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B4QHH0

- CALYP_DROSI

UniProt

B4QHH0 - CALYP_DROSI

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Protein
Ubiquitin carboxyl-terminal hydrolase calypso
Gene
calypso, GD25561
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Nucleophile By similarity
Active sitei213 – 2131Proton donor By similarity
Sitei228 – 2281Important for enzyme activity By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB
  3. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:GD25561
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 2R, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0196847. Dsim\GD25561.

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs) By similarity.

GO - Cellular componenti

  1. PR-DUB complex Source: UniProtKB
  2. nuclear chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Ubiquitin carboxyl-terminal hydrolase calypso
PRO_0000395833Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx By similarity.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK08588.
OrthoDBiEOG7GN2M2.
PhylomeDBiB4QHH0.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B4QHH0-1 [UniParc]FASTAAdd to Basket

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MNAAGGGSGA QAAGVAAGNS SLSHNALLST ASGATTMPMA QLADGWLELE    50
SDPGLFTLLL KDFGCHDVQV EEVYDLQKPI ESPYGFIFLF RWIEERRARR 100
KIVETTAEIF VKDEEAISSI FFAQQVVPNS CATHALLSVL LNCNENNLQL 150
GDTLSRLKTH TKGMSPENKG LAIGNTPELA CAHNSHAMPQ ARRRLERTGA 200
GVSSCRFTGE AFHFVSFVPI NGQLFELDGL KPYPMNHGGW EDSEDWTDKF 250
RRVMAERLGI ATGEQDIRFN LMAVVPDRRI AITHKLKMLR TNQAIVSGTL 300
QKLLKADEQG ESGNGDSQRP DTPTTLLEPS AFTARDLQSL LKNLDTEIAI 350
NEQHLADEND RRHMFKVDAS RRTHNYDKFI CTFLSMLAHQ GVLGELVSQH 400
LLPSKKVSGQ GAANRISKQS NTASAGGSTT GASASTPKTQ QQQAATAKNG 450
KSPSKTPGRR RKGRNKCRKR K 471
Length:471
Mass (Da):51,525
Last modified:September 23, 2008 - v1
Checksum:i567840D5C8621324
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000362 Genomic DNA. Translation: EDX07315.1.
RefSeqiXP_002081730.1. XM_002081694.1.

Genome annotation databases

EnsemblMetazoaiFBtr0225471; FBpp0223963; FBgn0196847.
GeneIDi6734723.
KEGGidsi:Dsim_GD25561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000362 Genomic DNA. Translation: EDX07315.1 .
RefSeqi XP_002081730.1. XM_002081694.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C12.A09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0225471 ; FBpp0223963 ; FBgn0196847 .
GeneIDi 6734723.
KEGGi dsi:Dsim_GD25561.

Organism-specific databases

FlyBasei FBgn0196847. Dsim\GD25561.

Phylogenomic databases

KOi K08588.
OrthoDBi EOG7GN2M2.
PhylomeDBi B4QHH0.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCALYP_DROSI
AccessioniPrimary (citable) accession number: B4QHH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi