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Protein

Hexokinase

Gene

Hex-t2

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Hex-t2Imported
Synonyms:Dyak\Hex-t2Imported
ORF Names:Dyak_GE23669Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0042720. Dyak\Hex-t2.

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0268679.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
KOiK00844.
OMAiYNQDVVA.
OrthoDBiEOG7S21X5.
PhylomeDBiB4PSG6.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PSG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLVNTEIE AAVKGFLIDQ EKMTEVVERM TKEIKMGLAK DTHSRAVIKC
60 70 80 90 100
FVSHVQDLPT GKERGKYLAL DLGGSTFRVL LVNLLSESDV EIVSKSFNFP
110 120 130 140 150
VTLMSGSGKA LFDFLAECLS EFCHYHGLEN ESLPLGFTFS FPVQQQGLSK
160 170 180 190 200
GILVAWTKGF SCEGVVGKNV VTLLQEAIDR RGDMKVNTVA ILNDTVGTLM
210 220 230 240 250
SCAYYHPNCR IGLIVGTGSN ACYVEKTVNA ECFEGYQTSP KPSMIINCEW
260 270 280 290 300
GAFGDNGVLE FVRTTYDKIV DKVTPNPGKQ TFEKCISGMY MGELVRLVVM
310 320 330 340 350
DMVARDLMFH GTTSERMQER WSFKSSYISD IESDAPGEYR SCNKVLSELG
360 370 380 390 400
IVGCQEPDKE ALRFICEAVS SRSAKLCACG LVTIINKMNI NEVVIGIDGS
410 420 430 440 450
VYRFHPKYHD MLQFHMKKLL KPGVKFELVV SEDGSGRGAA LVAATAVQGK

AKL
Length:453
Mass (Da):49,892
Last modified:September 22, 2008 - v1
Checksum:i1B25F2193F177AAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW98628.1.
RefSeqiXP_002098916.1. XM_002098880.1.

Genome annotation databases

EnsemblMetazoaiFBtr0270187; FBpp0268679; FBgn0042720.
GeneIDi6538392.
KEGGidya:Dyak_GE23669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW98628.1.
RefSeqiXP_002098916.1. XM_002098880.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0268679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0270187; FBpp0268679; FBgn0042720.
GeneIDi6538392.
KEGGidya:Dyak_GE23669.

Organism-specific databases

FlyBaseiFBgn0042720. Dyak\Hex-t2.

Phylogenomic databases

eggNOGiCOG5026.
KOiK00844.
OMAiYNQDVVA.
OrthoDBiEOG7S21X5.
PhylomeDBiB4PSG6.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.
  2. "Principles of genome evolution in the Drosophila melanogaster species group."
    Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J., Ashburner M., Bergman C.M.
    PLoS Biol. 5:E152-E152(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiB4PSG6_DROYA
AccessioniPrimary (citable) accession number: B4PSG6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2008
Last sequence update: September 22, 2008
Last modified: March 31, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.