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B4PIW8 (UBP36_DROYA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GE21508
OrganismDrosophila yakuba (Fruit fly) [Complete proteome]
Taxonomic identifier7245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1082 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10821082Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378505

Regions

Domain173 – 481309USP

Sites

Active site1821Nucleophile By similarity
Active site4401Proton acceptor By similarity

Amino acid modifications

Modified residue5141Phosphoserine By similarity
Modified residue5161Phosphoserine By similarity
Modified residue6581Phosphothreonine By similarity
Modified residue6621Phosphothreonine By similarity
Modified residue6721Phosphoserine By similarity
Modified residue6741Phosphoserine By similarity
Modified residue7471Phosphoserine By similarity
Modified residue7791Phosphoserine By similarity
Modified residue7821Phosphothreonine By similarity
Modified residue7851Phosphoserine By similarity
Modified residue8231Phosphothreonine By similarity
Modified residue8411Phosphoserine By similarity
Modified residue8441Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4PIW8 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 047FCB6AD4F1BD81

FASTA1,082118,583
        10         20         30         40         50         60 
MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSIDQAKSGE DSNGSLQNHI VANAKRILMA 

        70         80         90        100        110        120 
KIEYEEVPNY HESVLENLKS KYIVIKPGNP GAINGFGGKN NTGKVVGANG HDNNGARKQA 

       130        140        150        160        170        180 
EHPNNQSHHN NHNNHPHPTS NPNELPKPKR VLYPRENIRI GWKQSERKWQ VGTGMINVGN 

       190        200        210        220        230        240 
TCYLNSTLQA LLHIPALANW LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR 

       250        260        270        280        290        300 
PFLIYSKLKQ ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ 

       310        320        330        340        350        360 
IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADSLED AFEGHFSRER LEDMGYKCEG 

       370        380        390        400        410        420 
CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISL KPRIDLSKYA ARSPAAQAQP 

       430        440        450        460        470        480 
LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL 

       490        500        510        520        530        540 
DLSQAASPAA NRPNGVRLTN GHSTTPVPAA TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK 

       550        560        570        580        590        600 
TAIQFKQHHQ QSQQNGFQLG TGKFQDTAKP PLVGAHAKGD ANPVPTANGN KSSSTSSNSS 

       610        620        630        640        650        660 
SNHKSINQQQ YLPISSEDED SEDEMTPRPT TAQLPSMPKM TDDHTEKPKS PVKIQVKTPV 

       670        680        690        700        710        720 
KTPLKSLVPY ESASEEEEAP QPNPRKRRSE EDSSESDQES GQTNGHSKTN GSLTNGSASS 

       730        740        750        760        770        780 
SVHVNNSKQK TDAIDEIFKS LKKSADSDDD DDEEESSIQL TNGWHPQKQS QSQSKAPPSP 

       790        800        810        820        830        840 
KTPPSPAVIK SKTGIWKVTR NDEVDDIDDD DDEEDEAPAK IQTPSKTHRN PFSSTKPSTE 

       850        860        870        880        890        900 
SPATPGAKRQ KLLNGSAVKS HQQPRVGNGY QSEATSNGST INELLKQSHR GYGSSVLSWN 

       910        920        930        940        950        960 
GKPAELEKEP FELVCAKRIA GHGSVDGSDI VESSVAVNAS SGSDSNDVVV IALLVDAREQ 

       970        980        990       1000       1010       1020 
RQRDLDDDEE NEMDRGRQRK VKSSGSAKAN NASNSTPGYN PFQEYEGQKR WNKNGGGGGG 

      1030       1040       1050       1060       1070       1080 
FPRFYNQNFR QNFQQRNKFK FNRFGGPGSA KFQQQRALQR HLAAGGGFSR RQPSAQQQQQ 


QS 

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tai18E2 / Tucson 14021-0261.01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000159 Genomic DNA. Translation: EDW93538.1.
RefSeqXP_002093826.1. XM_002093790.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7245.FBpp0266518.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0268026; FBpp0266518; FBgn0238765.
GeneID6533100.
KEGGdya:Dyak_GE21508.

Organism-specific databases

FlyBaseFBgn0238765. Dyak\GE21508.

Phylogenomic databases

eggNOGCOG5533.
KOK11855.
OrthoDBEOG7XDBF6.
PhylomeDBB4PIW8.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROYA
AccessionPrimary (citable) accession number: B4PIW8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase