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B4QIS3

- UBP36_DROSI

UniProt

B4QIS3 - UBP36_DROSI

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Protein
Ubiquitin carboxyl-terminal hydrolase 36
Gene
Usp36, scny, GD13899
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Nucleophile By similarity
Active sitei345 – 3451Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GD13899
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 3L, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0185595. Dsim\GD13899.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 988988Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei419 – 4191Phosphoserine By similarity
Modified residuei421 – 4211Phosphoserine By similarity
Modified residuei561 – 5611Phosphothreonine By similarity
Modified residuei565 – 5651Phosphothreonine By similarity
Modified residuei575 – 5751Phosphoserine By similarity
Modified residuei577 – 5771Phosphoserine By similarity
Modified residuei650 – 6501Phosphoserine By similarity
Modified residuei682 – 6821Phosphoserine By similarity
Modified residuei685 – 6851Phosphothreonine By similarity
Modified residuei688 – 6881Phosphoserine By similarity
Modified residuei728 – 7281Phosphothreonine By similarity
Modified residuei746 – 7461Phosphoserine By similarity
Modified residuei749 – 7491Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 386309USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4QIS3.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4QIS3-1 [UniParc]FASTAAdd to Basket

« Hide

MLHSLVPRYN KCVPFPTLRT DNNGARKQAE HPNNQSHHNH PHPTSNPNEL    50
PKPKRVLYPR ENIRIGWKQS ERKWQVGTGM INVGNTCYLN STLQALLHIP 100
ALANWLVSEQ AHLADCNVAE PGSGCIICAM AKTLLATQSN QSAVRPFLIY 150
SKLKQICKHM VVGRQEDAHE FLRFLVEAME RAYLMRFRNY KELDQLVKET 200
TPLGQIFGGY LRSEVRCLSC NHVSITFQHF QDLLLDIRKA DSLEDAFEGH 250
FSRERLEDMG YKCEGCKKKV SATKQFSLER APITLCIQLK RFSMIGNKLT 300
KQISFKPRID LSKYAARSPA AQAQPLTYRL VSMVTHLGAS QHCGHYTAIG 350
STDTGSFYNF DDSYVRPITM QNVCNTNAYI MFFELDLSQA ASPPANRPNG 400
VRLTNGHSTT PVPAATVSSP SPTRFIGPQL PPVGANGYTN GNAQKTAIQF 450
KQQNQQNGLQ LGTGKFQDTA KPPLVGAYAK GEATSAPTAN GNKSSSPSSN 500
SSSNHKSINQ QQYLPISSDD EDIDDEMKPG PTTAQLPSMP NMTEDSTEPK 550
AKSPVKIHLK TPVKTPLKSL VPYESASEEE EAPLPNPRQS TEGEDFSESD 600
QESGQTNGHS KTNGSLTNGS ASSSVHVNNS KQKTDAIDEI FKSLKKSADS 650
EEDDDEEEPS IQLTNGWHPQ KQSQSQSKAP PSPKTPPSPA VIKSKTGIWK 700
VTRNDEVDAI DDDDDAVVVE GAPVKIPTPN KTHRNPFSSS KPSTDSPATP 750
GAKRQKLLNG SALKSHQQPR VGNGYQSNVT SNGSTVNELL KQSYRGYGAS 800
VLSWNGKPAE LEKEPFELVC AKRIAGHGSV EGSDIVEGSV AVDAAVTSSS 850
DSNDVVVIAV ALLVDAREQR QRDLDDDEEN EMDRGRQRKV KSGSAKGNNA 900
SNSTPGYNPF QEYEGQKRWN KNGGGGGFSR FHNQNYRQNF QQRNKFKFNR 950
FGGQGSAKFQ QQRALQRHLS AGGGFSRRQP SAQQQQQT 988
Length:988
Mass (Da):108,676
Last modified:September 23, 2008 - v1
Checksum:i2E0027E8315CE4CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000363 Genomic DNA. Translation: EDX09348.1.
RefSeqiXP_002083763.1. XM_002083727.1.

Genome annotation databases

EnsemblMetazoaiFBtr0213809; FBpp0212301; FBgn0185595.
GeneIDi6736916.
KEGGidsi:Dsim_GD13899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000363 Genomic DNA. Translation: EDX09348.1 .
RefSeqi XP_002083763.1. XM_002083727.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0213809 ; FBpp0212301 ; FBgn0185595 .
GeneIDi 6736916.
KEGGi dsi:Dsim_GD13899.

Organism-specific databases

FlyBasei FBgn0185595. Dsim\GD13899.

Phylogenomic databases

KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4QIS3.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP36_DROSI
AccessioniPrimary (citable) accession number: B4QIS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi