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Protein

Hexokinase

Gene

Hex-t2

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Hex-t2Imported
Synonyms:Dyak\Hex-t2Imported
ORF Names:Dyak_GE23669Imported, GE23669Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0042720. Dyak\Hex-t2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0268679.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 204195Hexokinase_1InterPro annotationAdd
BLAST
Domaini210 – 444235Hexokinase_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026. LUCA.
KOG1369. Eukaryota.
KOiK00844.
OMAiADEMVIN.
OrthoDBiEOG7S21X5.
PhylomeDBiB4PSG6.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PSG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRTSRLFTH SLFGPVLKIL FREGKMPSLV NTEIEAAVKG FLIDQEKMTE
60 70 80 90 100
VVERMTKEIK MGLAKDTHSR AVIKCFVSHV QDLPTGKERG KYLALDLGGS
110 120 130 140 150
TFRVLLVNLL SESDVEIVSK SFNFPVTLMS GSGKALFDFL AECLSEFCHY
160 170 180 190 200
HGLENESLPL GFTFSFPVQQ QGLSKGILVA WTKGFSCEGV VGKNVVTLLQ
210 220 230 240 250
EAIDRRGDMK VNTVAILNDT VGTLMSCAYY HPNCRIGLIV GTGSNACYVE
260 270 280 290 300
KTVNAECFEG YQTSPKPSMI INCEWGAFGD NGVLEFVRTT YDKIVDKVTP
310 320 330 340 350
NPGKQTFEKC ISGMYMGELV RLVVMDMVAR DLMFHGTTSE RMQERWSFKS
360 370 380 390 400
SYISDIESDA PGEYRSCNKV LSELGIVGCQ EPDKEALRFI CEAVSSRSAK
410 420 430 440 450
LCACGLVTII NKMNINEVVI GIDGSVYRFH PKYHDMLQFH MKKLLKPGVK
460 470
FELVVSEDGS GRGAALVAAT AVQGKAKL
Length:478
Mass (Da):52,836
Last modified:January 20, 2016 - v2
Checksum:i6EE02C0BE540D6C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW98628.2.
RefSeqiXP_002098916.1. XM_002098880.1.

Genome annotation databases

EnsemblMetazoaiFBtr0270187; FBpp0268679; FBgn0042720.
GeneIDi6538392.
KEGGidya:Dyak_GE23669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW98628.2.
RefSeqiXP_002098916.1. XM_002098880.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0268679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0270187; FBpp0268679; FBgn0042720.
GeneIDi6538392.
KEGGidya:Dyak_GE23669.

Organism-specific databases

FlyBaseiFBgn0042720. Dyak\Hex-t2.

Phylogenomic databases

eggNOGiCOG5026. LUCA.
KOG1369. Eukaryota.
KOiK00844.
OMAiADEMVIN.
OrthoDBiEOG7S21X5.
PhylomeDBiB4PSG6.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.
  2. "Principles of genome evolution in the Drosophila melanogaster species group."
    Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J., Ashburner M., Bergman C.M.
    PLoS Biol. 5:E152-E152(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.

Entry informationi

Entry nameiB4PSG6_DROYA
AccessioniPrimary (citable) accession number: B4PSG6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: January 20, 2016
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.