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B4PSS5

- PDE6_DROYA

UniProt

B4PSS5 - PDE6_DROYA

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei749 – 7491Proton donorBy similarity
    Metal bindingi753 – 7531Divalent metal cation 1By similarity
    Metal bindingi789 – 7891Divalent metal cation 1By similarity
    Metal bindingi790 – 7901Divalent metal cation 1By similarity
    Metal bindingi790 – 7901Divalent metal cation 2By similarity
    Metal bindingi900 – 9001Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GE26445
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002282: Chromosome 3R, UP000002282: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0243466. Dyak\GE26445.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11461146cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363704Add
    BLAST
    Propeptidei1147 – 11493Removed in mature formBy similarityPRO_0000363705

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1146 – 11461Cysteine methyl esterBy similarity
    Lipidationi1146 – 11461S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Protein-protein interaction databases

    STRINGi7245.FBpp0271455.

    Structurei

    3D structure databases

    ProteinModelPortaliB4PSS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini278 – 430153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini462 – 643182GAF 2Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 150145Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG270709.
    KOiK13763.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB4PSS5.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4PSS5-1 [UniParc]FASTAAdd to Basket

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    MHGTVSRSSS SSNMTDVSSP AGGAASPVEI ATSSSTAATT SASASSSKPL     50
    TNGANKTAIS TAAGVTPGAA PGPGCAAIPA SGSSGNQVKL EHHYRQSNNN 100
    RPAGSNRSSE TKLRSPAGES DGASRLMTPA GSSSSPSQSP SQSQSQSQAS 150
    IQTQTSQQDR LVKAPSTTAS QQDVDEVARL FEEKPEAFEK WLTERAPPEA 200
    LSRLQEFIEN RKPHKRPSVT SDLFQQWMAA SPTVQQKSPR SLSNSSASSL 250
    PECRRHLMDL DEGELFMELI RDVANELDID VLCHKILVNV GLLTHADRGS 300
    LFLAKGTPTN KYLVAKLFDV TQKTALKDAV TRASAEEIII PFGIGIAGMV 350
    AQTKQMINIK EAYKDARFNC EIDLKTGYKT NAILCMPICN YEGDIIGVAQ 400
    IINKTNGCME FDEHDVEIFR RYLTFCGIGI QNAQLFEMSV QEYRRNQILL 450
    NLARSIFEEQ NNLECLVTKI MTEARELLKC ERCSVFLVDL DCCEASHLEK 500
    IIEKPNQPAT RAIKSADSFE EKKMRNRFTV LFELGGEYQA ANVSRPSVSE 550
    LSSSTLAQIA QFVATTGQTV NICDVIEWVR DHNQIRAEDE IDSTQAILCM 600
    PIMNAQKKVI GVAQLINKAN GVPFTESDAS IFEAFAIFCG LGIHNTQMYE 650
    NACKLMAKQK VALECLSYHA TASQDQTEKL TQDAIAEAES YNLYSFTFTD 700
    FELVDDDTCR AVLRMFMQCN LVSQFQIPYD VLCRWVLSVR KNYRPVKYHN 750
    WRHALNVAQT MFAMLKTGKM ERFMTDLEIL GLLVACLCHD LDHRGTNNAF 800
    QTKTESPLAI LYTTSTMEHH HFDQCVMILN SEGNNIFQAL SPEDYRSVMK 850
    TVESAILSTD LAMYFKKRNA FLELVENGEF DWQGEEKKDL LCGMMMTACD 900
    VSAIAKPWEV QHKVAKLVAD EFFDQGDLEK LQLNTQPVAM MDRERKDELP 950
    KMQVGFIDVI CLPLYRVLCD TFPWITPLYE GTLENRRNWQ DLAEKVEMGL 1000
    TWIDHDTIDK PVEEFAACAD EEIKDIEFTV TTLNCNQQSQ HGSEDSHTPE 1050
    HQRSGSRLSM KKTGALGKAV RSKLSKTLYN SMDGSKPKTS LKLLESHVSE 1100
    DMDDKSPTSP SQPQASGSMG RMSASSSTSS AGGQMVDKSK KRSKLCALL 1149
    Length:1,149
    Mass (Da):127,347
    Last modified:September 23, 2008 - v1
    Checksum:i96E9219B5B84983C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000160 Genomic DNA. Translation: EDW97571.1.
    RefSeqiXP_002097859.1. XM_002097823.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0272963; FBpp0271455; FBgn0243466.
    GeneIDi6537301.
    KEGGidya:Dyak_GE26445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000160 Genomic DNA. Translation: EDW97571.1 .
    RefSeqi XP_002097859.1. XM_002097823.1.

    3D structure databases

    ProteinModelPortali B4PSS5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7245.FBpp0271455.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0272963 ; FBpp0271455 ; FBgn0243466 .
    GeneIDi 6537301.
    KEGGi dya:Dyak_GE26445.

    Organism-specific databases

    FlyBasei FBgn0243466. Dyak\GE26445.

    Phylogenomic databases

    eggNOGi NOG270709.
    KOi K13763.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B4PSS5.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tai18E2 / Tucson 14021-0261.01Imported.

    Entry informationi

    Entry nameiPDE6_DROYA
    AccessioniPrimary (citable) accession number: B4PSS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3