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Protein

Catalase

Gene

Dyak\GE19975

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.UniRule annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotation

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
Gene namesi
Name:Dyak\GE19975Imported
ORF Names:Dyak_GE19975Imported, GE19975Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0237302. Dyak\GE19975.

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0264985.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0753.
KOiK03781.
OMAiECPRARA.
OrthoDBiEOG7V7660.
PhylomeDBiB4PIY6.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PIY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGRDAASNQ LIDYKNSQTV SPGAITTGNG APIGIKDATQ TVGPRGPILL
60 70 80 90 100
QDVNFLDEMS HFDRERIPER VVHAKGAGAF GYFEVTHDIT QYCAAKVFDK
110 120 130 140 150
VKKRTPLAVR FSTVGGESGS ADTARDPRGF AVKFYTEDGV WDLVGNNTPI
160 170 180 190 200
FFIRDPILFP SFIHTQKRNP QTHLKDPDMF WDFLTLRPES AHQVCFLFGD
210 220 230 240 250
RGTPDGYCHM NGYGSHTFKL INAKGEPIYA KFHLKTDQGI KNLDVKTADQ
260 270 280 290 300
LASSDPDYSI RDLYNRIKTC KFPSWTMYIQ VMTFEQAKKF KYNPFDITKV
310 320 330 340 350
WSHKEYPLIP VGKMVLDRNP KNYFAEVEQI AFSPAHLVPG IEPSPDKMLQ
360 370 380 390 400
GRLFSYSDTH RHRLGPNYLQ IPVNCPYKVK IENFQRDGPM NVTDNQDGAP
410 420 430 440 450
NYFPNSFNGP QECPRARALS SCCPVTGDVY RYSSGDTEDN FGQVTDFWVH
460 470 480 490 500
VLDKCAKKRL VQNIAGHLSG ASQFLQERAV KNFTQVHADF GRMLTEELNL

AKSSKF
Length:506
Mass (Da):57,101
Last modified:September 23, 2008 - v1
Checksum:iCBEAA41E5D17DE82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000159 Genomic DNA. Translation: EDW94577.1.
RefSeqiXP_002094865.1. XM_002094829.1.

Genome annotation databases

EnsemblMetazoaiFBtr0266493; FBpp0264985; FBgn0237302.
GeneIDi6534182.
KEGGidya:Dyak_GE19975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000159 Genomic DNA. Translation: EDW94577.1.
RefSeqiXP_002094865.1. XM_002094829.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0264985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0266493; FBpp0264985; FBgn0237302.
GeneIDi6534182.
KEGGidya:Dyak_GE19975.

Organism-specific databases

FlyBaseiFBgn0237302. Dyak\GE19975.

Phylogenomic databases

eggNOGiCOG0753.
KOiK03781.
OMAiECPRARA.
OrthoDBiEOG7V7660.
PhylomeDBiB4PIY6.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.
  2. "Principles of genome evolution in the Drosophila melanogaster species group."
    Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J., Ashburner M., Bergman C.M.
    PLoS Biol. 5:E152-E152(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiB4PIY6_DROYA
AccessioniPrimary (citable) accession number: B4PIY6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 4, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.