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Protein

Superoxide dismutase [Cu-Zn]

Gene

Dyak\GE13524

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Dyak\GE13524Imported
ORF Names:Dyak_GE13524Imported, GE13524Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0231191. Dyak\GE13524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500645873819 – 217Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST199

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0258534.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 178Sod_CuInterPro annotationAdd BLAST139

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
KOiK04565.
OrthoDBiEOG091G0OG2.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4P649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQYLVVSLA LCATICSAAQ TRNMPIQAIA YLIGPVQSDN TQVKGNVTFT
60 70 80 90 100
QNDCGQNVHV RVQLEGLKEG KHGFHIHEKG DLTNGCLSMG AHYNPDKVDH
110 120 130 140 150
GGPDHEVRHV GDLGNLEVNS SGIIDVTYTD PVITLTGKMA VIGRGVVVHE
160 170 180 190 200
LEDDLGLGNH TDSKKTGNAG GRIACGVIGI NSDVDEWPCR DGGAGALRYS
210
FSILTVIVAL IMARSLD
Length:217
Mass (Da):23,070
Last modified:January 20, 2016 - v2
Checksum:iC970AD055AC61DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA. Translation: EDW90924.2.
RefSeqiXP_002091212.2. XM_002091176.2.

Genome annotation databases

EnsemblMetazoaiFBtr0260042; FBpp0258534; FBgn0231191.
GeneIDi6530284.
KEGGidya:Dyak_GE13524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000158 Genomic DNA. Translation: EDW90924.2.
RefSeqiXP_002091212.2. XM_002091176.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0258534.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0260042; FBpp0258534; FBgn0231191.
GeneIDi6530284.
KEGGidya:Dyak_GE13524.

Organism-specific databases

FlyBaseiFBgn0231191. Dyak\GE13524.

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
KOiK04565.
OrthoDBiEOG091G0OG2.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4P649_DROYA
AccessioniPrimary (citable) accession number: B4P649
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: September 7, 2016
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.