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B4PY69 (PGAM5_DROYA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene names
Name:Pgam5
ORF Names:GE16503
OrganismDrosophila yakuba (Fruit fly) [Complete proteome]
Taxonomic identifier7245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity. UniProtKB O46084

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with Pk92B/ASK1 By similarity. UniProtKB O46084

Subcellular location

Mitochondrion outer membrane By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion outer membrane
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentmitochondrial outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000390712

Sequences

Sequence LengthMass (Da)Tools
B4PY69 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 02BF1E5205DE3728

FASTA28933,139
        10         20         30         40         50         60 
MRKLTSFVCG TGAGFAAYYL QRLRDPQAAV HNSWTNSDKP VDPWALWDTN WDCREPRALV 

        70         80         90        100        110        120 
RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV GDSDDTHHLT DRGRKQAEFT 

       130        140        150        160        170        180 
GKRLSELGIK WDKIVASTMV RAQETSDIIL KQIEFEKEKV VNCAFLREGA PIPPQPPVGH 

       190        200        210        220        230        240 
WKPEASQFLR DGSRIEAAFR RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW 

       250        260        270        280 
LRISINHASI TWLTISPSGN VSIKYLGDSG FMPPELLTNR IPRDVKNVV 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tai18E2 / Tucson 14021-0261.01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000162 Genomic DNA. Translation: EDX00942.1.
RefSeqXP_002099834.1. XM_002099798.1.

3D structure databases

ProteinModelPortalB4PY69.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7245.FBpp0261513.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0263021; FBpp0261513; FBgn0234020.
GeneID6523962.
KEGGdya:Dyak_GE16503.

Organism-specific databases

FlyBaseFBgn0234020. Dyak\GE16503.

Phylogenomic databases

eggNOGNOG71348.
KOK15637.
OrthoDBEOG7966H1.
PhylomeDBB4PY69.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGAM5_DROYA
AccessionPrimary (citable) accession number: B4PY69
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase