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B4P6P6

- CALYP_DROYA

UniProt

B4P6P6 - CALYP_DROYA

Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311NucleophileBy similarity
    Active sitei213 – 2131Proton donorBy similarity
    Sitei228 – 2281Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. chromatin silencing Source: UniProtKB
    2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.A09.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
    Alternative name(s):
    BAP1 homolog
    Gene namesi
    Name:calypso
    ORF Names:GE14091
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002282: Chromosome 2R, UP000002282: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0231717. Dyak\GE14091.

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes to PcG response elements (PREs).By similarity

    GO - Cellular componenti

    1. nuclear chromatin Source: UniProtKB
    2. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395835Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

    Protein-protein interaction databases

    STRINGi7245.FBpp0259101.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG249036.
    KOiK08588.
    OrthoDBiEOG7GN2M2.
    PhylomeDBiB4P6P6.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    B4P6P6-1 [UniParc]FASTAAdd to Basket

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    MNAAGGGSGS QAAGAAGVNS SLSHNALLST ASGATTMPMA QLADGWLELE    50
    SDPGLFTLLL KDFGCHDVQV EEVYDLQKPI ESPYGFIFLF RWIEERRARR 100
    KIVETTAEIF VKDEEAISSI FFAQQVVPNS CATHALLSVL LNCNENNLQL 150
    GDTLSRLKAH TKGMSPENKG LAIGNTPELA CAHNSHAMPQ ARRRLERTGA 200
    GVSSCRFTGE AFHFVSFVPI NGQLFELDGL KPYPMNHGGW EDSEDWTDKF 250
    RRVMAERLGI ATGEQDIRFN LMAVVPDRRI AITHKLKMLR TNQAIVSGTL 300
    QKLLKADEQG ESGNGDSQRP DTPTTLLEPS AFTARDLQSL LKNLDTEIAI 350
    NEQHLADEND RRHMFKVDAS RRTHNYDKFI CTFLSMLAHQ GVLGELVSQH 400
    LLPSKKVSGQ GAANRISKQS TTASAGGSTT GATASTPKTQ QQQAAAAKNG 450
    KSPSKTPGRR RKGRNKCRKR K 471
    Length:471
    Mass (Da):51,482
    Last modified:September 23, 2008 - v1
    Checksum:i2E576237C4F8ABCF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000158 Genomic DNA. Translation: EDW91973.1.
    RefSeqiXP_002092261.1. XM_002092225.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0260609; FBpp0259101; FBgn0231717.
    GeneIDi6531462.
    KEGGidya:Dyak_GE14091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000158 Genomic DNA. Translation: EDW91973.1 .
    RefSeqi XP_002092261.1. XM_002092225.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7245.FBpp0259101.

    Protein family/group databases

    MEROPSi C12.A09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0260609 ; FBpp0259101 ; FBgn0231717 .
    GeneIDi 6531462.
    KEGGi dya:Dyak_GE14091.

    Organism-specific databases

    FlyBasei FBgn0231717. Dyak\GE14091.

    Phylogenomic databases

    eggNOGi NOG249036.
    KOi K08588.
    OrthoDBi EOG7GN2M2.
    PhylomeDBi B4P6P6.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tai18E2 / Tucson 14021-0261.01.

    Entry informationi

    Entry nameiCALYP_DROYA
    AccessioniPrimary (citable) accession number: B4P6P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3