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B4NIQ9

- B4NIQ9_DROWI

UniProt

B4NIQ9 - B4NIQ9_DROWI

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
Dwil\GK13498, Dwil_GK13498, GK13498
Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
Name:Dwil\GK13498Imported
ORF Names:Dwil_GK13498Imported, GK13498Imported
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0215506. Dwil\GK13498.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0242641.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiB4NIQ9.
KOiK11427.
OMAiQVSPAKM.
OrthoDBiEOG7W6WJV.
PhylomeDBiB4NIQ9.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4NIQ9-1 [UniParc]FASTAAdd to Basket

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MATPQVKDLV LRSPAGSSDV ITFAWPLQVG HGQDKHDNGF DIIDTIKFVC     50
DELPSISSAF EEINLHQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP 100
AERLNKFAHP SLLRHILQLV YNAAVLEPDK LNQYEPFSPE VYGETSYELV 150
QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY 200
AERMDLFFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS STLVFVNNFA 250
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 300
EIPPLKGSVS WTCKPVSYYL HVIDRTKLEQ YFQRLKTKGG DHDHVGTVRT 350
TRDRAKREAN IGSGSAGSHH NNNHNNNHNN NNNNHQQRGA EREQSNGGTS 400
SRHQSQSPAN VNASGAMGSG LSSGTGGGSG GNNGGVASKT TRQQAQQQQQ 450
QQQQQQRSLD MDSTSDSDGD ATTGNGGNTT TTTNTTSTSN GGGPMTRKVW 500
SDWCSSKGKS SQSDEEENNN TNGGGSATAS GRQSRATTNT TIQKKRKKLT 550
RKAAIASKSA AAAQRATAEA AAVAAAAATS KDSSSKEDQP PRAASTGPGI 600
GGGRKGRLKK GARGRKCLKI AGLDVLHKQT VLSTTGDANA KKLPAAPGTV 650
DQQLTSLLTE NMDHNELDIP LAPQHTPYAL QILLDVFRSQ YMSMIEHMKS 700
SAYLPQVQKQ IAQEQERMAR LKNRASQLDK QIKVLIDDSV ALLKIRMNEL 750
GISVNSPNDL IAQAKEIVGR HKDLQHTVSK MRNEVTFYEG EQKLMLSKQL 800
KHLPEYQKLF GNSLNGKVKM EMPQELSETT AQELVLKEIA NTLSQRKKLY 850
AQVSTIEQET SVLQKTAEER TTAAALLAQG TNISLAASSS SNSGSTNNPA 900
PPPPPLPPAS SSSSSVAVAA TSLAAAAPSA SSLSVSVPNC KMTTTTNSSS 950
TTNNHVKSAR RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKIVETCRQI 1000
EAGHYQVNGK NKTNAEMNQQ TPPPPPATTT STAAVKSMYK DSTLMPAPKQ 1050
QQQQQQQQQM QLLSSILPKC ELPGLLSSSI LNSASSSSSS SSSSIMGRSA 1100
VSSIKQESPK VANFEDRLKS IITTALNEDQ EQRSKASTTA MDSLPPPTPT 1150
QSPAPKRSKP QQQHHHHHHN NNHHQQQQQQ QQHQQQSQMH PLHNIITVST 1200
QGLMHLNANT TISPITPPLP GPAAGATAST APPPPANLPY GAGVYGGKNH 1250
GGKYHHQMPI KESKYSPAAR HGQHAQLTPT PTSSSSHMAN LYGPTGPGVG 1300
SASSANANPP PPAAAAAAND LSYGQRRRGT VSASSYEHFM VQQQQQQQQH 1350
ALMLAAAAHA AQRQQMRTEE QPQPQQHRLP QHHLLHHQQQ QQQQHHSHPA 1400
HHHPNEFKTP AENLQLQRSS SREQLMLVEQ QQAPPSHIEL LPRSSSANSL 1450
DYGSNASSTG GGYRVRPPSR PSSNSSQPDY TQVSPAKMAL RRHLSQEKLN 1500
QPPQATSTPP TGQQTPSSGG GKTIGDLVNG EIERTLEISQ QSIINVAVNM 1550
STTGVGAAAA AHFMDRAFPN ERLLINLNAQ RPERVNIRPI QDDHHAGGSS 1600
TDQPTNYSQQ QQQQQQATAS GSNLATLAHV AYAQKSQRPM STSSASASAI 1650
NPSRSGRDYQ PVALPRAEMK GCIEAYFHEE QQQQQQQQKT KNAAVGGVGR 1700
ASRLNGANPP LEGLAASLQD HVRARKYKEE NEERQRRAAA AASSSSANAA 1750
SSSSSSGGGP STELNPHYAH QAPPAHTYLH MQQQQQQHHQ PNSHQHLNGT 1800
PHKVEIGIKR TSPLAPHQQP PRPAKLAHFE TQQQQPHLYA NGQVVLPPPP 1850
AAHEATTTPS PTPSSSSSSC GAGGGGGGRR SKLLIDPPLL MSPEINSLMV 1900
DERSLPLSVH HNHQQQQQQQ HLHHNHHHPH AHQVAQQQQQ AHRLPLHGQA 1950
TLNMNATRGN SSSSSSSSNN NNNANAADDG KPYVGHLIAP LPSPTSTTTT 2000
ITAATTTTLS HLTQLKAQQQ SVRCRTRLVA AQAVPEDLTI KKPIQAISSI 2050
SSSSSSSSSS SSSSSTSSSE DNDDDDDYND DKDDDGDNCS ESTDTAVSYY 2100
THA 2103
Length:2,103
Mass (Da):227,425
Last modified:September 23, 2008 - v1
Checksum:i6839928735AE5562
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH964272 Genomic DNA. Translation: EDW83773.1.
RefSeqiXP_002072787.1. XM_002072751.1.

Genome annotation databases

EnsemblMetazoaiFBtr0244149; FBpp0242641; FBgn0215506.
GeneIDi6650725.
KEGGidwi:Dwil_GK13498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH964272 Genomic DNA. Translation: EDW83773.1 .
RefSeqi XP_002072787.1. XM_002072751.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0242641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0244149 ; FBpp0242641 ; FBgn0215506 .
GeneIDi 6650725.
KEGGi dwi:Dwil_GK13498.

Organism-specific databases

FlyBasei FBgn0215506. Dwil\GK13498.

Phylogenomic databases

eggNOGi NOG294902.
InParanoidi B4NIQ9.
KOi K11427.
OMAi QVSPAKM.
OrthoDBi EOG7W6WJV.
PhylomeDBi B4NIQ9.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24.

Entry informationi

Entry nameiB4NIQ9_DROWI
AccessioniPrimary (citable) accession number: B4NIQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3