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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei749Proton donorBy similarity1
Metal bindingi753Divalent metal cation 1By similarity1
Metal bindingi789Divalent metal cation 1By similarity1
Metal bindingi790Divalent metal cation 1By similarity1
Metal bindingi790Divalent metal cation 2By similarity1
Metal bindingi900Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GE26445
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componentsi: Chromosome 3R, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0243466 Dyak\GE26445

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003637041 – 1146cGMP-specific 3',5'-cyclic phosphodiesteraseAdd BLAST1146
PropeptideiPRO_00003637051147 – 1149Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1146Cysteine methyl esterBy similarity1
Lipidationi1146S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Expressioni

Gene expression databases

BgeeiFBgn0243466

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0271455

Structurei

3D structure databases

ProteinModelPortaliB4PSS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 430GAF 1Sequence analysisAdd BLAST153
Domaini462 – 643GAF 2Sequence analysisAdd BLAST182
Domaini673 – 996PDEasePROSITE-ProRule annotationAdd BLAST324

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 150Ser-richSequence analysisAdd BLAST145

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
KOiK13763
OMAiATIRMFK
OrthoDBiEOG091G04JU
PhylomeDBiB4PSS5

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 1 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4PSS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGTVSRSSS SSNMTDVSSP AGGAASPVEI ATSSSTAATT SASASSSKPL
60 70 80 90 100
TNGANKTAIS TAAGVTPGAA PGPGCAAIPA SGSSGNQVKL EHHYRQSNNN
110 120 130 140 150
RPAGSNRSSE TKLRSPAGES DGASRLMTPA GSSSSPSQSP SQSQSQSQAS
160 170 180 190 200
IQTQTSQQDR LVKAPSTTAS QQDVDEVARL FEEKPEAFEK WLTERAPPEA
210 220 230 240 250
LSRLQEFIEN RKPHKRPSVT SDLFQQWMAA SPTVQQKSPR SLSNSSASSL
260 270 280 290 300
PECRRHLMDL DEGELFMELI RDVANELDID VLCHKILVNV GLLTHADRGS
310 320 330 340 350
LFLAKGTPTN KYLVAKLFDV TQKTALKDAV TRASAEEIII PFGIGIAGMV
360 370 380 390 400
AQTKQMINIK EAYKDARFNC EIDLKTGYKT NAILCMPICN YEGDIIGVAQ
410 420 430 440 450
IINKTNGCME FDEHDVEIFR RYLTFCGIGI QNAQLFEMSV QEYRRNQILL
460 470 480 490 500
NLARSIFEEQ NNLECLVTKI MTEARELLKC ERCSVFLVDL DCCEASHLEK
510 520 530 540 550
IIEKPNQPAT RAIKSADSFE EKKMRNRFTV LFELGGEYQA ANVSRPSVSE
560 570 580 590 600
LSSSTLAQIA QFVATTGQTV NICDVIEWVR DHNQIRAEDE IDSTQAILCM
610 620 630 640 650
PIMNAQKKVI GVAQLINKAN GVPFTESDAS IFEAFAIFCG LGIHNTQMYE
660 670 680 690 700
NACKLMAKQK VALECLSYHA TASQDQTEKL TQDAIAEAES YNLYSFTFTD
710 720 730 740 750
FELVDDDTCR AVLRMFMQCN LVSQFQIPYD VLCRWVLSVR KNYRPVKYHN
760 770 780 790 800
WRHALNVAQT MFAMLKTGKM ERFMTDLEIL GLLVACLCHD LDHRGTNNAF
810 820 830 840 850
QTKTESPLAI LYTTSTMEHH HFDQCVMILN SEGNNIFQAL SPEDYRSVMK
860 870 880 890 900
TVESAILSTD LAMYFKKRNA FLELVENGEF DWQGEEKKDL LCGMMMTACD
910 920 930 940 950
VSAIAKPWEV QHKVAKLVAD EFFDQGDLEK LQLNTQPVAM MDRERKDELP
960 970 980 990 1000
KMQVGFIDVI CLPLYRVLCD TFPWITPLYE GTLENRRNWQ DLAEKVEMGL
1010 1020 1030 1040 1050
TWIDHDTIDK PVEEFAACAD EEIKDIEFTV TTLNCNQQSQ HGSEDSHTPE
1060 1070 1080 1090 1100
HQRSGSRLSM KKTGALGKAV RSKLSKTLYN SMDGSKPKTS LKLLESHVSE
1110 1120 1130 1140
DMDDKSPTSP SQPQASGSMG RMSASSSTSS AGGQMVDKSK KRSKLCALL
Length:1,149
Mass (Da):127,347
Last modified:September 23, 2008 - v1
Checksum:i96E9219B5B84983C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA Translation: EDW97571.1
RefSeqiXP_002097859.1, XM_002097823.2

Genome annotation databases

EnsemblMetazoaiFBtr0272963; FBpp0271455; FBgn0243466
GeneIDi6537301
KEGGidya:Dyak_GE26445

Similar proteinsi

Entry informationi

Entry nameiPDE6_DROYA
AccessioniPrimary (citable) accession number: B4PSS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health