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B4QIS3

- UBP36_DROSI

UniProt

B4QIS3 - UBP36_DROSI

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871NucleophilePROSITE-ProRule annotation
    Active sitei345 – 3451Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GD13899
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000304: Chromosome 3L, UP000000304: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0185595. Dsim\GD13899.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 988988Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378502Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei419 – 4191PhosphoserineBy similarity
    Modified residuei421 – 4211PhosphoserineBy similarity
    Modified residuei561 – 5611PhosphothreonineBy similarity
    Modified residuei565 – 5651PhosphothreonineBy similarity
    Modified residuei575 – 5751PhosphoserineBy similarity
    Modified residuei577 – 5771PhosphoserineBy similarity
    Modified residuei650 – 6501PhosphoserineBy similarity
    Modified residuei682 – 6821PhosphoserineBy similarity
    Modified residuei685 – 6851PhosphothreonineBy similarity
    Modified residuei688 – 6881PhosphoserineBy similarity
    Modified residuei728 – 7281PhosphothreonineBy similarity
    Modified residuei746 – 7461PhosphoserineBy similarity
    Modified residuei749 – 7491PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini78 – 386309USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    KOiK11855.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB4QIS3.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4QIS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHSLVPRYN KCVPFPTLRT DNNGARKQAE HPNNQSHHNH PHPTSNPNEL    50
    PKPKRVLYPR ENIRIGWKQS ERKWQVGTGM INVGNTCYLN STLQALLHIP 100
    ALANWLVSEQ AHLADCNVAE PGSGCIICAM AKTLLATQSN QSAVRPFLIY 150
    SKLKQICKHM VVGRQEDAHE FLRFLVEAME RAYLMRFRNY KELDQLVKET 200
    TPLGQIFGGY LRSEVRCLSC NHVSITFQHF QDLLLDIRKA DSLEDAFEGH 250
    FSRERLEDMG YKCEGCKKKV SATKQFSLER APITLCIQLK RFSMIGNKLT 300
    KQISFKPRID LSKYAARSPA AQAQPLTYRL VSMVTHLGAS QHCGHYTAIG 350
    STDTGSFYNF DDSYVRPITM QNVCNTNAYI MFFELDLSQA ASPPANRPNG 400
    VRLTNGHSTT PVPAATVSSP SPTRFIGPQL PPVGANGYTN GNAQKTAIQF 450
    KQQNQQNGLQ LGTGKFQDTA KPPLVGAYAK GEATSAPTAN GNKSSSPSSN 500
    SSSNHKSINQ QQYLPISSDD EDIDDEMKPG PTTAQLPSMP NMTEDSTEPK 550
    AKSPVKIHLK TPVKTPLKSL VPYESASEEE EAPLPNPRQS TEGEDFSESD 600
    QESGQTNGHS KTNGSLTNGS ASSSVHVNNS KQKTDAIDEI FKSLKKSADS 650
    EEDDDEEEPS IQLTNGWHPQ KQSQSQSKAP PSPKTPPSPA VIKSKTGIWK 700
    VTRNDEVDAI DDDDDAVVVE GAPVKIPTPN KTHRNPFSSS KPSTDSPATP 750
    GAKRQKLLNG SALKSHQQPR VGNGYQSNVT SNGSTVNELL KQSYRGYGAS 800
    VLSWNGKPAE LEKEPFELVC AKRIAGHGSV EGSDIVEGSV AVDAAVTSSS 850
    DSNDVVVIAV ALLVDAREQR QRDLDDDEEN EMDRGRQRKV KSGSAKGNNA 900
    SNSTPGYNPF QEYEGQKRWN KNGGGGGFSR FHNQNYRQNF QQRNKFKFNR 950
    FGGQGSAKFQ QQRALQRHLS AGGGFSRRQP SAQQQQQT 988
    Length:988
    Mass (Da):108,676
    Last modified:September 23, 2008 - v1
    Checksum:i2E0027E8315CE4CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000363 Genomic DNA. Translation: EDX09348.1.
    RefSeqiXP_002083763.1. XM_002083727.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0213809; FBpp0212301; FBgn0185595.
    GeneIDi6736916.
    KEGGidsi:Dsim_GD13899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000363 Genomic DNA. Translation: EDX09348.1 .
    RefSeqi XP_002083763.1. XM_002083727.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0213809 ; FBpp0212301 ; FBgn0185595 .
    GeneIDi 6736916.
    KEGGi dsi:Dsim_GD13899.

    Organism-specific databases

    FlyBasei FBgn0185595. Dsim\GD13899.

    Phylogenomic databases

    KOi K11855.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B4QIS3.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUBP36_DROSI
    AccessioniPrimary (citable) accession number: B4QIS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3