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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dwil\GK13498

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:Dwil\GK13498Imported
ORF Names:Dwil_GK13498Imported, GK13498Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0215506. Dwil\GK13498.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0242641.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 336318DOT1InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili704 – 73835Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3924. Eukaryota.
ENOG410XSYC. LUCA.
InParanoidiB4NIQ9.
KOiK11427.
OMAiYFQRLKT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 6 hits.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4NIQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPQVKDLV LRSPAGSSDV ITFAWPLQVG HGQDKHDNGF DIIDTIKFVC
60 70 80 90 100
DELPSISSAF EEINLHQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP
110 120 130 140 150
AERLNKFAHP SLLRHILQLV YNAAVLEPDK LNQYEPFSPE VYGETSYELV
160 170 180 190 200
QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY
210 220 230 240 250
AERMDLFFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS STLVFVNNFA
260 270 280 290 300
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS
310 320 330 340 350
EIPPLKGSVS WTCKPVSYYL HVIDRTKLEQ YFQRLKTKGG DHDHVGTVRT
360 370 380 390 400
TRDRAKREAN IGSGSAGSHH NNNHNNNHNN NNNNHQQRGA EREQSNGGTS
410 420 430 440 450
SRHQSQSPAN VNASGAMGSG LSSGTGGGSG GNNGGVASKT TRQQAQQQQQ
460 470 480 490 500
QQQQQQRSLD MDSTSDSDGD ATTGNGGNTT TTTNTTSTSN GGGPMTRKVW
510 520 530 540 550
SDWCSSKGKS SQSDEEENNN TNGGGSATAS GRQSRATTNT TIQKKRKKLT
560 570 580 590 600
RKAAIASKSA AAAQRATAEA AAVAAAAATS KDSSSKEDQP PRAASTGPGI
610 620 630 640 650
GGGRKGRLKK GARGRKCLKI AGLDVLHKQT VLSTTGDANA KKLPAAPGTV
660 670 680 690 700
DQQLTSLLTE NMDHNELDIP LAPQHTPYAL QILLDVFRSQ YMSMIEHMKS
710 720 730 740 750
SAYLPQVQKQ IAQEQERMAR LKNRASQLDK QIKVLIDDSV ALLKIRMNEL
760 770 780 790 800
GISVNSPNDL IAQAKEIVGR HKDLQHTVSK MRNEVTFYEG EQKLMLSKQL
810 820 830 840 850
KHLPEYQKLF GNSLNGKVKM EMPQELSETT AQELVLKEIA NTLSQRKKLY
860 870 880 890 900
AQVSTIEQET SVLQKTAEER TTAAALLAQG TNISLAASSS SNSGSTNNPA
910 920 930 940 950
PPPPPLPPAS SSSSSVAVAA TSLAAAAPSA SSLSVSVPNC KMTTTTNSSS
960 970 980 990 1000
TTNNHVKSAR RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKIVETCRQI
1010 1020 1030 1040 1050
EAGHYQVNGK NKTNAEMNQQ TPPPPPATTT STAAVKSMYK DSTLMPAPKQ
1060 1070 1080 1090 1100
QQQQQQQQQM QLLSSILPKC ELPGLLSSSI LNSASSSSSS SSSSIMGRSA
1110 1120 1130 1140 1150
VSSIKQESPK VANFEDRLKS IITTALNEDQ EQRSKASTTA MDSLPPPTPT
1160 1170 1180 1190 1200
QSPAPKRSKP QQQHHHQQQH QQQSQMHPLH NIITVSTQGL MHLNANTTIS
1210 1220 1230 1240 1250
PITPPLPGPA AGATASTAPP PPANLPYGAG VYGGKNHGGK YHHQMPIKES
1260 1270 1280 1290 1300
KYSPAARHGQ HAQLTPTPTS SSSHMANLYG PTGPGVGSAS SANANPPPPA
