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B4PSS5

- PDE6_DROYA

UniProt

B4PSS5 - PDE6_DROYA

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei749 – 7491Proton donorBy similarity
Metal bindingi753 – 7531Divalent metal cation 1By similarity
Metal bindingi789 – 7891Divalent metal cation 1By similarity
Metal bindingi790 – 7901Divalent metal cation 1By similarity
Metal bindingi790 – 7901Divalent metal cation 2By similarity
Metal bindingi900 – 9001Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GE26445
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3R, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0243466. Dyak\GE26445.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11461146cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363704Add
BLAST
Propeptidei1147 – 11493Removed in mature formBy similarityPRO_0000363705

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1146 – 11461Cysteine methyl esterBy similarity
Lipidationi1146 – 11461S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0271455.

Structurei

3D structure databases

ProteinModelPortaliB4PSS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 430153GAF 1Sequence AnalysisAdd
BLAST
Domaini462 – 643182GAF 2Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 150145Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4PSS5.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4PSS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGTVSRSSS SSNMTDVSSP AGGAASPVEI ATSSSTAATT SASASSSKPL
60 70 80 90 100
TNGANKTAIS TAAGVTPGAA PGPGCAAIPA SGSSGNQVKL EHHYRQSNNN
110 120 130 140 150
RPAGSNRSSE TKLRSPAGES DGASRLMTPA GSSSSPSQSP SQSQSQSQAS
160 170 180 190 200
IQTQTSQQDR LVKAPSTTAS QQDVDEVARL FEEKPEAFEK WLTERAPPEA
210 220 230 240 250
LSRLQEFIEN RKPHKRPSVT SDLFQQWMAA SPTVQQKSPR SLSNSSASSL
260 270 280 290 300
PECRRHLMDL DEGELFMELI RDVANELDID VLCHKILVNV GLLTHADRGS
310 320 330 340 350
LFLAKGTPTN KYLVAKLFDV TQKTALKDAV TRASAEEIII PFGIGIAGMV
360 370 380 390 400
AQTKQMINIK EAYKDARFNC EIDLKTGYKT NAILCMPICN YEGDIIGVAQ
410 420 430 440 450
IINKTNGCME FDEHDVEIFR RYLTFCGIGI QNAQLFEMSV QEYRRNQILL
460 470 480 490 500
NLARSIFEEQ NNLECLVTKI MTEARELLKC ERCSVFLVDL DCCEASHLEK
510 520 530 540 550
IIEKPNQPAT RAIKSADSFE EKKMRNRFTV LFELGGEYQA ANVSRPSVSE
560 570 580 590 600
LSSSTLAQIA QFVATTGQTV NICDVIEWVR DHNQIRAEDE IDSTQAILCM
610 620 630 640 650
PIMNAQKKVI GVAQLINKAN GVPFTESDAS IFEAFAIFCG LGIHNTQMYE
660 670 680 690 700
NACKLMAKQK VALECLSYHA TASQDQTEKL TQDAIAEAES YNLYSFTFTD
710 720 730 740 750
FELVDDDTCR AVLRMFMQCN LVSQFQIPYD VLCRWVLSVR KNYRPVKYHN
760 770 780 790 800
WRHALNVAQT MFAMLKTGKM ERFMTDLEIL GLLVACLCHD LDHRGTNNAF
810 820 830 840 850
QTKTESPLAI LYTTSTMEHH HFDQCVMILN SEGNNIFQAL SPEDYRSVMK
860 870 880 890 900
TVESAILSTD LAMYFKKRNA FLELVENGEF DWQGEEKKDL LCGMMMTACD
910 920 930 940 950
VSAIAKPWEV QHKVAKLVAD EFFDQGDLEK LQLNTQPVAM MDRERKDELP
960 970 980 990 1000
KMQVGFIDVI CLPLYRVLCD TFPWITPLYE GTLENRRNWQ DLAEKVEMGL
1010 1020 1030 1040 1050
TWIDHDTIDK PVEEFAACAD EEIKDIEFTV TTLNCNQQSQ HGSEDSHTPE
1060 1070 1080 1090 1100
HQRSGSRLSM KKTGALGKAV RSKLSKTLYN SMDGSKPKTS LKLLESHVSE
1110 1120 1130 1140
DMDDKSPTSP SQPQASGSMG RMSASSSTSS AGGQMVDKSK KRSKLCALL
Length:1,149
Mass (Da):127,347
Last modified:September 23, 2008 - v1
Checksum:i96E9219B5B84983C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW97571.1.
RefSeqiXP_002097859.1. XM_002097823.1.

Genome annotation databases

EnsemblMetazoaiFBtr0272963; FBpp0271455; FBgn0243466.
GeneIDi6537301.
KEGGidya:Dyak_GE26445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW97571.1 .
RefSeqi XP_002097859.1. XM_002097823.1.

3D structure databases

ProteinModelPortali B4PSS5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7245.FBpp0271455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0272963 ; FBpp0271455 ; FBgn0243466 .
GeneIDi 6537301.
KEGGi dya:Dyak_GE26445.

Organism-specific databases

FlyBasei FBgn0243466. Dyak\GE26445.

Phylogenomic databases

eggNOGi NOG270709.
KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4PSS5.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.

Entry informationi

Entry nameiPDE6_DROYA
AccessioniPrimary (citable) accession number: B4PSS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3