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B4PRE2

- DGKH_DROYA

UniProt

B4PRE2 - DGKH_DROYA

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Protein

Diacylglycerol kinase eta

Gene

GE24946

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GE24946
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3R, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0242040. Dyak\GE24946.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19171917Diacylglycerol kinase etaPRO_0000375991Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHPROSITE-ProRule annotationAdd
BLAST
Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
BLAST
Domaini1854 – 191764SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PRE2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHLKLDTLH VQRSPRGSRR SSRSSGRSSA CSSGSISPVP IIPIISISHD
60 70 80 90 100
GDESESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR
110 120 130 140 150
RRYFPLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT
160 170 180 190 200
RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL
260 270 280 290 300
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC
310 320 330 340 350
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG
360 370 380 390 400
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR
410 420 430 440 450
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG
460 470 480 490 500
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST
510 520 530 540 550
EQEAMLTGMV TSANHHLRFI VETSDTQTLI SSTRNLCDTV DDLVCRISEH
560 570 580 590 600
HKDDEQLAVK CEILRQKLNM LLDALQEEEM GAHSGDDLIA TIRSLIARSI
610 620 630 640 650
PVTPGSSAYL LNPNISIEKT EKDQINTKER RNSRSLRSSE KEALQCRANS
660 670 680 690 700
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG ESSPCTSPLP
710 720 730 740 750
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS
760 770 780 790 800
RRSSGVPEVI QEIEEGANGE TMYRRCRMSL TGGANIDDAG NRLSPCSDGG
810 820 830 840 850
ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFERTYY MTREMDKDKE
860 870 880 890 900
KDKENDKTVE IDKEKDNCVA KEDSIPAERL VHTCNLQVPG VVVTPNTQNV
910 920 930 940 950
YSSASITIID TDAQTTTEQS SSDDLGGEAS DILSAISNEE CSVASEIFDK
960 970 980 990 1000
QDAGQTVGDI IQNMDASNFT HIDSPETSDE TEAMPGESIM DDISSVLGHD
1010 1020 1030 1040 1050
ITYALQDNTL TDDTTTLCSE HAGPPKPPRK KSLSALSRTQ AHPRRRNSSP
1060 1070 1080 1090 1100
PRIARLARMD SDDNPQQFGF ENIVFEIDNR CDDQKMREPP RYCSLAQFVE
1110 1120 1130 1140 1150
GNDIARQSFK QLMLEQQQRD GDNDTEYPEQ QQTPTNKGPN SLATTSEDEL
1160 1170 1180 1190 1200
SAQTAIKIEI HDIDATVRNI NSSMKPNTIL TTSTSPTKKS GHGQDISVVV
1210 1220 1230 1240 1250
RPPTPLRGDS IKPTASLMPV SSGGAMAVSM NCSGMLGVRA MNASEIRRHS
1260 1270 1280 1290 1300
SHAPGLAVRE FDKDKDRRHS GFNPNQLTLD PEHARFLSSS PAASRRISCG
1310 1320 1330 1340 1350
SLFKKKNKKI ATKRSYGLFS VRFFVVAEPD FRLATLALIR PLIPLPNEAL
1360 1370 1380 1390 1400
PNLQSLKGSK SSLFMGSTLF GFDHLASAEK DKDEKGGKDK DKTPTEETNR
1410 1420 1430 1440 1450
KLPIINPLVR LPNWPNLANG GGFISKCLLA NADTLCAAVS PLMDPDETLL
1460 1470 1480 1490 1500
AGYHEKCVMN NYFGIGIDAK ISLDFHNKRE EHPEKCRSRA RNYMWYGVLG
1510 1520 1530 1540 1550
SKQLLQKTCK NLEQRVQLEC DGQRIPLPEL QGIVILNIPS FMGGTNFWGS
1560 1570 1580 1590 1600
STKKDDIFLP PSFDDRVLEV VAVFGSVQMA ASRLINLQHH RIAQCQSVQI
1610 1620 1630 1640 1650
NILGDEEIPI QVDGEAWLQP PGMIRILHKN RVQMLCRNRS LELSLKSWQE
1660 1670 1680 1690 1700
KQRQHSISIQ RDASSTASEH ANSTDEVISE RECYVLLNFI EAVSSLVKWV
1710 1720 1730 1740 1750
KFLIISHPAL QHDLYEVACR ASEALESIHP QGKLLEGPSL RTKLVEVIDS
1760 1770 1780 1790 1800
SRQLYDDACT LLRDRGHSLI LREDLETKLS AALANMEMEL KKCSVQKCID
1810 1820 1830 1840 1850
GKLRAYFNVL APNEESDGRR KSRPFWVRLR SGSTAGQQAF KPPLTNTREA
1860 1870 1880 1890 1900
ASNWSVNEVV TWLETMQLSE YVDSFLKNDI RGKELLTLGR RDLKDLGVVK
1910
VGHVKRILQA IKDLSEN
Length:1,917
Mass (Da):214,006
Last modified:May 26, 2009 - v2
Checksum:iC373CA1DE34FDBA5
GO

Sequence cautioni

The sequence EDW96330.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW96330.1. Sequence problems.
RefSeqiXP_002096618.1. XM_002096582.1.

Genome annotation databases

GeneIDi6536003.
KEGGidya:Dyak_GE24946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW96330.1 . Sequence problems.
RefSeqi XP_002096618.1. XM_002096582.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6536003.
KEGGi dya:Dyak_GE24946.

Organism-specific databases

FlyBasei FBgn0242040. Dyak\GE24946.

Phylogenomic databases

eggNOGi NOG328046.
KOi K00901.
OrthoDBi EOG7DVD9B.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.

Entry informationi

Entry nameiDGKH_DROYA
AccessioniPrimary (citable) accession number: B4PRE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3