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B4Q0P3

- SWS_DROYA

UniProt

B4Q0P3 - SWS_DROYA

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei991 – 9911By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi174 – 301128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi488 – 615128cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi604 – 731128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GE17492
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002282: Chromosome X, UP000002282: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0234955. Dyak\GE17492.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14671467Neuropathy target esterase swsPRO_0000389229Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei450 – 4501PhosphoserineBy similarity
    Modified residuei459 – 4591PhosphoserineBy similarity
    Modified residuei1205 – 12051PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Protein-protein interaction databases

    STRINGi7245.FBpp0262502.

    Structurei

    3D structure databases

    ProteinModelPortaliB4Q0P3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14671412CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini958 – 1124167PatatinSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi436 – 4394Poly-GlnSequence Analysis

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    KOiK14676.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB4Q0P3.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4Q0P3-1 [UniParc]FASTAAdd to Basket

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    MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATMYMYCA FGLMGVLFLA     50
    WFMYFKRLAR LRLRDELARS ISSVTNSYGD LRGLRFRKRD KMLFYGRRML 100
    RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY 150
    LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLRLCKHT QLLELMAGDY 200
    LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID 250
    VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
    RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQATA 350
    NGPPMVINQL NLMQSAASGL GMGMGTGTGS GVSVTVTRPP PSPSRHSREE 400
    HTLSDPNPNP DGSVHGTSNL FTEVHGDAPN ADLFHQQQQS VGNLSTRRSS 450
    ITQMTPDGSH TCPQAPGVTT SIDMRLVQSS AVDSLRKELG LSEEDAHIIE 500
    PFVELRELEP NVTLITEGNA DDVCVWFVMT GTLAVYQSNQ DATRAKQDKN 550
    DMLIHFVHPG EIVGGLAMLT GEASAYTIRS RSNSRIAFIR RAAIYQIMRQ 600
    RPRIVLDLGN GVVRRLSPLV RQCDYALDWI FLESGRAVYR QDESSDSTYI 650
    VLSGRMRSVI THPGGKKEIV GEYGKGDLVG IVEMITETSR TTTVMAVRDS 700
    ELAKLPEGLF NAIKLRYPIV VTKLISFLSH RFLGSMQTRS GSGAPGAPVE 750
    ANPVTHKYST VALVPITDEV PLTPFTYELY HSLCAIGPVL RLTSDVVRKQ 800
    LGPNIFEAAN EYRLTSWLAQ QEDRNIITLY QCDSSLSAWT QRCMRQADVI 850
    LIVGLGDRSH LVGKFEREID RLAMRTQKEL VLLYPEATNA KPANTLSWLN 900
    ARPWVTKHHH VLCVKRIFTR KSQYRINDLY SRVLLSEPNM HSDFSRLARW 950
    LTGNSIGLVL GGGGARGAAH IGMLKAIQEA GIPVDMVGGV SIGALMGALW 1000
    CSERNITTVT QKAREWSKKM TKWFLQLLDL TYPITSMFSG REFNKTIHDT 1050
    FGDVSIEDLW IPYFTLTTDI TASCHRIHTN GSLWRYVRSS MSLSGYMPPL 1100
    CDPKDGHLLL DGGYVNNLPG HLWRYCRASM SIAGVFPPFC DYRDGHLLLD 1150
    GCYTNNVPAD VMHNLGAAHI IAIDVGSQDD TDLTNYGDDL SGWWLLYKKW 1200
    NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE VKNSDYCEYI RPPIDKYKTL 1250
    AFGSFDEIRD VGYVFGKNYF ENMAKAGRLG RFNQWFNKEP PKRVNHASLN 1300
    EYTFIDLAQI VCRLPETYAV NTAELFSEDE DCDGYISEPT TLNTDRRRIQ 1350
    VPRAGNSLSF SETEMDSDVE LDLKLERKMD KSTQSTPPTS SRASVRGKEE 1400
    ARHMDNWHWS VKHKVETASG ATEATNAMID QEQQHQQQAD QGVGAEQLAD 1450
    KDEDKENRSS TYNETKN 1467
    Length:1,467
    Mass (Da):165,017
    Last modified:September 23, 2008 - v1
    Checksum:iDD679DAE7DA7509F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000162 Genomic DNA. Translation: EDX02314.1.
    RefSeqiXP_002101206.1. XM_002101170.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0264010; FBpp0262502; FBgn0234955.
    GeneIDi6525370.
    KEGGidya:Dyak_GE17492.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000162 Genomic DNA. Translation: EDX02314.1 .
    RefSeqi XP_002101206.1. XM_002101170.1.

    3D structure databases

    ProteinModelPortali B4Q0P3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7245.FBpp0262502.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0264010 ; FBpp0262502 ; FBgn0234955 .
    GeneIDi 6525370.
    KEGGi dya:Dyak_GE17492.

    Organism-specific databases

    FlyBasei FBgn0234955. Dyak\GE17492.

    Phylogenomic databases

    eggNOGi COG0664.
    KOi K14676.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B4Q0P3.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tai18E2 / Tucson 14021-0261.01Imported.

    Entry informationi

    Entry nameiSWS_DROYA
    AccessioniPrimary (citable) accession number: B4Q0P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3