Ubiquitin carboxyl-terminal hydrolase 36 - Drosophila yakuba (Fruit fly)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36

Gene names

Name:	Usp36
Synonyms:	scny
ORF Names:	GE21508

Organism

Drosophila yakuba (Fruit fly) [Complete proteome]

Taxonomic identifier

7245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length	1082 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Interacts with atms/PAF1, but not with CycT By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	germ-line stem cell maintenance Inferred from sequence or structural similarity. Source: UniProtKB protein deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB somatic stem cell maintenance Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1082

1082

Ubiquitin carboxyl-terminal hydrolase 36

PRO_0000378505

Sites

Active site

182

1

Nucleophile By similarity

Active site

440

1

Proton acceptor By similarity

Amino acid modifications

Modified residue

514

1

Phosphoserine By similarity

Modified residue

516

1

Phosphoserine By similarity

Modified residue

658

1

Phosphothreonine By similarity

Modified residue

662

1

Phosphothreonine By similarity

Modified residue

672

1

Phosphoserine By similarity

Modified residue

674

1

Phosphoserine By similarity

Modified residue

747

1

Phosphoserine By similarity

Modified residue

779

1

Phosphoserine By similarity

Modified residue

782

1

Phosphothreonine By similarity

Modified residue

785

1

Phosphoserine By similarity

Modified residue

823

1

Phosphothreonine By similarity

Modified residue

841

1

Phosphoserine By similarity

Modified residue

844

1

Phosphothreonine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

B4PIW8 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 047FCB6AD4F1BD81
Show »

FASTA

1,082

118,583

        10         20         30         40         50         60 
MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSIDQAKSGE DSNGSLQNHI VANAKRILMA 

        70         80         90        100        110        120 
KIEYEEVPNY HESVLENLKS KYIVIKPGNP GAINGFGGKN NTGKVVGANG HDNNGARKQA 

       130        140        150        160        170        180 
EHPNNQSHHN NHNNHPHPTS NPNELPKPKR VLYPRENIRI GWKQSERKWQ VGTGMINVGN 

       190        200        210        220        230        240 
TCYLNSTLQA LLHIPALANW LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR 

       250        260        270        280        290        300 
PFLIYSKLKQ ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ 

       310        320        330        340        350        360 
IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADSLED AFEGHFSRER LEDMGYKCEG 

       370        380        390        400        410        420 
CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISL KPRIDLSKYA ARSPAAQAQP 

       430        440        450        460        470        480 
LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL 

       490        500        510        520        530        540 
DLSQAASPAA NRPNGVRLTN GHSTTPVPAA TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK 

       550        560        570        580        590        600 
TAIQFKQHHQ QSQQNGFQLG TGKFQDTAKP PLVGAHAKGD ANPVPTANGN KSSSTSSNSS 

       610        620        630        640        650        660 
SNHKSINQQQ YLPISSEDED SEDEMTPRPT TAQLPSMPKM TDDHTEKPKS PVKIQVKTPV 

       670        680        690        700        710        720 
KTPLKSLVPY ESASEEEEAP QPNPRKRRSE EDSSESDQES GQTNGHSKTN GSLTNGSASS 

       730        740        750        760        770        780 
SVHVNNSKQK TDAIDEIFKS LKKSADSDDD DDEEESSIQL TNGWHPQKQS QSQSKAPPSP 

       790        800        810        820        830        840 
KTPPSPAVIK SKTGIWKVTR NDEVDDIDDD DDEEDEAPAK IQTPSKTHRN PFSSTKPSTE 

       850        860        870        880        890        900 
SPATPGAKRQ KLLNGSAVKS HQQPRVGNGY QSEATSNGST INELLKQSHR GYGSSVLSWN 

       910        920        930        940        950        960 
GKPAELEKEP FELVCAKRIA GHGSVDGSDI VESSVAVNAS SGSDSNDVVV IALLVDAREQ 

       970        980        990       1000       1010       1020 
RQRDLDDDEE NEMDRGRQRK VKSSGSAKAN NASNSTPGYN PFQEYEGQKR WNKNGGGGGG 

      1030       1040       1050       1060       1070       1080 
FPRFYNQNFR QNFQQRNKFK FNRFGGPGSA KFQQQRALQR HLAAGGGFSR RQPSAQQQQQ 


QS

« Hide

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tai18E2 / Tucson 14021-0261.01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CM000159 Genomic DNA. Translation: EDW93538.1.
RefSeq	XP_002093826.1. XM_002093790.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	7245.FBpp0266518.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0268026; FBpp0266518; FBgn0238765.
GeneID	6533100.
KEGG	dya:Dyak_GE21508.
Organism-specific databases
FlyBase	FBgn0238765. Dyak\GE21508.
Phylogenomic databases
eggNOG	COG5533.
KO	K11855.
OrthoDB	EOG4WM38P.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBP36_DROYA

Accession

Primary (citable) accession number: B4PIW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 7, 2009
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents