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B4NIQ9 (B4NIQ9_DROWI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
Name:Dwil\GK13498 EMBL EDW83773.1
ORF Names:Dwil_GK13498 EMBL EDW83773.1, GK13498 FlyBase FBgn0215506
OrganismDrosophila willistoni (Fruit fly) [Complete proteome]
Taxonomic identifier7260 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length2103 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU271113
   LigandS-adenosyl-L-methionine RuleBase RU271113
   Molecular functionChromatin regulator RuleBase RU271113
Methyltransferase RuleBase RU271113
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B4NIQ9 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 6839928735AE5562

FASTA2,103227,425
        10         20         30         40         50         60 
MATPQVKDLV LRSPAGSSDV ITFAWPLQVG HGQDKHDNGF DIIDTIKFVC DELPSISSAF 

        70         80         90        100        110        120 
EEINLHQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP AERLNKFAHP SLLRHILQLV 

       130        140        150        160        170        180 
YNAAVLEPDK LNQYEPFSPE VYGETSYELV QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA 

       190        200        210        220        230        240 
GSFPLKTCIG IEKADTPARY AERMDLFFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS 

       250        260        270        280        290        300 
STLVFVNNFA FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 

       310        320        330        340        350        360 
EIPPLKGSVS WTCKPVSYYL HVIDRTKLEQ YFQRLKTKGG DHDHVGTVRT TRDRAKREAN 

       370        380        390        400        410        420 
IGSGSAGSHH NNNHNNNHNN NNNNHQQRGA EREQSNGGTS SRHQSQSPAN VNASGAMGSG 

       430        440        450        460        470        480 
LSSGTGGGSG GNNGGVASKT TRQQAQQQQQ QQQQQQRSLD MDSTSDSDGD ATTGNGGNTT 

       490        500        510        520        530        540 
TTTNTTSTSN GGGPMTRKVW SDWCSSKGKS SQSDEEENNN TNGGGSATAS GRQSRATTNT 

       550        560        570        580        590        600 
TIQKKRKKLT RKAAIASKSA AAAQRATAEA AAVAAAAATS KDSSSKEDQP PRAASTGPGI 

       610        620        630        640        650        660 
GGGRKGRLKK GARGRKCLKI AGLDVLHKQT VLSTTGDANA KKLPAAPGTV DQQLTSLLTE 

       670        680        690        700        710        720 
NMDHNELDIP LAPQHTPYAL QILLDVFRSQ YMSMIEHMKS SAYLPQVQKQ IAQEQERMAR 

       730        740        750        760        770        780 
LKNRASQLDK QIKVLIDDSV ALLKIRMNEL GISVNSPNDL IAQAKEIVGR HKDLQHTVSK 

       790        800        810        820        830        840 
MRNEVTFYEG EQKLMLSKQL KHLPEYQKLF GNSLNGKVKM EMPQELSETT AQELVLKEIA 

       850        860        870        880        890        900 
NTLSQRKKLY AQVSTIEQET SVLQKTAEER TTAAALLAQG TNISLAASSS SNSGSTNNPA 

       910        920        930        940        950        960 
PPPPPLPPAS SSSSSVAVAA TSLAAAAPSA SSLSVSVPNC KMTTTTNSSS TTNNHVKSAR 

       970        980        990       1000       1010       1020 
RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKIVETCRQI EAGHYQVNGK NKTNAEMNQQ 

      1030       1040       1050       1060       1070       1080 
TPPPPPATTT STAAVKSMYK DSTLMPAPKQ QQQQQQQQQM QLLSSILPKC ELPGLLSSSI 

      1090       1100       1110       1120       1130       1140 
LNSASSSSSS SSSSIMGRSA VSSIKQESPK VANFEDRLKS IITTALNEDQ EQRSKASTTA 

      1150       1160       1170       1180       1190       1200 
MDSLPPPTPT QSPAPKRSKP QQQHHHHHHN NNHHQQQQQQ QQHQQQSQMH PLHNIITVST 

      1210       1220       1230       1240       1250       1260 
QGLMHLNANT TISPITPPLP GPAAGATAST APPPPANLPY GAGVYGGKNH GGKYHHQMPI 

      1270       1280       1290       1300       1310       1320 
KESKYSPAAR HGQHAQLTPT PTSSSSHMAN LYGPTGPGVG SASSANANPP PPAAAAAAND 

      1330       1340       1350       1360       1370       1380 
LSYGQRRRGT VSASSYEHFM VQQQQQQQQH ALMLAAAAHA AQRQQMRTEE QPQPQQHRLP 

      1390       1400       1410       1420       1430       1440 
QHHLLHHQQQ QQQQHHSHPA HHHPNEFKTP AENLQLQRSS SREQLMLVEQ QQAPPSHIEL 

      1450       1460       1470       1480       1490       1500 
LPRSSSANSL DYGSNASSTG GGYRVRPPSR PSSNSSQPDY TQVSPAKMAL RRHLSQEKLN 

      1510       1520       1530       1540       1550       1560 
QPPQATSTPP TGQQTPSSGG GKTIGDLVNG EIERTLEISQ QSIINVAVNM STTGVGAAAA 

      1570       1580       1590       1600       1610       1620 
AHFMDRAFPN ERLLINLNAQ RPERVNIRPI QDDHHAGGSS TDQPTNYSQQ QQQQQQATAS 

      1630       1640       1650       1660       1670       1680 
GSNLATLAHV AYAQKSQRPM STSSASASAI NPSRSGRDYQ PVALPRAEMK GCIEAYFHEE 

      1690       1700       1710       1720       1730       1740 
QQQQQQQQKT KNAAVGGVGR ASRLNGANPP LEGLAASLQD HVRARKYKEE NEERQRRAAA 

      1750       1760       1770       1780       1790       1800 
AASSSSANAA SSSSSSGGGP STELNPHYAH QAPPAHTYLH MQQQQQQHHQ PNSHQHLNGT 

      1810       1820       1830       1840       1850       1860 
PHKVEIGIKR TSPLAPHQQP PRPAKLAHFE TQQQQPHLYA NGQVVLPPPP AAHEATTTPS 

      1870       1880       1890       1900       1910       1920 
PTPSSSSSSC GAGGGGGGRR SKLLIDPPLL MSPEINSLMV DERSLPLSVH HNHQQQQQQQ 

      1930       1940       1950       1960       1970       1980 
HLHHNHHHPH AHQVAQQQQQ AHRLPLHGQA TLNMNATRGN SSSSSSSSNN NNNANAADDG 

      1990       2000       2010       2020       2030       2040 
KPYVGHLIAP LPSPTSTTTT ITAATTTTLS HLTQLKAQQQ SVRCRTRLVA AQAVPEDLTI 

      2050       2060       2070       2080       2090       2100 
KKPIQAISSI SSSSSSSSSS SSSSSTSSSE DNDDDDDYND DKDDDGDNCS ESTDTAVSYY 


THA 

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14030-0811.24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH964272 Genomic DNA. Translation: EDW83773.1.
RefSeqXP_002072787.1. XM_002072751.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7260.FBpp0242641.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0244149; FBpp0242641; FBgn0215506.
GeneID6650725.
KEGGdwi:Dwil_GK13498.

Organism-specific databases

FlyBaseFBgn0215506. Dwil\GK13498.

Phylogenomic databases

eggNOGNOG294902.
InParanoidB4NIQ9.
KOK11427.
OMAQVSPAKM.
OrthoDBEOG7W6WJV.
PhylomeDBB4NIQ9.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4NIQ9_DROWI
AccessionPrimary (citable) accession number: B4NIQ9
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)