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B4PSS5 (PDE6_DROYA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase

EC=3.1.4.35
Gene names
Name:Pde6
ORF Names:GE26445
OrganismDrosophila yakuba (Fruit fly) [Complete proteome]
Taxonomic identifier7245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1149 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity. UniProtKB Q9VFI9

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. UniProtKB Q9VFI9

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Subunit structure

Interacts with PrBP By similarity. UniProtKB Q9VFI9

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity UniProtKB Q9VFI9.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Contains 2 GAF domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11461146cGMP-specific 3',5'-cyclic phosphodiesterase UniProtKB Q9VFI9
PRO_0000363704
Propeptide1147 – 11493Removed in mature form By similarity UniProtKB Q9VFI9
PRO_0000363705

Regions

Domain278 – 430153GAF 1
Domain462 – 643182GAF 2
Compositional bias6 – 150145Ser-rich

Sites

Active site7491Proton donor By similarity
Metal binding7531Divalent metal cation 1 By similarity
Metal binding7891Divalent metal cation 1 By similarity
Metal binding7901Divalent metal cation 1 By similarity
Metal binding7901Divalent metal cation 2 By similarity
Metal binding9001Divalent metal cation 1 By similarity

Amino acid modifications

Modified residue11461Cysteine methyl ester By similarity UniProtKB Q9VFI9
Lipidation11461S-farnesyl cysteine By similarity UniProtKB Q9VFI9

Sequences

Sequence LengthMass (Da)Tools
B4PSS5 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 96E9219B5B84983C

FASTA1,149127,347
        10         20         30         40         50         60 
MHGTVSRSSS SSNMTDVSSP AGGAASPVEI ATSSSTAATT SASASSSKPL TNGANKTAIS 

        70         80         90        100        110        120 
TAAGVTPGAA PGPGCAAIPA SGSSGNQVKL EHHYRQSNNN RPAGSNRSSE TKLRSPAGES 

       130        140        150        160        170        180 
DGASRLMTPA GSSSSPSQSP SQSQSQSQAS IQTQTSQQDR LVKAPSTTAS QQDVDEVARL 

       190        200        210        220        230        240 
FEEKPEAFEK WLTERAPPEA LSRLQEFIEN RKPHKRPSVT SDLFQQWMAA SPTVQQKSPR 

       250        260        270        280        290        300 
SLSNSSASSL PECRRHLMDL DEGELFMELI RDVANELDID VLCHKILVNV GLLTHADRGS 

       310        320        330        340        350        360 
LFLAKGTPTN KYLVAKLFDV TQKTALKDAV TRASAEEIII PFGIGIAGMV AQTKQMINIK 

       370        380        390        400        410        420 
EAYKDARFNC EIDLKTGYKT NAILCMPICN YEGDIIGVAQ IINKTNGCME FDEHDVEIFR 

       430        440        450        460        470        480 
RYLTFCGIGI QNAQLFEMSV QEYRRNQILL NLARSIFEEQ NNLECLVTKI MTEARELLKC 

       490        500        510        520        530        540 
ERCSVFLVDL DCCEASHLEK IIEKPNQPAT RAIKSADSFE EKKMRNRFTV LFELGGEYQA 

       550        560        570        580        590        600 
ANVSRPSVSE LSSSTLAQIA QFVATTGQTV NICDVIEWVR DHNQIRAEDE IDSTQAILCM 

       610        620        630        640        650        660 
PIMNAQKKVI GVAQLINKAN GVPFTESDAS IFEAFAIFCG LGIHNTQMYE NACKLMAKQK 

       670        680        690        700        710        720 
VALECLSYHA TASQDQTEKL TQDAIAEAES YNLYSFTFTD FELVDDDTCR AVLRMFMQCN 

       730        740        750        760        770        780 
LVSQFQIPYD VLCRWVLSVR KNYRPVKYHN WRHALNVAQT MFAMLKTGKM ERFMTDLEIL 

       790        800        810        820        830        840 
GLLVACLCHD LDHRGTNNAF QTKTESPLAI LYTTSTMEHH HFDQCVMILN SEGNNIFQAL 

       850        860        870        880        890        900 
SPEDYRSVMK TVESAILSTD LAMYFKKRNA FLELVENGEF DWQGEEKKDL LCGMMMTACD 

       910        920        930        940        950        960 
VSAIAKPWEV QHKVAKLVAD EFFDQGDLEK LQLNTQPVAM MDRERKDELP KMQVGFIDVI 

       970        980        990       1000       1010       1020 
CLPLYRVLCD TFPWITPLYE GTLENRRNWQ DLAEKVEMGL TWIDHDTIDK PVEEFAACAD 

      1030       1040       1050       1060       1070       1080 
EEIKDIEFTV TTLNCNQQSQ HGSEDSHTPE HQRSGSRLSM KKTGALGKAV RSKLSKTLYN 

      1090       1100       1110       1120       1130       1140 
SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPQASGSMG RMSASSSTSS AGGQMVDKSK 


KRSKLCALL 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tai18E2 / Tucson 14021-0261.01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000160 Genomic DNA. Translation: EDW97571.1.
RefSeqXP_002097859.1. XM_002097823.1.

3D structure databases

ProteinModelPortalB4PSS5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7245.FBpp0271455.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0272963; FBpp0271455; FBgn0243466.
GeneID6537301.
KEGGdya:Dyak_GE26445.

Organism-specific databases

FlyBaseFBgn0243466. Dyak\GE26445.

Phylogenomic databases

eggNOGNOG270709.
KOK13763.
OrthoDBEOG7RRF69.
PhylomeDBB4PSS5.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMSSF55781. SSF55781. 3 hits.
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDE6_DROYA
AccessionPrimary (citable) accession number: B4PSS5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase