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B4NIQ9

- B4NIQ9_DROWI

UniProt

B4NIQ9 - B4NIQ9_DROWI

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dwil\GK13498

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:Dwil\GK13498Imported
ORF Names:Dwil_GK13498Imported, GK13498Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0215506. Dwil\GK13498.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0242641.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiB4NIQ9.
KOiK11427.
OMAiQVSPAKM.
OrthoDBiEOG7W6WJV.
PhylomeDBiB4NIQ9.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4NIQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPQVKDLV LRSPAGSSDV ITFAWPLQVG HGQDKHDNGF DIIDTIKFVC
60 70 80 90 100
DELPSISSAF EEINLHQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP
110 120 130 140 150
AERLNKFAHP SLLRHILQLV YNAAVLEPDK LNQYEPFSPE VYGETSYELV
160 170 180 190 200
QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY
210 220 230 240 250
AERMDLFFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS STLVFVNNFA
260 270 280 290 300
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS
310 320 330 340 350
EIPPLKGSVS WTCKPVSYYL HVIDRTKLEQ YFQRLKTKGG DHDHVGTVRT
360 370 380 390 400
TRDRAKREAN IGSGSAGSHH NNNHNNNHNN NNNNHQQRGA EREQSNGGTS
410 420 430 440 450
SRHQSQSPAN VNASGAMGSG LSSGTGGGSG GNNGGVASKT TRQQAQQQQQ
460 470 480 490 500
QQQQQQRSLD MDSTSDSDGD ATTGNGGNTT TTTNTTSTSN GGGPMTRKVW
510 520 530 540 550
SDWCSSKGKS SQSDEEENNN TNGGGSATAS GRQSRATTNT TIQKKRKKLT
560 570 580 590 600
RKAAIASKSA AAAQRATAEA AAVAAAAATS KDSSSKEDQP PRAASTGPGI
610 620 630 640 650
GGGRKGRLKK GARGRKCLKI AGLDVLHKQT VLSTTGDANA KKLPAAPGTV
660 670 680 690 700
DQQLTSLLTE NMDHNELDIP LAPQHTPYAL QILLDVFRSQ YMSMIEHMKS
710 720 730 740 750
SAYLPQVQKQ IAQEQERMAR LKNRASQLDK QIKVLIDDSV ALLKIRMNEL
760 770 780 790 800
GISVNSPNDL IAQAKEIVGR HKDLQHTVSK MRNEVTFYEG EQKLMLSKQL
810 820 830 840 850
KHLPEYQKLF GNSLNGKVKM EMPQELSETT AQELVLKEIA NTLSQRKKLY
860 870 880 890 900
AQVSTIEQET SVLQKTAEER TTAAALLAQG TNISLAASSS SNSGSTNNPA
910 920 930 940 950
PPPPPLPPAS SSSSSVAVAA TSLAAAAPSA SSLSVSVPNC KMTTTTNSSS
960 970 980 990 1000
TTNNHVKSAR RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKIVETCRQI
1010 1020 1030 1040 1050
EAGHYQVNGK NKTNAEMNQQ TPPPPPATTT STAAVKSMYK DSTLMPAPKQ
1060 1070 1080 1090 1100
QQQQQQQQQM QLLSSILPKC ELPGLLSSSI LNSASSSSSS SSSSIMGRSA
1110 1120 1130 1140 1150
VSSIKQESPK VANFEDRLKS IITTALNEDQ EQRSKASTTA MDSLPPPTPT
1160 1170 1180 1190 1200
QSPAPKRSKP QQQHHHHHHN NNHHQQQQQQ QQHQQQSQMH PLHNIITVST
1210 1220 1230 1240 1250
QGLMHLNANT TISPITPPLP GPAAGATAST APPPPANLPY GAGVYGGKNH
1260 1270 1280 1290 1300
GGKYHHQMPI KESKYSPAAR HGQHAQLTPT PTSSSSHMAN LYGPTGPGVG
1310 1320 1330 1340 1350
SASSANANPP PPAAAAAAND LSYGQRRRGT VSASSYEHFM VQQQQQQQQH
1360 1370 1380 1390 1400
ALMLAAAAHA AQRQQMRTEE QPQPQQHRLP QHHLLHHQQQ QQQQHHSHPA
1410 1420 1430 1440 1450
HHHPNEFKTP AENLQLQRSS SREQLMLVEQ QQAPPSHIEL LPRSSSANSL
1460 1470 1480 1490 1500
DYGSNASSTG GGYRVRPPSR PSSNSSQPDY TQVSPAKMAL RRHLSQEKLN
1510 1520 1530 1540 1550
QPPQATSTPP TGQQTPSSGG GKTIGDLVNG EIERTLEISQ QSIINVAVNM
1560 1570 1580 1590 1600
STTGVGAAAA AHFMDRAFPN ERLLINLNAQ RPERVNIRPI QDDHHAGGSS
1610 1620 1630 1640 1650
TDQPTNYSQQ QQQQQQATAS GSNLATLAHV AYAQKSQRPM STSSASASAI
1660 1670 1680 1690 1700
NPSRSGRDYQ PVALPRAEMK GCIEAYFHEE QQQQQQQQKT KNAAVGGVGR
1710 1720 1730 1740 1750
ASRLNGANPP LEGLAASLQD HVRARKYKEE NEERQRRAAA AASSSSANAA
1760 1770 1780 1790 1800
SSSSSSGGGP STELNPHYAH QAPPAHTYLH MQQQQQQHHQ PNSHQHLNGT
1810 1820 1830 1840 1850
PHKVEIGIKR TSPLAPHQQP PRPAKLAHFE TQQQQPHLYA NGQVVLPPPP
1860 1870 1880 1890 1900
AAHEATTTPS PTPSSSSSSC GAGGGGGGRR SKLLIDPPLL MSPEINSLMV
1910 1920 1930 1940 1950
DERSLPLSVH HNHQQQQQQQ HLHHNHHHPH AHQVAQQQQQ AHRLPLHGQA
1960 1970 1980 1990 2000
TLNMNATRGN SSSSSSSSNN NNNANAADDG KPYVGHLIAP LPSPTSTTTT
2010 2020 2030 2040 2050
ITAATTTTLS HLTQLKAQQQ SVRCRTRLVA AQAVPEDLTI KKPIQAISSI
2060 2070 2080 2090 2100
SSSSSSSSSS SSSSSTSSSE DNDDDDDYND DKDDDGDNCS ESTDTAVSYY

THA
Length:2,103
Mass (Da):227,425
Last modified:September 23, 2008 - v1
Checksum:i6839928735AE5562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964272 Genomic DNA. Translation: EDW83773.1.
RefSeqiXP_002072787.1. XM_002072751.1.

Genome annotation databases

EnsemblMetazoaiFBtr0244149; FBpp0242641; FBgn0215506.
GeneIDi6650725.
KEGGidwi:Dwil_GK13498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964272 Genomic DNA. Translation: EDW83773.1 .
RefSeqi XP_002072787.1. XM_002072751.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0242641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0244149 ; FBpp0242641 ; FBgn0215506 .
GeneIDi 6650725.
KEGGi dwi:Dwil_GK13498.

Organism-specific databases

FlyBasei FBgn0215506. Dwil\GK13498.

Phylogenomic databases

eggNOGi NOG294902.
InParanoidi B4NIQ9.
KOi K11427.
OMAi QVSPAKM.
OrthoDBi EOG7W6WJV.
PhylomeDBi B4NIQ9.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiB4NIQ9_DROWI
AccessioniPrimary (citable) accession number: B4NIQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3