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B4Q0P3

- SWS_DROYA

UniProt

B4Q0P3 - SWS_DROYA

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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei991 – 9911By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 301128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi488 – 615128cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi604 – 731128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GE17492
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome X, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0234955. Dyak\GE17492.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14671467Neuropathy target esterase swsPRO_0000389229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei450 – 4501PhosphoserineBy similarity
Modified residuei459 – 4591PhosphoserineBy similarity
Modified residuei1205 – 12051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0262502.

Structurei

3D structure databases

ProteinModelPortaliB4Q0P3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence AnalysisAdd
BLAST
Topological domaini56 – 14671412CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini958 – 1124167PatatinSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi436 – 4394Poly-GlnSequence Analysis

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4Q0P3.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4Q0P3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATMYMYCA FGLMGVLFLA
60 70 80 90 100
WFMYFKRLAR LRLRDELARS ISSVTNSYGD LRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLRLCKHT QLLELMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQATA
360 370 380 390 400
NGPPMVINQL NLMQSAASGL GMGMGTGTGS GVSVTVTRPP PSPSRHSREE
410 420 430 440 450
HTLSDPNPNP DGSVHGTSNL FTEVHGDAPN ADLFHQQQQS VGNLSTRRSS
460 470 480 490 500
ITQMTPDGSH TCPQAPGVTT SIDMRLVQSS AVDSLRKELG LSEEDAHIIE
510 520 530 540 550
PFVELRELEP NVTLITEGNA DDVCVWFVMT GTLAVYQSNQ DATRAKQDKN
560 570 580 590 600
DMLIHFVHPG EIVGGLAMLT GEASAYTIRS RSNSRIAFIR RAAIYQIMRQ
610 620 630 640 650
RPRIVLDLGN GVVRRLSPLV RQCDYALDWI FLESGRAVYR QDESSDSTYI
660 670 680 690 700
VLSGRMRSVI THPGGKKEIV GEYGKGDLVG IVEMITETSR TTTVMAVRDS
710 720 730 740 750
ELAKLPEGLF NAIKLRYPIV VTKLISFLSH RFLGSMQTRS GSGAPGAPVE
760 770 780 790 800
ANPVTHKYST VALVPITDEV PLTPFTYELY HSLCAIGPVL RLTSDVVRKQ
810 820 830 840 850
LGPNIFEAAN EYRLTSWLAQ QEDRNIITLY QCDSSLSAWT QRCMRQADVI
860 870 880 890 900
LIVGLGDRSH LVGKFEREID RLAMRTQKEL VLLYPEATNA KPANTLSWLN
910 920 930 940 950
ARPWVTKHHH VLCVKRIFTR KSQYRINDLY SRVLLSEPNM HSDFSRLARW
960 970 980 990 1000
LTGNSIGLVL GGGGARGAAH IGMLKAIQEA GIPVDMVGGV SIGALMGALW
1010 1020 1030 1040 1050
CSERNITTVT QKAREWSKKM TKWFLQLLDL TYPITSMFSG REFNKTIHDT
1060 1070 1080 1090 1100
FGDVSIEDLW IPYFTLTTDI TASCHRIHTN GSLWRYVRSS MSLSGYMPPL
1110 1120 1130 1140 1150
CDPKDGHLLL DGGYVNNLPG HLWRYCRASM SIAGVFPPFC DYRDGHLLLD
1160 1170 1180 1190 1200
GCYTNNVPAD VMHNLGAAHI IAIDVGSQDD TDLTNYGDDL SGWWLLYKKW
1210 1220 1230 1240 1250
NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE VKNSDYCEYI RPPIDKYKTL
1260 1270 1280 1290 1300
AFGSFDEIRD VGYVFGKNYF ENMAKAGRLG RFNQWFNKEP PKRVNHASLN
1310 1320 1330 1340 1350
EYTFIDLAQI VCRLPETYAV NTAELFSEDE DCDGYISEPT TLNTDRRRIQ
1360 1370 1380 1390 1400
VPRAGNSLSF SETEMDSDVE LDLKLERKMD KSTQSTPPTS SRASVRGKEE
1410 1420 1430 1440 1450
ARHMDNWHWS VKHKVETASG ATEATNAMID QEQQHQQQAD QGVGAEQLAD
1460
KDEDKENRSS TYNETKN
Length:1,467
Mass (Da):165,017
Last modified:September 23, 2008 - v1
Checksum:iDD679DAE7DA7509F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000162 Genomic DNA. Translation: EDX02314.1.
RefSeqiXP_002101206.1. XM_002101170.1.

Genome annotation databases

EnsemblMetazoaiFBtr0264010; FBpp0262502; FBgn0234955.
GeneIDi6525370.
KEGGidya:Dyak_GE17492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000162 Genomic DNA. Translation: EDX02314.1 .
RefSeqi XP_002101206.1. XM_002101170.1.

3D structure databases

ProteinModelPortali B4Q0P3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7245.FBpp0262502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0264010 ; FBpp0262502 ; FBgn0234955 .
GeneIDi 6525370.
KEGGi dya:Dyak_GE17492.

Organism-specific databases

FlyBasei FBgn0234955. Dyak\GE17492.

Phylogenomic databases

eggNOGi COG0664.
KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4Q0P3.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.

Entry informationi

Entry nameiSWS_DROYA
AccessioniPrimary (citable) accession number: B4Q0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3