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B4QIS3

- UBP36_DROSI

UniProt

B4QIS3 - UBP36_DROSI

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871NucleophilePROSITE-ProRule annotation
Active sitei345 – 3451Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GD13899
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 3L, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0185595. Dsim\GD13899.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 988988Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei419 – 4191PhosphoserineBy similarity
Modified residuei421 – 4211PhosphoserineBy similarity
Modified residuei561 – 5611PhosphothreonineBy similarity
Modified residuei565 – 5651PhosphothreonineBy similarity
Modified residuei575 – 5751PhosphoserineBy similarity
Modified residuei577 – 5771PhosphoserineBy similarity
Modified residuei650 – 6501PhosphoserineBy similarity
Modified residuei682 – 6821PhosphoserineBy similarity
Modified residuei685 – 6851PhosphothreonineBy similarity
Modified residuei688 – 6881PhosphoserineBy similarity
Modified residuei728 – 7281PhosphothreonineBy similarity
Modified residuei746 – 7461PhosphoserineBy similarity
Modified residuei749 – 7491PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 386309USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4QIS3.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4QIS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHSLVPRYN KCVPFPTLRT DNNGARKQAE HPNNQSHHNH PHPTSNPNEL
60 70 80 90 100
PKPKRVLYPR ENIRIGWKQS ERKWQVGTGM INVGNTCYLN STLQALLHIP
110 120 130 140 150
ALANWLVSEQ AHLADCNVAE PGSGCIICAM AKTLLATQSN QSAVRPFLIY
160 170 180 190 200
SKLKQICKHM VVGRQEDAHE FLRFLVEAME RAYLMRFRNY KELDQLVKET
210 220 230 240 250
TPLGQIFGGY LRSEVRCLSC NHVSITFQHF QDLLLDIRKA DSLEDAFEGH
260 270 280 290 300
FSRERLEDMG YKCEGCKKKV SATKQFSLER APITLCIQLK RFSMIGNKLT
310 320 330 340 350
KQISFKPRID LSKYAARSPA AQAQPLTYRL VSMVTHLGAS QHCGHYTAIG
360 370 380 390 400
STDTGSFYNF DDSYVRPITM QNVCNTNAYI MFFELDLSQA ASPPANRPNG
410 420 430 440 450
VRLTNGHSTT PVPAATVSSP SPTRFIGPQL PPVGANGYTN GNAQKTAIQF
460 470 480 490 500
KQQNQQNGLQ LGTGKFQDTA KPPLVGAYAK GEATSAPTAN GNKSSSPSSN
510 520 530 540 550
SSSNHKSINQ QQYLPISSDD EDIDDEMKPG PTTAQLPSMP NMTEDSTEPK
560 570 580 590 600
AKSPVKIHLK TPVKTPLKSL VPYESASEEE EAPLPNPRQS TEGEDFSESD
610 620 630 640 650
QESGQTNGHS KTNGSLTNGS ASSSVHVNNS KQKTDAIDEI FKSLKKSADS
660 670 680 690 700
EEDDDEEEPS IQLTNGWHPQ KQSQSQSKAP PSPKTPPSPA VIKSKTGIWK
710 720 730 740 750
VTRNDEVDAI DDDDDAVVVE GAPVKIPTPN KTHRNPFSSS KPSTDSPATP
760 770 780 790 800
GAKRQKLLNG SALKSHQQPR VGNGYQSNVT SNGSTVNELL KQSYRGYGAS
810 820 830 840 850
VLSWNGKPAE LEKEPFELVC AKRIAGHGSV EGSDIVEGSV AVDAAVTSSS
860 870 880 890 900
DSNDVVVIAV ALLVDAREQR QRDLDDDEEN EMDRGRQRKV KSGSAKGNNA
910 920 930 940 950
SNSTPGYNPF QEYEGQKRWN KNGGGGGFSR FHNQNYRQNF QQRNKFKFNR
960 970 980
FGGQGSAKFQ QQRALQRHLS AGGGFSRRQP SAQQQQQT
Length:988
Mass (Da):108,676
Last modified:September 23, 2008 - v1
Checksum:i2E0027E8315CE4CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX09348.1.
RefSeqiXP_002083763.1. XM_002083727.1.

Genome annotation databases

EnsemblMetazoaiFBtr0213809; FBpp0212301; FBgn0185595.
GeneIDi6736916.
KEGGidsi:Dsim_GD13899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000363 Genomic DNA. Translation: EDX09348.1 .
RefSeqi XP_002083763.1. XM_002083727.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0213809 ; FBpp0212301 ; FBgn0185595 .
GeneIDi 6736916.
KEGGi dsi:Dsim_GD13899.

Organism-specific databases

FlyBasei FBgn0185595. Dsim\GD13899.

Phylogenomic databases

KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4QIS3.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP36_DROSI
AccessioniPrimary (citable) accession number: B4QIS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3