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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homologBy similarity
Gene namesi
Name:Pgam5By similarity
ORF Names:GE16503
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome X, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0234020. Dyak\GE16503.

Subcellular locationi

Mitochondrion outer membrane By similarity

GO - Cellular componenti

  1. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390712Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0261513.

Structurei

3D structure databases

ProteinModelPortaliB4PY69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG71348.
KOiK15637.
OMAiEIIVCHA.
OrthoDBiEOG7966H1.
PhylomeDBiB4PY69.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

B4PY69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLTSFVCG TGAGFAAYYL QRLRDPQAAV HNSWTNSDKP VDPWALWDTN
60 70 80 90 100
WDCREPRALV RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV
110 120 130 140 150
GDSDDTHHLT DRGRKQAEFT GKRLSELGIK WDKIVASTMV RAQETSDIIL
160 170 180 190 200
KQIEFEKEKV VNCAFLREGA PIPPQPPVGH WKPEASQFLR DGSRIEAAFR
210 220 230 240 250
RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW LRISINHASI
260 270 280
TWLTISPSGN VSIKYLGDSG FMPPELLTNR IPRDVKNVV
Length:289
Mass (Da):33,139
Last modified:September 23, 2008 - v1
Checksum:i02BF1E5205DE3728
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000162 Genomic DNA. Translation: EDX00942.1.
RefSeqiXP_002099834.1. XM_002099798.1.

Genome annotation databases

EnsemblMetazoaiFBtr0263021; FBpp0261513; FBgn0234020.
GeneIDi6523962.
KEGGidya:Dyak_GE16503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000162 Genomic DNA. Translation: EDX00942.1.
RefSeqiXP_002099834.1. XM_002099798.1.

3D structure databases

ProteinModelPortaliB4PY69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0261513.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0263021; FBpp0261513; FBgn0234020.
GeneIDi6523962.
KEGGidya:Dyak_GE16503.

Organism-specific databases

FlyBaseiFBgn0234020. Dyak\GE16503.

Phylogenomic databases

eggNOGiNOG71348.
KOiK15637.
OMAiEIIVCHA.
OrthoDBiEOG7966H1.
PhylomeDBiB4PY69.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.

Entry informationi

Entry nameiPGAM5_DROYA
AccessioniPrimary (citable) accession number: B4PY69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.