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Protein

Hexokinase

Gene

Hex-C

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Hex-CImported
Synonyms:Dyak\Hex-CImported
ORF Names:Dyak_GE12255Imported, GE12255Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0020949. Dyak\Hex-C.

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0257265.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
KOiK00844.
OMAiKGHHDAT.
OrthoDBiEOG7S21X5.
PhylomeDBiB4P7U8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4P7U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDAEVRELM QPFVLSDYQV QEVYSRFCLE VARGLKRSTH PQANVKCFPT
60 70 80 90 100
YVQDLPTGDE MGKYLALDLG GTNFRVLLVS LKGHHDATVD SQIYAVPKDL
110 120 130 140 150
MVGSGVQLFD HIAGCLAKFV EKHDMKTAYL PLGFTFSFPC VQLGLKEGIL
160 170 180 190 200
VRWTKGFDCA GVEGEDVGRM LHEAIQRRGD ADIAVVAILN DTTGTLMSCA
210 220 230 240 250
HRNADCRVGV IVGTGCNACY VEDVENVDLL RADFKKSKRS VIVNAEWGAF
260 270 280 290 300
GEGGQLDFVR TEYDREVDEK SINRAEQLFE KMTAGMYLGN LVRLVLLRAL
310 320 330 340 350
ERKLIFKQSS RRPEFAGVLQ RNEEVFETRY ISEIEDDSFP EFASTRKIVK
360 370 380 390 400
NLFGLEKASV EDCQTLRYIC ECVAKRAATL VAIGVSGLVN RTSNRRVIVG
410 420 430 440 450
MDGSVYRYHP KFDAYMRQTL QKLVKADKEW DIMLSEDGSG RGAALVAAVA

SKSK
Length:454
Mass (Da):50,667
Last modified:September 23, 2008 - v1
Checksum:i3DA8D4D8585FAC02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA. Translation: EDW91124.1.
RefSeqiXP_002091412.1. XM_002091376.1.

Genome annotation databases

EnsemblMetazoaiFBtr0258773; FBpp0257265; FBgn0020949.
GeneIDi6530497.
KEGGidya:Dyak_GE12255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA. Translation: EDW91124.1.
RefSeqiXP_002091412.1. XM_002091376.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0257265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0258773; FBpp0257265; FBgn0020949.
GeneIDi6530497.
KEGGidya:Dyak_GE12255.

Organism-specific databases

FlyBaseiFBgn0020949. Dyak\Hex-C.

Phylogenomic databases

eggNOGiCOG5026.
KOiK00844.
OMAiKGHHDAT.
OrthoDBiEOG7S21X5.
PhylomeDBiB4P7U8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01Imported.
  2. "Principles of genome evolution in the Drosophila melanogaster species group."
    Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J., Ashburner M., Bergman C.M.
    PLoS Biol. 5:E152-E152(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiB4P7U8_DROYA
AccessioniPrimary (citable) accession number: B4P7U8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.