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B4PIW8

- UBP36_DROYA

UniProt

B4PIW8 - UBP36_DROYA

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Protein
Ubiquitin carboxyl-terminal hydrolase 36
Gene
Usp36, scny, GE21508
Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Nucleophile By similarity
Active sitei440 – 4401Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GE21508
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3L, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0238765. Dyak\GE21508.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10821082Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei514 – 5141Phosphoserine By similarity
Modified residuei516 – 5161Phosphoserine By similarity
Modified residuei658 – 6581Phosphothreonine By similarity
Modified residuei662 – 6621Phosphothreonine By similarity
Modified residuei672 – 6721Phosphoserine By similarity
Modified residuei674 – 6741Phosphoserine By similarity
Modified residuei747 – 7471Phosphoserine By similarity
Modified residuei779 – 7791Phosphoserine By similarity
Modified residuei782 – 7821Phosphothreonine By similarity
Modified residuei785 – 7851Phosphoserine By similarity
Modified residuei823 – 8231Phosphothreonine By similarity
Modified residuei841 – 8411Phosphoserine By similarity
Modified residuei844 – 8441Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Protein-protein interaction databases

STRINGi7245.FBpp0266518.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 481309USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4PIW8.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PIW8-1 [UniParc]FASTAAdd to Basket

« Hide

MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSIDQAKSGE DSNGSLQNHI     50
VANAKRILMA KIEYEEVPNY HESVLENLKS KYIVIKPGNP GAINGFGGKN 100
NTGKVVGANG HDNNGARKQA EHPNNQSHHN NHNNHPHPTS NPNELPKPKR 150
VLYPRENIRI GWKQSERKWQ VGTGMINVGN TCYLNSTLQA LLHIPALANW 200
LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR PFLIYSKLKQ 250
ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ 300
IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADSLED AFEGHFSRER 350
LEDMGYKCEG CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISL 400
KPRIDLSKYA ARSPAAQAQP LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG 450
SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL DLSQAASPAA NRPNGVRLTN 500
GHSTTPVPAA TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK TAIQFKQHHQ 550
QSQQNGFQLG TGKFQDTAKP PLVGAHAKGD ANPVPTANGN KSSSTSSNSS 600
SNHKSINQQQ YLPISSEDED SEDEMTPRPT TAQLPSMPKM TDDHTEKPKS 650
PVKIQVKTPV KTPLKSLVPY ESASEEEEAP QPNPRKRRSE EDSSESDQES 700
GQTNGHSKTN GSLTNGSASS SVHVNNSKQK TDAIDEIFKS LKKSADSDDD 750
DDEEESSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK SKTGIWKVTR 800
NDEVDDIDDD DDEEDEAPAK IQTPSKTHRN PFSSTKPSTE SPATPGAKRQ 850
KLLNGSAVKS HQQPRVGNGY QSEATSNGST INELLKQSHR GYGSSVLSWN 900
GKPAELEKEP FELVCAKRIA GHGSVDGSDI VESSVAVNAS SGSDSNDVVV 950
IALLVDAREQ RQRDLDDDEE NEMDRGRQRK VKSSGSAKAN NASNSTPGYN 1000
PFQEYEGQKR WNKNGGGGGG FPRFYNQNFR QNFQQRNKFK FNRFGGPGSA 1050
KFQQQRALQR HLAAGGGFSR RQPSAQQQQQ QS 1082
Length:1,082
Mass (Da):118,583
Last modified:September 23, 2008 - v1
Checksum:i047FCB6AD4F1BD81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000159 Genomic DNA. Translation: EDW93538.1.
RefSeqiXP_002093826.1. XM_002093790.1.

Genome annotation databases

EnsemblMetazoaiFBtr0268026; FBpp0266518; FBgn0238765.
GeneIDi6533100.
KEGGidya:Dyak_GE21508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000159 Genomic DNA. Translation: EDW93538.1 .
RefSeqi XP_002093826.1. XM_002093790.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7245.FBpp0266518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0268026 ; FBpp0266518 ; FBgn0238765 .
GeneIDi 6533100.
KEGGi dya:Dyak_GE21508.

Organism-specific databases

FlyBasei FBgn0238765. Dyak\GE21508.

Phylogenomic databases

eggNOGi COG5533.
KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4PIW8.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01.

Entry informationi

Entry nameiUBP36_DROYA
AccessioniPrimary (citable) accession number: B4PIW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi