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B4PIW8

- UBP36_DROYA

UniProt

B4PIW8 - UBP36_DROYA

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei182 – 1821NucleophilePROSITE-ProRule annotation
    Active sitei440 – 4401Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GE21508
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002282: Chromosome 3L, UP000002282: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0238765. Dyak\GE21508.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10821082Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei514 – 5141PhosphoserineBy similarity
    Modified residuei516 – 5161PhosphoserineBy similarity
    Modified residuei658 – 6581PhosphothreonineBy similarity
    Modified residuei662 – 6621PhosphothreonineBy similarity
    Modified residuei672 – 6721PhosphoserineBy similarity
    Modified residuei674 – 6741PhosphoserineBy similarity
    Modified residuei747 – 7471PhosphoserineBy similarity
    Modified residuei779 – 7791PhosphoserineBy similarity
    Modified residuei782 – 7821PhosphothreonineBy similarity
    Modified residuei785 – 7851PhosphoserineBy similarity
    Modified residuei823 – 8231PhosphothreonineBy similarity
    Modified residuei841 – 8411PhosphoserineBy similarity
    Modified residuei844 – 8441PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Protein-protein interaction databases

    STRINGi7245.FBpp0266518.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 481309USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    KOiK11855.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB4PIW8.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4PIW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSIDQAKSGE DSNGSLQNHI     50
    VANAKRILMA KIEYEEVPNY HESVLENLKS KYIVIKPGNP GAINGFGGKN 100
    NTGKVVGANG HDNNGARKQA EHPNNQSHHN NHNNHPHPTS NPNELPKPKR 150
    VLYPRENIRI GWKQSERKWQ VGTGMINVGN TCYLNSTLQA LLHIPALANW 200
    LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR PFLIYSKLKQ 250
    ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ 300
    IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADSLED AFEGHFSRER 350
    LEDMGYKCEG CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISL 400
    KPRIDLSKYA ARSPAAQAQP LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG 450
    SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL DLSQAASPAA NRPNGVRLTN 500
    GHSTTPVPAA TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK TAIQFKQHHQ 550
    QSQQNGFQLG TGKFQDTAKP PLVGAHAKGD ANPVPTANGN KSSSTSSNSS 600
    SNHKSINQQQ YLPISSEDED SEDEMTPRPT TAQLPSMPKM TDDHTEKPKS 650
    PVKIQVKTPV KTPLKSLVPY ESASEEEEAP QPNPRKRRSE EDSSESDQES 700
    GQTNGHSKTN GSLTNGSASS SVHVNNSKQK TDAIDEIFKS LKKSADSDDD 750
    DDEEESSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK SKTGIWKVTR 800
    NDEVDDIDDD DDEEDEAPAK IQTPSKTHRN PFSSTKPSTE SPATPGAKRQ 850
    KLLNGSAVKS HQQPRVGNGY QSEATSNGST INELLKQSHR GYGSSVLSWN 900
    GKPAELEKEP FELVCAKRIA GHGSVDGSDI VESSVAVNAS SGSDSNDVVV 950
    IALLVDAREQ RQRDLDDDEE NEMDRGRQRK VKSSGSAKAN NASNSTPGYN 1000
    PFQEYEGQKR WNKNGGGGGG FPRFYNQNFR QNFQQRNKFK FNRFGGPGSA 1050
    KFQQQRALQR HLAAGGGFSR RQPSAQQQQQ QS 1082
    Length:1,082
    Mass (Da):118,583
    Last modified:September 23, 2008 - v1
    Checksum:i047FCB6AD4F1BD81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000159 Genomic DNA. Translation: EDW93538.1.
    RefSeqiXP_002093826.1. XM_002093790.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0268026; FBpp0266518; FBgn0238765.
    GeneIDi6533100.
    KEGGidya:Dyak_GE21508.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000159 Genomic DNA. Translation: EDW93538.1 .
    RefSeqi XP_002093826.1. XM_002093790.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7245.FBpp0266518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0268026 ; FBpp0266518 ; FBgn0238765 .
    GeneIDi 6533100.
    KEGGi dya:Dyak_GE21508.

    Organism-specific databases

    FlyBasei FBgn0238765. Dyak\GE21508.

    Phylogenomic databases

    eggNOGi COG5533.
    KOi K11855.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B4PIW8.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tai18E2 / Tucson 14021-0261.01.

    Entry informationi

    Entry nameiUBP36_DROYA
    AccessioniPrimary (citable) accession number: B4PIW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3