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Protein

Trifunctional purine biosynthetic protein adenosine-3

Gene

Dsim\GD22518

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Trifunctional purine biosynthetic protein adenosine-3 (Dsim\GD22518)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (Dsim\GD19452), Amidophosphoribosyltransferase (CG2867), Amidophosphoribosyltransferase (Dsim\GD13106)
  2. Trifunctional purine biosynthetic protein adenosine-3 (Dsim\GD22518)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Trifunctional purine biosynthetic protein adenosine-3 (Dsim\GD22518)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported, MethyltransferaseImported, Multifunctional enzymeUniRule annotation, Transferase
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00125.
UPA00074; UER00126.
UPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Trifunctional purine biosynthetic protein adenosine-3UniRule annotation
Including the following 3 domains:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
Glycinamide ribonucleotide synthetaseUniRule annotation
Short name:
GARSUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
Short name:
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Phosphoribosylglycinamide formyltransferaseUniRule annotation (EC:2.1.2.2UniRule annotation)
Alternative name(s):
5'-phosphoribosylglycinamide transformylaseUniRule annotation
GAR transformylaseUniRule annotation
Short name:
GARTUniRule annotation
Gene namesi
Name:Dsim\GD22518Imported
ORF Names:Dsim_GD22518Imported, Dsimw501_GD22518Imported, GD22518Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0193920. Dsim\GD22518.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0193920.

Structurei

3D structure databases

ProteinModelPortaliB4Q5B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 321ATP-graspInterPro annotationAdd BLAST208

Sequence similaritiesi

In the C-terminal section; belongs to the GART family.UniRule annotation
In the N-terminal section; belongs to the GARS family.UniRule annotation
In the central section; belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

KOiK11787.
OMAiLLERHNC.
OrthoDBiEOG091G026D.
PhylomeDBiB4Q5B4.

Family and domain databases

CDDicd08645. FMT_core_GART. 1 hit.
cd02196. PurM. 2 hits.
Gene3Di3.30.1330.10. 2 hits.
3.30.1490.20. 1 hit.
3.90.600.10. 1 hit.
3.90.650.10. 2 hits.
HAMAPiMF_00741. AIRS. 1 hit.
MF_00138. GARS. 1 hit.
MF_01930. PurN. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR002376. Formyl_transf_N.
IPR036477. Formyl_transf_N_sf.
IPR004607. GART.
IPR001555. GART_AS.
IPR016185. PreATP-grasp_dom_sf.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR037123. PRibGlycinamide_synth_C_sf.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
IPR011054. Rudment_hybrid_motif.
PANTHERiPTHR10520. PTHR10520. 2 hits.
PfamiView protein in Pfam
PF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
PF00551. Formyl_trans_N. 1 hit.
PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
SMARTiView protein in SMART
SM01210. GARS_C. 1 hit.
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsiTIGR00877. purD. 1 hit.
TIGR00878. purM. 2 hits.
TIGR00639. PurN. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
PS00373. GART. 1 hit.

Sequencei

Sequence statusi: Complete.

