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B4PSS5

- PDE6_DROYA

UniProt

B4PSS5 - PDE6_DROYA

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene
Pde6, GE26445
Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei749 – 7491Proton donor By similarity
Metal bindingi753 – 7531Divalent metal cation 1 By similarity
Metal bindingi789 – 7891Divalent metal cation 1 By similarity
Metal bindingi790 – 7901Divalent metal cation 1 By similarity
Metal bindingi790 – 7901Divalent metal cation 2 By similarity
Metal bindingi900 – 9001Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GE26445
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3R, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0243466. Dyak\GE26445.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11461146cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarityPRO_0000363704Add
BLAST
Propeptidei1147 – 11493Removed in mature form By similarityBy similarityPRO_0000363705

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1146 – 11461Cysteine methyl ester By similarityBy similarity
Lipidationi1146 – 11461S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0271455.

Structurei

3D structure databases

ProteinModelPortaliB4PSS5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 430153GAF 1Add
BLAST
Domaini462 – 643182GAF 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 150145Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4PSS5.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4PSS5-1 [UniParc]FASTAAdd to Basket

« Hide

MHGTVSRSSS SSNMTDVSSP AGGAASPVEI ATSSSTAATT SASASSSKPL     50
TNGANKTAIS TAAGVTPGAA PGPGCAAIPA SGSSGNQVKL EHHYRQSNNN 100
RPAGSNRSSE TKLRSPAGES DGASRLMTPA GSSSSPSQSP SQSQSQSQAS 150
IQTQTSQQDR LVKAPSTTAS QQDVDEVARL FEEKPEAFEK WLTERAPPEA 200
LSRLQEFIEN RKPHKRPSVT SDLFQQWMAA SPTVQQKSPR SLSNSSASSL 250
PECRRHLMDL DEGELFMELI RDVANELDID VLCHKILVNV GLLTHADRGS 300
LFLAKGTPTN KYLVAKLFDV TQKTALKDAV TRASAEEIII PFGIGIAGMV 350
AQTKQMINIK EAYKDARFNC EIDLKTGYKT NAILCMPICN YEGDIIGVAQ 400
IINKTNGCME FDEHDVEIFR RYLTFCGIGI QNAQLFEMSV QEYRRNQILL 450
NLARSIFEEQ NNLECLVTKI MTEARELLKC ERCSVFLVDL DCCEASHLEK 500
IIEKPNQPAT RAIKSADSFE EKKMRNRFTV LFELGGEYQA ANVSRPSVSE 550
LSSSTLAQIA QFVATTGQTV NICDVIEWVR DHNQIRAEDE IDSTQAILCM 600
PIMNAQKKVI GVAQLINKAN GVPFTESDAS IFEAFAIFCG LGIHNTQMYE 650
NACKLMAKQK VALECLSYHA TASQDQTEKL TQDAIAEAES YNLYSFTFTD 700
FELVDDDTCR AVLRMFMQCN LVSQFQIPYD VLCRWVLSVR KNYRPVKYHN 750
WRHALNVAQT MFAMLKTGKM ERFMTDLEIL GLLVACLCHD LDHRGTNNAF 800
QTKTESPLAI LYTTSTMEHH HFDQCVMILN SEGNNIFQAL SPEDYRSVMK 850
TVESAILSTD LAMYFKKRNA FLELVENGEF DWQGEEKKDL LCGMMMTACD 900
VSAIAKPWEV QHKVAKLVAD EFFDQGDLEK LQLNTQPVAM MDRERKDELP 950
KMQVGFIDVI CLPLYRVLCD TFPWITPLYE GTLENRRNWQ DLAEKVEMGL 1000
TWIDHDTIDK PVEEFAACAD EEIKDIEFTV TTLNCNQQSQ HGSEDSHTPE 1050
HQRSGSRLSM KKTGALGKAV RSKLSKTLYN SMDGSKPKTS LKLLESHVSE 1100
DMDDKSPTSP SQPQASGSMG RMSASSSTSS AGGQMVDKSK KRSKLCALL 1149
Length:1,149
Mass (Da):127,347
Last modified:September 23, 2008 - v1
Checksum:i96E9219B5B84983C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW97571.1.
RefSeqiXP_002097859.1. XM_002097823.1.

Genome annotation databases

EnsemblMetazoaiFBtr0272963; FBpp0271455; FBgn0243466.
GeneIDi6537301.
KEGGidya:Dyak_GE26445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW97571.1 .
RefSeqi XP_002097859.1. XM_002097823.1.

3D structure databases

ProteinModelPortali B4PSS5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7245.FBpp0271455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0272963 ; FBpp0271455 ; FBgn0243466 .
GeneIDi 6537301.
KEGGi dya:Dyak_GE26445.

Organism-specific databases

FlyBasei FBgn0243466. Dyak\GE26445.

Phylogenomic databases

eggNOGi NOG270709.
KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4PSS5.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01.

Entry informationi

Entry nameiPDE6_DROYA
AccessioniPrimary (citable) accession number: B4PSS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi