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Protein

DNA ligase

Gene

Dsim\GD11806

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dsim\GD11806Imported
ORF Names:Dsim_GD11806Imported, GD11806Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0183545. Dsim\GD11806.

Structurei

3D structure databases

ProteinModelPortaliB4QB17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7RFTGN.
PhylomeDBiB4QB17.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4QB17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKSITSFFK KKSDATDSPS PPKKVPKIDA KTELPDEPHI KSESASPETK
60 70 80 90 100
PKVEPMSVDS EEKTSPVKNV KKEPKDTVDK TTDKKVTTIG LNSTSASKED
110 120 130 140 150
AENYDPSADS YHPLKNAYWK DKKVTPYLAL ARTFQVIEET KGRLKMIDTL
160 170 180 190 200
SNFFCSVMLV SPEDLVPSVY LSINQLAPAY EGMELGVAET TLMKAICKAT
210 220 230 240 250
GRNLAHIKSQ THLIGDLGIV AEQSRVSQRM MFQPAPLNVR DVFRKLREIA
260 270 280 290 300
KISGQSKMDM VYNMFVACRL SEARFFIRSL IGKLRIGMQS RVCSQRWPLG
310 320 330 340 350
CQCPNYDIII PAILKYDIKE LQERCPMHPG MPLRPMLAQP TKGVHEVFER
360 370 380 390 400
FGGMQITCEW KYDGERAQIH RNEKGEISIF SRNSENNTAK YPDLIARSTG
410 420 430 440 450
LLKGDVKSYI IDSEIVAWDV ERKQILPFQV LSTRKRKNVD IEEIKVQVCV
460 470 480 490 500
YIFDLLYING TALVTKNLSE RRKLLLEHFQ EVEGEWKFAT ALDTNDIDEV
510 520 530 540 550
QQFLEESIKG NCEGLMVKTL DEEATYEIAK RSRNWLKLKK DYLSNVGDSL
560 570 580 590 600
DLVVIGGYKG KGRRTGTYGG FLLACYDTEN EEYQSICKIG TGFTDEDLQT
610 620 630 640 650
HSEFLGKHVT SAAKSYYRYD PSLEPDHWFE PVQVWEVKCA DLSLSPIHRA
660 670 680 690 700
AIGIVDGERG ISLRFPRFIR IRDDKNSENA TDANQVAHMY QSQDQVKNNQ
710
KSSTQMEMED EFY
Length:713
Mass (Da):81,123
Last modified:September 23, 2008 - v1
Checksum:i3EAA7852A2B47DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000362 Genomic DNA. Translation: EDX08454.1.
RefSeqiXP_002082869.1. XM_002082833.1.

Genome annotation databases

EnsemblMetazoaiFBtr0211716; FBpp0210208; FBgn0183545.
GeneIDi6735960.
KEGGidsi:Dsim_GD11806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000362 Genomic DNA. Translation: EDX08454.1.
RefSeqiXP_002082869.1. XM_002082833.1.

3D structure databases

ProteinModelPortaliB4QB17.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0211716; FBpp0210208; FBgn0183545.
GeneIDi6735960.
KEGGidsi:Dsim_GD11806.

Organism-specific databases

FlyBaseiFBgn0183545. Dsim\GD11806.

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7RFTGN.
PhylomeDBiB4QB17.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MixedImported.

Entry informationi

Entry nameiB4QB17_DROSI
AccessioniPrimary (citable) accession number: B4QB17
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.