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Protein

Superoxide dismutase [Cu-Zn]

Gene

Dyak\GE13524

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Dyak\GE13524Imported
ORF Names:Dyak_GE13524Imported, GE13524Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0231191 Dyak\GE13524

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500645873819 – 217Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST199

Expressioni

Gene expression databases

BgeeiFBgn0231191

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0258534

Structurei

3D structure databases

SMRiB4P649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 178Sod_CuInterPro annotationAdd BLAST139

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
KOiK04565
OrthoDBiEOG091G0OG2

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

B4P649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQYLVVSLA LCATICSAAQ TRNMPIQAIA YLIGPVQSDN TQVKGNVTFT
60 70 80 90 100
QNDCGQNVHV RVQLEGLKEG KHGFHIHEKG DLTNGCLSMG AHYNPDKVDH
110 120 130 140 150
GGPDHEVRHV GDLGNLEVNS SGIIDVTYTD PVITLTGKMA VIGRGVVVHE
160 170 180 190 200
LEDDLGLGNH TDSKKTGNAG GRIACGVIGI NSDVDEWPCR DGGAGALRYS
210
FSILTVIVAL IMARSLD
Length:217
Mass (Da):23,070
Last modified:January 20, 2016 - v2
Checksum:iC970AD055AC61DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA Translation: EDW90924.2
RefSeqiXP_002091212.2, XM_002091176.2

Genome annotation databases

EnsemblMetazoaiFBtr0260042; FBpp0258534; FBgn0231191
GeneIDi6530284
KEGGidya:Dyak_GE13524

Similar proteinsi

Entry informationi

Entry nameiB4P649_DROYA
AccessioniPrimary (citable) accession number: B4P649
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: June 20, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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