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Protein

Mesencephalic astrocyte-derived neurotrophic factor homolog

Gene

Manf

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Mesencephalic astrocyte-derived neurotrophic factor homolog
Alternative name(s):
MANF/CDNF-like protein
Gene namesi
Name:ManfBy similarity
ORF Names:GK13778
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0215786. Dwil\GK13778.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 173151Mesencephalic astrocyte-derived neurotrophic factor homologPRO_0000390947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 114By similarity
Disulfide bondi31 ↔ 103By similarity
Disulfide bondi61 ↔ 72By similarity
Disulfide bondi148 ↔ 151By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0242921.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMET family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG301491.
InParanoidiB4NIN8.
OMAiEHRFCYY.
OrthoDBiEOG7PZS02.
PhylomeDBiB4NIN8.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
InterProiIPR019345. Armet_prot.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011001. Saposin-like.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4NIN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLHMLLVI CCLAGIYQTT LALKEEDCEV CVKTVRKFAS SLDDATKKDY
60 70 80 90 100
KLIEVAFKKY CKTQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE
110 120 130 140 150
KICEKLKKKD AQICDLRYEK QIDLNNVDLK KLKVRDLKKI LNDWDESCDG
160 170
CLEKSDFIKR IEELKPKYAH NEL
Length:173
Mass (Da):20,122
Last modified:September 22, 2008 - v1
Checksum:i1F77B3502F2A23CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964272 Genomic DNA. Translation: EDW83752.1.
RefSeqiXP_002072766.1. XM_002072730.1.

Genome annotation databases

EnsemblMetazoaiFBtr0244429; FBpp0242921; FBgn0215786.
GeneIDi6650919.
KEGGidwi:Dwil_GK13778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964272 Genomic DNA. Translation: EDW83752.1.
RefSeqiXP_002072766.1. XM_002072730.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0242921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0244429; FBpp0242921; FBgn0215786.
GeneIDi6650919.
KEGGidwi:Dwil_GK13778.

Organism-specific databases

FlyBaseiFBgn0215786. Dwil\GK13778.

Phylogenomic databases

eggNOGiNOG301491.
InParanoidiB4NIN8.
OMAiEHRFCYY.
OrthoDBiEOG7PZS02.
PhylomeDBiB4NIN8.

Miscellaneous databases

ChiTaRSiManf. fly.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
InterProiIPR019345. Armet_prot.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011001. Saposin-like.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiARMET_DROWI
AccessioniPrimary (citable) accession number: B4NIN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 18, 2010
Last sequence update: September 22, 2008
Last modified: January 6, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.