Reviewed, UniProtKB/Swiss-Prot B4PAR6 (KAD2_DROYA)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 2, mitochondrial
      Short name=AK 2
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 2

Gene names

Name:	Adk2
ORF Names:	GE14359

Organism

Drosophila yakuba (Fruit fly)

Taxonomic identifier

7245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Disulfide bond Phosphoprotein
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Adenylate kinase 2, mitochondrial		PRO_0000365713
Regions
	Nucleotide binding	25 – 33	9	ATP By similarity
	Nucleotide binding	48 – 77	30	AMP By similarity
Sites
	Binding site	49	1	AMP By similarity
Amino acid modifications
	Modified residue	48	1	Phosphoserine By similarity
	Disulfide bond	45 ↔ 95		By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4PAR6-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: A46954CA5D6661E5	FASTA	240	26,513
	10 20 30 40 50 60 MAPNAAVPVE RYEPQNIGIN AILLGPPGSG KGTQAPLLKE KFCVCHLSTG DMLRAEISSG 70 80 90 100 110 120 SKLGAELKKV MDAGKLVSDE LVVDMIDSNL DKPECKNGFL LDGFPRTVVQ AEKLDTLLDK 130 140 150 160 170 180 RKTNLDAVIE FAIDDSLLVR RITGRLIHQA SGRSYHEEFA PPKKPMTDDV TGEPLIRRSD 190 200 210 220 230 240 DNAEALKKRL EAYHKQTKPL VDYYGLRGLH FKVDAAKKSS DVFSTIDSIF QNKRPAQIQL

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tai18E2 / Tucson 14021-0261.01.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CM000158 Genomic DNA. Translation: EDW92456.1.
RefSeq	XP_002092744.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6531958.
KEGG	dya:Dyak_GE14359.
Organism-specific databases
FlyBase	FBgn0231971. Dyak\GE14359.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD2_DROYA

Accession

Primary (citable) accession number: B4PAR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 23, 2008
Last modified:	June 16, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project