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Protein

Proteasome subunit alpha type

Gene

Dsim\GD23664

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:Dsim\GD23664Imported
ORF Names:Dsim_GD23664Imported, Dsimw501_GD23664Imported, GD23664Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0195041. Dsim\GD23664.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomePROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiFBgn0195041.

Interactioni

Subunit structurei

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 28PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

KOiK02725.
OMAiFMKQQCL.
OrthoDBiEOG091G0DNK.
PhylomeDBiB4Q8Q8.

Family and domain databases

CDDicd03749. proteasome_alpha_type_1. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR035144. Proteasome_alpha1.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PANTHERiPTHR11599:SF12. PTHR11599:SF12. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B4Q8Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDSDV TVWSPQGRLH QVEYAMEAVK LGTATVGLKN KDYAVLVALC
60 70 80 90 100
KPTSELSDTQ RKIIPIDDHL GISIAGLTAD ARVLSRYLRS ECLNYKHSYD
110 120 130 140 150
STYPVSRLIT NLGNKMQTTT QRYDRRPYGV GLLVAGYDER GPHIYQVTPS
160 170 180 190 200
ATFFNCKANS IGSRSQSART YLERNLNKFL DCSKDEIIRH GIRAILGTLP
210 220 230 240 250
TDEHQGKDNA GQFDITVAIV GKDQPFKMYS VKESAKYVAL AKLNDNDTPR
260 270 280
NDDDDDRPSP PEEPTAGPRD PEVLVATEQR P
Length:281
Mass (Da):31,458
Last modified:September 23, 2008 - v1
Checksum:iC7D219EF7AF57E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000361 Genomic DNA. Translation: EDX04473.1.
CM002910 Genomic DNA. Translation: KMY89429.1.
RefSeqiXP_002078888.1. XM_002078852.2.

Genome annotation databases

EnsemblMetazoaiFBtr0223574; FBpp0222066; FBgn0195041.
GeneIDi6731753.
KEGGidsi:Dsimw501_GD23664.

Similar proteinsi

Entry informationi

Entry nameiB4Q8Q8_DROSI
AccessioniPrimary (citable) accession number: B4Q8Q8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported