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B4Q0P3

- SWS_DROYA

UniProt

B4Q0P3 - SWS_DROYA

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Protein
Neuropathy target esterase sws
Gene
sws, GE17492
Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei991 – 9911 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 301128cNMP 1
Add
BLAST
Nucleotide bindingi488 – 615128cNMP 2
Add
BLAST
Nucleotide bindingi604 – 731128cNMP 3
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GE17492
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome X, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0234955. Dyak\GE17492.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Topological domaini56 – 14671412Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14671467Neuropathy target esterase sws
PRO_0000389229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei450 – 4501Phosphoserine By similarityBy similarity
Modified residuei459 – 4591Phosphoserine By similarityBy similarity
Modified residuei1205 – 12051Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0262502.

Structurei

3D structure databases

ProteinModelPortaliB4Q0P3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini958 – 1124167Patatin
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi436 – 4394Poly-Gln

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4Q0P3.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4Q0P3-1 [UniParc]FASTAAdd to Basket

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MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATMYMYCA FGLMGVLFLA     50
WFMYFKRLAR LRLRDELARS ISSVTNSYGD LRGLRFRKRD KMLFYGRRML 100
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY 150
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLRLCKHT QLLELMAGDY 200
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID 250
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQATA 350
NGPPMVINQL NLMQSAASGL GMGMGTGTGS GVSVTVTRPP PSPSRHSREE 400
HTLSDPNPNP DGSVHGTSNL FTEVHGDAPN ADLFHQQQQS VGNLSTRRSS 450
ITQMTPDGSH TCPQAPGVTT SIDMRLVQSS AVDSLRKELG LSEEDAHIIE 500
PFVELRELEP NVTLITEGNA DDVCVWFVMT GTLAVYQSNQ DATRAKQDKN 550
DMLIHFVHPG EIVGGLAMLT GEASAYTIRS RSNSRIAFIR RAAIYQIMRQ 600
RPRIVLDLGN GVVRRLSPLV RQCDYALDWI FLESGRAVYR QDESSDSTYI 650
VLSGRMRSVI THPGGKKEIV GEYGKGDLVG IVEMITETSR TTTVMAVRDS 700
ELAKLPEGLF NAIKLRYPIV VTKLISFLSH RFLGSMQTRS GSGAPGAPVE 750
ANPVTHKYST VALVPITDEV PLTPFTYELY HSLCAIGPVL RLTSDVVRKQ 800
LGPNIFEAAN EYRLTSWLAQ QEDRNIITLY QCDSSLSAWT QRCMRQADVI 850
LIVGLGDRSH LVGKFEREID RLAMRTQKEL VLLYPEATNA KPANTLSWLN 900
ARPWVTKHHH VLCVKRIFTR KSQYRINDLY SRVLLSEPNM HSDFSRLARW 950
LTGNSIGLVL GGGGARGAAH IGMLKAIQEA GIPVDMVGGV SIGALMGALW 1000
CSERNITTVT QKAREWSKKM TKWFLQLLDL TYPITSMFSG REFNKTIHDT 1050
FGDVSIEDLW IPYFTLTTDI TASCHRIHTN GSLWRYVRSS MSLSGYMPPL 1100
CDPKDGHLLL DGGYVNNLPG HLWRYCRASM SIAGVFPPFC DYRDGHLLLD 1150
GCYTNNVPAD VMHNLGAAHI IAIDVGSQDD TDLTNYGDDL SGWWLLYKKW 1200
NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE VKNSDYCEYI RPPIDKYKTL 1250
AFGSFDEIRD VGYVFGKNYF ENMAKAGRLG RFNQWFNKEP PKRVNHASLN 1300
EYTFIDLAQI VCRLPETYAV NTAELFSEDE DCDGYISEPT TLNTDRRRIQ 1350
VPRAGNSLSF SETEMDSDVE LDLKLERKMD KSTQSTPPTS SRASVRGKEE 1400
ARHMDNWHWS VKHKVETASG ATEATNAMID QEQQHQQQAD QGVGAEQLAD 1450
KDEDKENRSS TYNETKN 1467
Length:1,467
Mass (Da):165,017
Last modified:September 23, 2008 - v1
Checksum:iDD679DAE7DA7509F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000162 Genomic DNA. Translation: EDX02314.1.
RefSeqiXP_002101206.1. XM_002101170.1.

Genome annotation databases

EnsemblMetazoaiFBtr0264010; FBpp0262502; FBgn0234955.
GeneIDi6525370.
KEGGidya:Dyak_GE17492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000162 Genomic DNA. Translation: EDX02314.1 .
RefSeqi XP_002101206.1. XM_002101170.1.

3D structure databases

ProteinModelPortali B4Q0P3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7245.FBpp0262502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0264010 ; FBpp0262502 ; FBgn0234955 .
GeneIDi 6525370.
KEGGi dya:Dyak_GE17492.

Organism-specific databases

FlyBasei FBgn0234955. Dyak\GE17492.

Phylogenomic databases

eggNOGi COG0664.
KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4Q0P3.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01.

Entry informationi

Entry nameiSWS_DROYA
AccessioniPrimary (citable) accession number: B4Q0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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