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B4NIQ9

- B4NIQ9_DROWI

UniProt

B4NIQ9 - B4NIQ9_DROWI

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dwil\GK13498

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    Name:Dwil\GK13498Imported
    ORF Names:Dwil_GK13498Imported, GK13498Imported
    OrganismiDrosophila willistoni (Fruit fly)Imported
    Taxonomic identifieri7260 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007798: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0215506. Dwil\GK13498.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi7260.FBpp0242641.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    InParanoidiB4NIQ9.
    KOiK11427.
    OMAiQVSPAKM.
    OrthoDBiEOG7W6WJV.
    PhylomeDBiB4NIQ9.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4NIQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPQVKDLV LRSPAGSSDV ITFAWPLQVG HGQDKHDNGF DIIDTIKFVC     50
    DELPSISSAF EEINLHQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP 100
    AERLNKFAHP SLLRHILQLV YNAAVLEPDK LNQYEPFSPE VYGETSYELV 150
    QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY 200
    AERMDLFFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS STLVFVNNFA 250
    FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 300
    EIPPLKGSVS WTCKPVSYYL HVIDRTKLEQ YFQRLKTKGG DHDHVGTVRT 350
    TRDRAKREAN IGSGSAGSHH NNNHNNNHNN NNNNHQQRGA EREQSNGGTS 400
    SRHQSQSPAN VNASGAMGSG LSSGTGGGSG GNNGGVASKT TRQQAQQQQQ 450
    QQQQQQRSLD MDSTSDSDGD ATTGNGGNTT TTTNTTSTSN GGGPMTRKVW 500
    SDWCSSKGKS SQSDEEENNN TNGGGSATAS GRQSRATTNT TIQKKRKKLT 550
    RKAAIASKSA AAAQRATAEA AAVAAAAATS KDSSSKEDQP PRAASTGPGI 600
    GGGRKGRLKK GARGRKCLKI AGLDVLHKQT VLSTTGDANA KKLPAAPGTV 650
    DQQLTSLLTE NMDHNELDIP LAPQHTPYAL QILLDVFRSQ YMSMIEHMKS 700
    SAYLPQVQKQ IAQEQERMAR LKNRASQLDK QIKVLIDDSV ALLKIRMNEL 750
    GISVNSPNDL IAQAKEIVGR HKDLQHTVSK MRNEVTFYEG EQKLMLSKQL 800
    KHLPEYQKLF GNSLNGKVKM EMPQELSETT AQELVLKEIA NTLSQRKKLY 850
    AQVSTIEQET SVLQKTAEER TTAAALLAQG TNISLAASSS SNSGSTNNPA 900
    PPPPPLPPAS SSSSSVAVAA TSLAAAAPSA SSLSVSVPNC KMTTTTNSSS 950
    TTNNHVKSAR RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKIVETCRQI 1000
    EAGHYQVNGK NKTNAEMNQQ TPPPPPATTT STAAVKSMYK DSTLMPAPKQ 1050
    QQQQQQQQQM QLLSSILPKC ELPGLLSSSI LNSASSSSSS SSSSIMGRSA 1100
    VSSIKQESPK VANFEDRLKS IITTALNEDQ EQRSKASTTA MDSLPPPTPT 1150
    QSPAPKRSKP QQQHHHHHHN NNHHQQQQQQ QQHQQQSQMH PLHNIITVST 1200
    QGLMHLNANT TISPITPPLP GPAAGATAST APPPPANLPY GAGVYGGKNH 1250
    GGKYHHQMPI KESKYSPAAR HGQHAQLTPT PTSSSSHMAN LYGPTGPGVG 1300
    SASSANANPP PPAAAAAAND LSYGQRRRGT VSASSYEHFM VQQQQQQQQH 1350
    ALMLAAAAHA AQRQQMRTEE QPQPQQHRLP QHHLLHHQQQ QQQQHHSHPA 1400
    HHHPNEFKTP AENLQLQRSS SREQLMLVEQ QQAPPSHIEL LPRSSSANSL 1450
    DYGSNASSTG GGYRVRPPSR PSSNSSQPDY TQVSPAKMAL RRHLSQEKLN 1500
    QPPQATSTPP TGQQTPSSGG GKTIGDLVNG EIERTLEISQ QSIINVAVNM 1550
    STTGVGAAAA AHFMDRAFPN ERLLINLNAQ RPERVNIRPI QDDHHAGGSS 1600
    TDQPTNYSQQ QQQQQQATAS GSNLATLAHV AYAQKSQRPM STSSASASAI 1650
    NPSRSGRDYQ PVALPRAEMK GCIEAYFHEE QQQQQQQQKT KNAAVGGVGR 1700
    ASRLNGANPP LEGLAASLQD HVRARKYKEE NEERQRRAAA AASSSSANAA 1750
    SSSSSSGGGP STELNPHYAH QAPPAHTYLH MQQQQQQHHQ PNSHQHLNGT 1800
    PHKVEIGIKR TSPLAPHQQP PRPAKLAHFE TQQQQPHLYA NGQVVLPPPP 1850
    AAHEATTTPS PTPSSSSSSC GAGGGGGGRR SKLLIDPPLL MSPEINSLMV 1900
    DERSLPLSVH HNHQQQQQQQ HLHHNHHHPH AHQVAQQQQQ AHRLPLHGQA 1950
    TLNMNATRGN SSSSSSSSNN NNNANAADDG KPYVGHLIAP LPSPTSTTTT 2000
    ITAATTTTLS HLTQLKAQQQ SVRCRTRLVA AQAVPEDLTI KKPIQAISSI 2050
    SSSSSSSSSS SSSSSTSSSE DNDDDDDYND DKDDDGDNCS ESTDTAVSYY 2100
    THA 2103
    Length:2,103
    Mass (Da):227,425
    Last modified:September 23, 2008 - v1
    Checksum:i6839928735AE5562
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH964272 Genomic DNA. Translation: EDW83773.1.
    RefSeqiXP_002072787.1. XM_002072751.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0244149; FBpp0242641; FBgn0215506.
    GeneIDi6650725.
    KEGGidwi:Dwil_GK13498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH964272 Genomic DNA. Translation: EDW83773.1 .
    RefSeqi XP_002072787.1. XM_002072751.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7260.FBpp0242641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0244149 ; FBpp0242641 ; FBgn0215506 .
    GeneIDi 6650725.
    KEGGi dwi:Dwil_GK13498.

    Organism-specific databases

    FlyBasei FBgn0215506. Dwil\GK13498.

    Phylogenomic databases

    eggNOGi NOG294902.
    InParanoidi B4NIQ9.
    KOi K11427.
    OMAi QVSPAKM.
    OrthoDBi EOG7W6WJV.
    PhylomeDBi B4NIQ9.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14030-0811.24Imported.

    Entry informationi

    Entry nameiB4NIQ9_DROWI
    AccessioniPrimary (citable) accession number: B4NIQ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3