B4Q5B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRVLVIGS GGREHAICWK LSQSPKVAQI YALPGSHGIQ LVEKCRNLDA
60 70 80 90 100
KTLDPKDFEA IAKWSKENQI ALVVVGPEDP LALGLGDVLQ SAGIPCFGPG
110 120 130 140 150
KQGAQIEADK KWAKDFMLRH GIPTARYESF TDTEKAKAFI RSAPYPALVV
160 170 180 190 200
KAAGLAAGKG VVVAANAEEA CQAVDEILGE LKYGQAGATL VVEELLEGEE
210 220 230 240 250
VSVLAFTDGK SVRAMLPAQD HKRLGNGDTG PNTGGMGAYC PCPLISQPAL
260 270 280 290 300
ELVQKAVLER AVQGLIKERI NYQGVLYAGL MLTRDGPRVL EFNCRFGDPE
310 320 330 340 350
TQVILPLLEN DLFEVMQACC SAKLDKIPLQ WRNGVSAVGV ILASAGYPET
360 370 380 390 400
STKGCIISGL PAANTPTQLV FHSGLAVNAQ KEALTNGGRV LIAIALDGSL
410 420 430 440 450
KEAAAKATKL AGSITFSGSG AQYRTDIAQK AFKIASASAP GLSYKDSGVD
460 470 480 490 500
IDAGDALVQR IKPLSRGTQR PGVLGGLGGF GGLFRLKELS YKEPVIAEAT
510 520 530 540 550
QGVGAKIHLA LEHELYENVG YDLFALAAND VLEVGAEPVA FLDYIACGKL
560 570 580 590 600
QVPLAAQLVK GMADGCRDAR CALVGGETAE MPSLYAPGQH DMAGYCVGIV
610 620 630 640 650
EQSRILPRFD LYQPGDLLIG LPSSGLHCAG FNEILTQLAA SKVNLKERSP
660 670 680 690 700
VDGGDDGLTL AHVLATPTQL YVQQLLPHLQ KGDEIKSVAH VTHGLLNDVL
710 720 730 740 750
RLLPEGFETT LDFGAVPVPK IFGWLAGKLK LSAQTLLERH NCGIGMVLIL
760 770 780 790 800
PQSSQLWRTS LPGAKVLGVL QRRSKVGGSP VQVRNFVEQL EKVASPFGGI
810 820 830 840 850
GDRELPEELK KLPSNSDLTA PREECFENAA GRRLTRIPTH YQDPILILGT
860 870 880 890 900
DGVGTKLKIA QQTNRNTSVG IDLVAMCVND ILCNGAEPIS FSSYYACGLW
910 920 930 940 950
QEQLAKEVHS GVQEGARQAN SSFIDSHSAA LPLLYGPQVY DLAGFALGIA
960 970 980 990 1000
EHCGILPLLD EIQPGDVLIG LPSSGVHSNG FSLVHAVLKR VGLGLHDKAP
1010 1020 1030 1040 1050
FSEKTLGEEL LVPTKIYVQA LSTLLSRGNH GIKALAHITG GGLSENIPRV
1060 1070 1080 1090 1100
LRKDLAVRLD ANKFQLPPVF AWLAAAGNIS STELQRTYNC GLGMVLVVAP
1110 1120 1130 1140 1150
TEVENVLKEL RYPQRAAVVG EVVARKDPKK PQVVVQNFEA SLTRTQKMLS
1160 1170 1180 1190 1200
QRRKRVAVLI SGTGSNLQAL IDATRDSAQG IHAEVVLVIS NKPGVLGLQR
1210 1220 1230 1240 1250
ATQAGIPSLV ISHKDFASRE VYDAELTRNL KAARVDLICL AGFMRVLSAP
1260 1270 1280 1290 1300
FVREWRGRLV NIHPSLLPKY PGLHVQKQAL EAGEKESGCT VHFVDEGVDT
1310 1320 1330 1340 1350
GAIIVQAAVP ILPDDDEDSL TQRIHKAEHW AFPRALAMLA NGTALISPEV

SSQ
Length:1,353
Mass (Da):144,475
Last modified:September 23, 2008 - v1
Checksum:i22C1DC92E49C3DE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000361 Genomic DNA. Translation: EDX04047.1.
CM002910 Genomic DNA. Translation: KMY88683.1.
RefSeqiXP_002078462.1. XM_002078426.2.

Genome annotation databases

EnsemblMetazoaiFBtr0222428; FBpp0220920; FBgn0193920.
GeneIDi6731306.
KEGGidsi:Dsimw501_GD22518.

Similar proteinsi

Entry informationi

Entry nameiB4Q5B4_DROSI
AccessioniPrimary (citable) accession number: B4Q5B4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported