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B4PY69

- PGAM5_DROYA

UniProt

B4PY69 - PGAM5_DROYA

Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5 homologBy similarity
    Gene namesi
    Name:Pgam5By similarity
    ORF Names:GE16503
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002282: Chromosome X, UP000002282: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0234020. Dyak\GE16503.

    Subcellular locationi

    Mitochondrion outer membrane By similarity

    GO - Cellular componenti

    1. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390712Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with Pk92B/ASK1.By similarity

    Protein-protein interaction databases

    STRINGi7245.FBpp0261513.

    Structurei

    3D structure databases

    ProteinModelPortaliB4PY69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG71348.
    KOiK15637.
    OrthoDBiEOG7966H1.
    PhylomeDBiB4PY69.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4PY69-1 [UniParc]FASTAAdd to Basket

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    MRKLTSFVCG TGAGFAAYYL QRLRDPQAAV HNSWTNSDKP VDPWALWDTN    50
    WDCREPRALV RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV 100
    GDSDDTHHLT DRGRKQAEFT GKRLSELGIK WDKIVASTMV RAQETSDIIL 150
    KQIEFEKEKV VNCAFLREGA PIPPQPPVGH WKPEASQFLR DGSRIEAAFR 200
    RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW LRISINHASI 250
    TWLTISPSGN VSIKYLGDSG FMPPELLTNR IPRDVKNVV 289
    Length:289
    Mass (Da):33,139
    Last modified:September 23, 2008 - v1
    Checksum:i02BF1E5205DE3728
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000162 Genomic DNA. Translation: EDX00942.1.
    RefSeqiXP_002099834.1. XM_002099798.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0263021; FBpp0261513; FBgn0234020.
    GeneIDi6523962.
    KEGGidya:Dyak_GE16503.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000162 Genomic DNA. Translation: EDX00942.1 .
    RefSeqi XP_002099834.1. XM_002099798.1.

    3D structure databases

    ProteinModelPortali B4PY69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7245.FBpp0261513.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0263021 ; FBpp0261513 ; FBgn0234020 .
    GeneIDi 6523962.
    KEGGi dya:Dyak_GE16503.

    Organism-specific databases

    FlyBasei FBgn0234020. Dyak\GE16503.

    Phylogenomic databases

    eggNOGi NOG71348.
    KOi K15637.
    OrthoDBi EOG7966H1.
    PhylomeDBi B4PY69.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tai18E2 / Tucson 14021-0261.01Imported.

    Entry informationi

    Entry nameiPGAM5_DROYA
    AccessioniPrimary (citable) accession number: B4PY69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3