1310 1320 1330 1340 1350
AAAAANDLSY GQRRRGTVSA SSYEHFMVQQ QQQQQQHALM LAAAAHAAQR
1360 1370 1380 1390 1400
QQMRTEEQPQ PQQHRLPQHH LLHHQQQQQQ QHHSHPAHHH PNEFKTPAEN
1410 1420 1430 1440 1450
LQLQRSSSRE QLMLVEQQQA PPSHIELLPR SSSANSLDYG SNASSTGGGY
1460 1470 1480 1490 1500
RVRPPSRPSS NSSQPDYTQV SPAKMALRRH LSQEKLNQPP QATSTPPTGQ
1510 1520 1530 1540 1550
QTPSSGGGKT IGDLVNGEIE RTLEISQQSI INVAVNMSTT GVGAAAAAHF
1560 1570 1580 1590 1600
MDRAFPNERL LINLNAQRPE RVNIRPIQDD HHAGGSSTDQ PTNYSQQQQQ
1610 1620 1630 1640 1650
QQQATASGSN LATLAHVAYA QKSQRPMSTS SASASAINPS RSGRDYQPVA
1660 1670 1680 1690 1700
LPRAEMKGCI EAYFHEEQQQ QQQQQKTKNA AVGGVGRASR LNGANPPLEG
1710 1720 1730 1740 1750
LAASLQDHVR ARKYKEENEE RQRRAAAAAS SSSANAASSS SSSGGGPSTE
1760 1770 1780 1790 1800
LNPHYAHQAP PAHTYLHMQQ QQQQHHQPNS HQHLNGTPHK VEIGIKRTSP
1810 1820 1830 1840 1850
LAPHQQPPRP AKLAHFETQQ QQPHLYANGQ VVLPPPPAAH EATTTPSPTP
1860 1870 1880 1890 1900
SSSSSSCGAG GGGGGRRSKL LIDPPLLMSP EINSLMVDER SLPLSVHHNH
1910 1920 1930 1940 1950
QQQQQQQHLH HNHHHPHAHQ VAQQQQQAHR LPLHGQATLN MNATRGNSSS
1960 1970 1980 1990 2000
SSSSSNNNNN ANAADDDDVI AADDESHWQH RVSSGFDRLV AFASTELDKT
2010 2020 2030 2040 2050
RRSIDGDTVP ASISCNTSPD SGITTHSSSN SDAARTFLST SSSSSQLELP
2060 2070 2080 2090 2100
PSSGSSSSNQ SLYNSQQAHN QQQHLHHGAQ QLAQPQLPQP HHLNAADHLS
2110 2120 2130 2140 2150
DSSMKSTASS SLAAGTSLKT ISPVDPSAIE SPPLSDVGLP RTPSPSAVSV
2160 2170 2180 2190 2200
ATPPPIAANA GPPQTMPMAN ELRIPLKYQR KSKIGSEKHY KKKFCERNWE
2210 2220 2230 2240 2250
YDCEDELLAY SNLSAPATAA DAAGNGPGVM DSSGGGGGGG LNANPKSGKS
2260 2270 2280 2290 2300
PKDKSSPHQQ QQHQQQQHHH KSSKFRPKGK DWDWSLDSRS QTGELMPTPN
2310
TTSGSHNNNS SSATTTSN
Length:2,318
Mass (Da):250,020
Last modified:January 20, 2016 - v2
Checksum:iEF53A3C2B5832BD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964272 Genomic DNA. Translation: EDW83773.2.
RefSeqiXP_002072787.2. XM_002072751.2.

Genome annotation databases

EnsemblMetazoaiFBtr0244149; FBpp0242641; FBgn0215506.
GeneIDi6650725.
KEGGidwi:Dwil_GK13498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964272 Genomic DNA. Translation: EDW83773.2.
RefSeqiXP_002072787.2. XM_002072751.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0242641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0244149; FBpp0242641; FBgn0215506.
GeneIDi6650725.
KEGGidwi:Dwil_GK13498.

Organism-specific databases

FlyBaseiFBgn0215506. Dwil\GK13498.

Phylogenomic databases

eggNOGiKOG3924. Eukaryota.
ENOG410XSYC. LUCA.
InParanoidiB4NIQ9.
KOiK11427.
OMAiYFQRLKT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 6 hits.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiB4NIQ9_DROWI
AccessioniPrimary (citable) accession number: B4NIQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: April 13, 2016
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.