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B4PRE2

- DGKH_DROYA

UniProt

B4PRE2 - DGKH_DROYA

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Protein
Diacylglycerol kinase eta
Gene
GE24946
Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) By similarity.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. diacylglycerol kinase activity Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Gene namesi
ORF Names:GE24946
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3R, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0242040. Dyak\GE24946.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19171917Diacylglycerol kinase eta
PRO_0000375991Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PH
Add
BLAST
Domaini350 – 486137DAGKc
Add
BLAST
Domaini1854 – 191764SAM
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BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PRE2-1 [UniParc]FASTAAdd to Basket

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MSHLKLDTLH VQRSPRGSRR SSRSSGRSSA CSSGSISPVP IIPIISISHD     50
GDESESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR 100
RRYFPLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT 150
RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA 200
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC 300
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST 500
EQEAMLTGMV TSANHHLRFI VETSDTQTLI SSTRNLCDTV DDLVCRISEH 550
HKDDEQLAVK CEILRQKLNM LLDALQEEEM GAHSGDDLIA TIRSLIARSI 600
PVTPGSSAYL LNPNISIEKT EKDQINTKER RNSRSLRSSE KEALQCRANS 650
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG ESSPCTSPLP 700
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS 750
RRSSGVPEVI QEIEEGANGE TMYRRCRMSL TGGANIDDAG NRLSPCSDGG 800
ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFERTYY MTREMDKDKE 850
KDKENDKTVE IDKEKDNCVA KEDSIPAERL VHTCNLQVPG VVVTPNTQNV 900
YSSASITIID TDAQTTTEQS SSDDLGGEAS DILSAISNEE CSVASEIFDK 950
QDAGQTVGDI IQNMDASNFT HIDSPETSDE TEAMPGESIM DDISSVLGHD 1000
ITYALQDNTL TDDTTTLCSE HAGPPKPPRK KSLSALSRTQ AHPRRRNSSP 1050
PRIARLARMD SDDNPQQFGF ENIVFEIDNR CDDQKMREPP RYCSLAQFVE 1100
GNDIARQSFK QLMLEQQQRD GDNDTEYPEQ QQTPTNKGPN SLATTSEDEL 1150
SAQTAIKIEI HDIDATVRNI NSSMKPNTIL TTSTSPTKKS GHGQDISVVV 1200
RPPTPLRGDS IKPTASLMPV SSGGAMAVSM NCSGMLGVRA MNASEIRRHS 1250
SHAPGLAVRE FDKDKDRRHS GFNPNQLTLD PEHARFLSSS PAASRRISCG 1300
SLFKKKNKKI ATKRSYGLFS VRFFVVAEPD FRLATLALIR PLIPLPNEAL 1350
PNLQSLKGSK SSLFMGSTLF GFDHLASAEK DKDEKGGKDK DKTPTEETNR 1400
KLPIINPLVR LPNWPNLANG GGFISKCLLA NADTLCAAVS PLMDPDETLL 1450
AGYHEKCVMN NYFGIGIDAK ISLDFHNKRE EHPEKCRSRA RNYMWYGVLG 1500
SKQLLQKTCK NLEQRVQLEC DGQRIPLPEL QGIVILNIPS FMGGTNFWGS 1550
STKKDDIFLP PSFDDRVLEV VAVFGSVQMA ASRLINLQHH RIAQCQSVQI 1600
NILGDEEIPI QVDGEAWLQP PGMIRILHKN RVQMLCRNRS LELSLKSWQE 1650
KQRQHSISIQ RDASSTASEH ANSTDEVISE RECYVLLNFI EAVSSLVKWV 1700
KFLIISHPAL QHDLYEVACR ASEALESIHP QGKLLEGPSL RTKLVEVIDS 1750
SRQLYDDACT LLRDRGHSLI LREDLETKLS AALANMEMEL KKCSVQKCID 1800
GKLRAYFNVL APNEESDGRR KSRPFWVRLR SGSTAGQQAF KPPLTNTREA 1850
ASNWSVNEVV TWLETMQLSE YVDSFLKNDI RGKELLTLGR RDLKDLGVVK 1900
VGHVKRILQA IKDLSEN 1917
Length:1,917
Mass (Da):214,006
Last modified:May 26, 2009 - v2
Checksum:iC373CA1DE34FDBA5
GO

Sequence cautioni

The sequence EDW96330.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW96330.1. Sequence problems.
RefSeqiXP_002096618.1. XM_002096582.1.

Genome annotation databases

GeneIDi6536003.
KEGGidya:Dyak_GE24946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW96330.1 . Sequence problems.
RefSeqi XP_002096618.1. XM_002096582.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6536003.
KEGGi dya:Dyak_GE24946.

Organism-specific databases

FlyBasei FBgn0242040. Dyak\GE24946.

Phylogenomic databases

eggNOGi NOG328046.
KOi K00901.
OrthoDBi EOG7DVD9B.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01.

Entry informationi

Entry nameiDGKH_DROYA
AccessioniPrimary (citable) accession number: B4PRE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi