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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei991NucleophilePROSITE-ProRule annotation1
Active sitei1111Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi174 – 301cNMP 1Sequence analysisAdd BLAST128
Nucleotide bindingi488 – 615cNMP 2Sequence analysisAdd BLAST128
Nucleotide bindingi604 – 731cNMP 3Sequence analysisAdd BLAST128

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hydrolase
Biological processLipid degradation, Lipid metabolism, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GE17492
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0234955 Dyak\GE17492

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34LumenalSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 1467CytoplasmicSequence analysisAdd BLAST1412

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003892291 – 1467Neuropathy target esterase swsAdd BLAST1467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei450PhosphoserineBy similarity1
Modified residuei459PhosphoserineBy similarity1
Modified residuei1205PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

BgeeiFBgn0234955

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7245.FBpp0262502

Structurei

3D structure databases

ProteinModelPortaliB4Q0P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini958 – 1124PNPLAPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi962 – 967GXGXXGPROSITE-ProRule annotation6
Motifi989 – 993GXSXGPROSITE-ProRule annotation5
Motifi1111 – 1113DGA/GPROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi436 – 439Poly-GlnSequence analysis4

Sequence similaritiesi

Belongs to the NTE family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2968 Eukaryota
COG0664 LUCA
COG1752 LUCA
KOiK14676
OMAiQVLGVMI
OrthoDBiEOG091G00XM
PhylomeDBiB4Q0P3

Family and domain databases

CDDicd00038 CAP_ED, 3 hits
Gene3Di2.60.120.10, 3 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 3 hits
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 3 hits
SUPFAMiSSF51206 SSF51206, 3 hits
SSF52151 SSF52151, 2 hits
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 3 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

Sequencei

Sequence statusi: Complete.

B4Q0P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATMYMYCA FGLMGVLFLA
60 70 80 90 100
WFMYFKRLAR LRLRDELARS ISSVTNSYGD LRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLRLCKHT QLLELMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQATA
360 370 380 390 400
NGPPMVINQL NLMQSAASGL GMGMGTGTGS GVSVTVTRPP PSPSRHSREE
410 420 430 440 450
HTLSDPNPNP DGSVHGTSNL FTEVHGDAPN ADLFHQQQQS VGNLSTRRSS
460 470 480 490 500
ITQMTPDGSH TCPQAPGVTT SIDMRLVQSS AVDSLRKELG LSEEDAHIIE
510 520 530 540 550
PFVELRELEP NVTLITEGNA DDVCVWFVMT GTLAVYQSNQ DATRAKQDKN
560 570 580 590 600
DMLIHFVHPG EIVGGLAMLT GEASAYTIRS RSNSRIAFIR RAAIYQIMRQ
610 620 630 640 650
RPRIVLDLGN GVVRRLSPLV RQCDYALDWI FLESGRAVYR QDESSDSTYI
660 670 680 690 700
VLSGRMRSVI THPGGKKEIV GEYGKGDLVG IVEMITETSR TTTVMAVRDS
710 720 730 740 750
ELAKLPEGLF NAIKLRYPIV VTKLISFLSH RFLGSMQTRS GSGAPGAPVE
760 770 780 790 800
ANPVTHKYST VALVPITDEV PLTPFTYELY HSLCAIGPVL RLTSDVVRKQ
810 820 830 840 850
LGPNIFEAAN EYRLTSWLAQ QEDRNIITLY QCDSSLSAWT QRCMRQADVI
860 870 880 890 900
LIVGLGDRSH LVGKFEREID RLAMRTQKEL VLLYPEATNA KPANTLSWLN
910 920 930 940 950
ARPWVTKHHH VLCVKRIFTR KSQYRINDLY SRVLLSEPNM HSDFSRLARW
960 970 980 990 1000
LTGNSIGLVL GGGGARGAAH IGMLKAIQEA GIPVDMVGGV SIGALMGALW
1010 1020 1030 1040 1050
CSERNITTVT QKAREWSKKM TKWFLQLLDL TYPITSMFSG REFNKTIHDT
1060 1070 1080 1090 1100
FGDVSIEDLW IPYFTLTTDI TASCHRIHTN GSLWRYVRSS MSLSGYMPPL
1110 1120 1130 1140 1150
CDPKDGHLLL DGGYVNNLPG HLWRYCRASM SIAGVFPPFC DYRDGHLLLD
1160 1170 1180 1190 1200
GCYTNNVPAD VMHNLGAAHI IAIDVGSQDD TDLTNYGDDL SGWWLLYKKW
1210 1220 1230 1240 1250
NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE VKNSDYCEYI RPPIDKYKTL
1260 1270 1280 1290 1300
AFGSFDEIRD VGYVFGKNYF ENMAKAGRLG RFNQWFNKEP PKRVNHASLN
1310 1320 1330 1340 1350
EYTFIDLAQI VCRLPETYAV NTAELFSEDE DCDGYISEPT TLNTDRRRIQ
1360 1370 1380 1390 1400
VPRAGNSLSF SETEMDSDVE LDLKLERKMD KSTQSTPPTS SRASVRGKEE
1410 1420 1430 1440 1450
ARHMDNWHWS VKHKVETASG ATEATNAMID QEQQHQQQAD QGVGAEQLAD
1460
KDEDKENRSS TYNETKN
Length:1,467
Mass (Da):165,017
Last modified:September 23, 2008 - v1
Checksum:iDD679DAE7DA7509F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000162 Genomic DNA Translation: EDX02314.1
RefSeqiXP_002101206.2, XM_002101170.2

Genome annotation databases

GeneIDi6525370
KEGGidya:Dyak_GE17492

Similar proteinsi

Entry informationi

Entry nameiSWS_DROYA
AccessioniPrimary (citable) accession number: B4Q0P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health