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Protein

DNA ligase

Gene

Dyak\GE14336

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dyak\GE14336Imported
ORF Names:Dyak_GE14336Imported, GE14336Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0231950. Dyak\GE14336.

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0259346.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.
OMAiLACYDEQ.
OrthoDBiEOG7RFTGN.
PhylomeDBiB4PA92.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4PA92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKSITSFFK KQSDANDSAS PPKKVPKIDA KTELPDEPLI KSESASPETK
60 70 80 90 100
AKVEPMSVDS EEKTSPVKNV KTEPKDVEDK TTDKKVTTIG LNSTSATKED
110 120 130 140 150
MENYDPSADS YHPLKNAYWK DKKVTPYLAL ARTFQVIEET KGRLKMIDTL
160 170 180 190 200
SNFFCSVMLV SPDDLVPSVY LSINQLAPAY EGLELGVAET TLMKAICKAT
210 220 230 240 250
GRNLAHIKSQ THLIGDLGIV AEQSRVSQRM MFQPAPLNVR DVFRKLREIA
260 270 280 290 300
KISGQSKMDQ VYNMFVACRS SEARFFIRSL IGKLRIGIAE QSLLTALAVG
310 320 330 340 350
LVKKNHIDDC KASKVPEVYK DEIAETTLLL KTAYCQCPNY DIIIPAILKY
360 370 380 390 400
DIKELQERCP MHPGMPLRPM LAQPTKGVHE VFERFGGMQI TCEWKYDGER
410 420 430 440 450
AQIHRNEKGE ISIFSRNSEN NTAKYPDLIA RSAGLLKGDI KSYIIDSEIV
460 470 480 490 500
AWDVERKQIL PFQVLSTRKR KNVDIEEIKV QVCVYIFDLL YINGTALVTK
510 520 530 540 550
NLSERRKLLL EHFQEVEGEW KFATALDTND IDEVQQFLEE SIKGNCEGLM
560 570 580 590 600
VKTLDEEATY EIAKRSRNWL KLKKDYLSNV GDSLDLVVIG GYKGKGRRTG
610 620 630 640 650
TYGGFLLACY DTENEEYQSI CKIGTGFTDE DLQTHSEFLG KHVTSTAKSY
660 670 680 690 700
YRYDPSLEPD HWFEPVQVWE VKCADLSLSP IHRAAIGIVD GERGISLRFP
710 720 730 740
RFIRIRDDKN SENATDANQV AHMYQSQDQV KNNQKSSTQM EMEDEFY
Length:747
Mass (Da):84,685
Last modified:September 23, 2008 - v1
Checksum:iE04C6CA0EA0FB6EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA. Translation: EDW92418.1.
RefSeqiXP_002092706.1. XM_002092670.1.

Genome annotation databases

EnsemblMetazoaiFBtr0260854; FBpp0259346; FBgn0231950.
GeneIDi6531920.
KEGGidya:Dyak_GE14336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA. Translation: EDW92418.1.
RefSeqiXP_002092706.1. XM_002092670.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0259346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0260854; FBpp0259346; FBgn0231950.
GeneIDi6531920.
KEGGidya:Dyak_GE14336.

Organism-specific databases

FlyBaseiFBgn0231950. Dyak\GE14336.

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.
OMAiLACYDEQ.
OrthoDBiEOG7RFTGN.
PhylomeDBiB4PA92.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.
  2. "Principles of genome evolution in the Drosophila melanogaster species group."
    Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J., Ashburner M., Bergman C.M.
    PLoS Biol. 5:E152-E152(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiB4PA92_DROYA
AccessioniPrimary (citable) accession number: B4PA92
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.