS KTNGSLTNGS ASSSVHVNNS KQKTDAIDEI FKSLKKSADS EEDDDEEEPS 

       670        680        690        700        710        720 
IQLTNGWHPQ KQSQSQSKAP PSPKTPPSPA VIKSKTGIWK VTRNDEVDAI DDDDDAVVVE 

       730        740        750        760        770        780 
GAPVKIPTPN KTHRNPFSSS KPSTDSPATP GAKRQKLLNG SALKSHQQPR VGNGYQSNVT 

       790        800        810        820        830        840 
SNGSTVNELL KQSYRGYGAS VLSWNGKPAE LEKEPFELVC AKRIAGHGSV EGSDIVEGSV 

       850        860        870        880        890        900 
AVDAAVTSSS DSNDVVVIAV ALLVDAREQR QRDLDDDEEN EMDRGRQRKV KSGSAKGNNA 

       910        920        930        940        950        960 
SNSTPGYNPF QEYEGQKRWN KNGGGGGFSR FHNQNYRQNF QQRNKFKFNR FGGQGSAKFQ 

       970        980 
QQRALQRHLS AGGGFSRRQP SAQQQQQT 

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000363 Genomic DNA. Translation: EDX09348.1.
RefSeqXP_002083763.1. XM_002083727.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0213809; FBpp0212301; FBgn0185595.
GeneID6736916.
KEGGdsi:Dsim_GD13899.

Organism-specific databases

FlyBaseFBgn0185595. Dsim\GD13899.

Phylogenomic databases

KOK11855.
OrthoDBEOG7XDBF6.
PhylomeDBB4QIS3.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROSI
AccessionPrimary (citable) accession number: B4QIS3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase