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Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131NucleophileBy similarity1
Active sitei213Proton donorBy similarity1
Sitei228Important for enzyme activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:GE14091
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componentsi: Chromosome 2R, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0231717. Dyak\GE14091.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003958351 – 471Ubiquitin carboxyl-terminal hydrolase calypsoAdd BLAST471

Expressioni

Gene expression databases

BgeeiFBgn0231717.

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

Protein-protein interaction databases

STRINGi7245.FBpp0259101.

Structurei

3D structure databases

SMRiB4P6P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2778. Eukaryota.
ENOG410XP0P. LUCA.
KOiK08588.
OMAiHAMPQAR.
OrthoDBiEOG091G08R7.
PhylomeDBiB4P6P6.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiView protein in InterPro
IPR001578. Peptidase_C12_UCH.
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiView protein in Pfam
PF01088. Peptidase_C12. 1 hit.
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B4P6P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAGGGSGS QAAGAAGVNS SLSHNALLST ASGATTMPMA QLADGWLELE
60 70 80 90 100
SDPGLFTLLL KDFGCHDVQV EEVYDLQKPI ESPYGFIFLF RWIEERRARR
110 120 130 140 150
KIVETTAEIF VKDEEAISSI FFAQQVVPNS CATHALLSVL LNCNENNLQL
160 170 180 190 200
GDTLSRLKAH TKGMSPENKG LAIGNTPELA CAHNSHAMPQ ARRRLERTGA
210 220 230 240 250
GVSSCRFTGE AFHFVSFVPI NGQLFELDGL KPYPMNHGGW EDSEDWTDKF
260 270 280 290 300
RRVMAERLGI ATGEQDIRFN LMAVVPDRRI AITHKLKMLR TNQAIVSGTL
310 320 330 340 350
QKLLKADEQG ESGNGDSQRP DTPTTLLEPS AFTARDLQSL LKNLDTEIAI
360 370 380 390 400
NEQHLADEND RRHMFKVDAS RRTHNYDKFI CTFLSMLAHQ GVLGELVSQH
410 420 430 440 450
LLPSKKVSGQ GAANRISKQS TTASAGGSTT GATASTPKTQ QQQAAAAKNG
460 470
KSPSKTPGRR RKGRNKCRKR K
Length:471
Mass (Da):51,482
Last modified:September 23, 2008 - v1
Checksum:i2E576237C4F8ABCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA. Translation: EDW91973.1.
RefSeqiXP_002092261.1. XM_002092225.2.

Genome annotation databases

EnsemblMetazoaiFBtr0260609; FBpp0259101; FBgn0231717.
GeneIDi6531462.
KEGGidya:Dyak_GE14091.

Similar proteinsi

Entry informationi

Entry nameiCALYP_DROYA
AccessioniPrimary (citable) accession number: B4P6P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: August 30, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families