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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821NucleophilePROSITE-ProRule annotation
Active sitei440 – 4401Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GE21508
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282 Componentsi: Chromosome 3L, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0238765. Dyak\GE21508.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10821082Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei514 – 5141PhosphoserineBy similarity
Modified residuei516 – 5161PhosphoserineBy similarity
Modified residuei658 – 6581PhosphothreonineBy similarity
Modified residuei662 – 6621PhosphothreonineBy similarity
Modified residuei672 – 6721PhosphoserineBy similarity
Modified residuei674 – 6741PhosphoserineBy similarity
Modified residuei747 – 7471PhosphoserineBy similarity
Modified residuei779 – 7791PhosphoserineBy similarity
Modified residuei782 – 7821PhosphothreonineBy similarity
Modified residuei785 – 7851PhosphoserineBy similarity
Modified residuei823 – 8231PhosphothreonineBy similarity
Modified residuei841 – 8411PhosphoserineBy similarity
Modified residuei844 – 8441PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0266518.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 481309USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
KOiK11855.
OMAiNEMDRGR.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4PIW8.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PIW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSIDQAKSGE DSNGSLQNHI
60 70 80 90 100
VANAKRILMA KIEYEEVPNY HESVLENLKS KYIVIKPGNP GAINGFGGKN
110 120 130 140 150
NTGKVVGANG HDNNGARKQA EHPNNQSHHN NHNNHPHPTS NPNELPKPKR
160 170 180 190 200
VLYPRENIRI GWKQSERKWQ VGTGMINVGN TCYLNSTLQA LLHIPALANW
210 220 230 240 250
LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR PFLIYSKLKQ
260 270 280 290 300
ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ
310 320 330 340 350
IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADSLED AFEGHFSRER
360 370 380 390 400
LEDMGYKCEG CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISL
410 420 430 440 450
KPRIDLSKYA ARSPAAQAQP LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG
460 470 480 490 500
SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL DLSQAASPAA NRPNGVRLTN
510 520 530 540 550
GHSTTPVPAA TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK TAIQFKQHHQ
560 570 580 590 600
QSQQNGFQLG TGKFQDTAKP PLVGAHAKGD ANPVPTANGN KSSSTSSNSS
610 620 630 640 650
SNHKSINQQQ YLPISSEDED SEDEMTPRPT TAQLPSMPKM TDDHTEKPKS
660 670 680 690 700
PVKIQVKTPV KTPLKSLVPY ESASEEEEAP QPNPRKRRSE EDSSESDQES
710 720 730 740 750
GQTNGHSKTN GSLTNGSASS SVHVNNSKQK TDAIDEIFKS LKKSADSDDD
760 770 780 790 800
DDEEESSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK SKTGIWKVTR
810 820 830 840 850
NDEVDDIDDD DDEEDEAPAK IQTPSKTHRN PFSSTKPSTE SPATPGAKRQ
860 870 880 890 900
KLLNGSAVKS HQQPRVGNGY QSEATSNGST INELLKQSHR GYGSSVLSWN
910 920 930 940 950
GKPAELEKEP FELVCAKRIA GHGSVDGSDI VESSVAVNAS SGSDSNDVVV
960 970 980 990 1000
IALLVDAREQ RQRDLDDDEE NEMDRGRQRK VKSSGSAKAN NASNSTPGYN
1010 1020 1030 1040 1050
PFQEYEGQKR WNKNGGGGGG FPRFYNQNFR QNFQQRNKFK FNRFGGPGSA
1060 1070 1080
KFQQQRALQR HLAAGGGFSR RQPSAQQQQQ QS
Length:1,082
Mass (Da):118,583
Last modified:September 23, 2008 - v1
Checksum:i047FCB6AD4F1BD81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000159 Genomic DNA. Translation: EDW93538.1.
RefSeqiXP_002093826.1. XM_002093790.1.

Genome annotation databases

EnsemblMetazoaiFBtr0268026; FBpp0266518; FBgn0238765.
GeneIDi6533100.
KEGGidya:Dyak_GE21508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000159 Genomic DNA. Translation: EDW93538.1.
RefSeqiXP_002093826.1. XM_002093790.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0266518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0268026; FBpp0266518; FBgn0238765.
GeneIDi6533100.
KEGGidya:Dyak_GE21508.

Organism-specific databases

FlyBaseiFBgn0238765. Dyak\GE21508.

Phylogenomic databases

eggNOGiCOG5533.
KOiK11855.
OMAiNEMDRGR.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4PIW8.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01.

Entry informationi

Entry nameiUBP36_DROYA
AccessioniPrimary (citable) accession number: B4PIW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: March 4, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.