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B4NE96

- PGAM5_DROWI

UniProt

B4NE96 - PGAM5_DROWI

Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5 homologBy similarity
    Gene namesi
    Name:Pgam5By similarity
    ORF Names:GK25607
    OrganismiDrosophila willistoni (Fruit fly)
    Taxonomic identifieri7260 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007798: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0227566. Dwil\GK25607.

    Subcellular locationi

    Mitochondrion outer membrane By similaritySequence Analysis; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390711Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with Pk92B/ASK1.By similarity

    Protein-protein interaction databases

    STRINGi7260.FBpp0254750.

    Structurei

    3D structure databases

    ProteinModelPortaliB4NE96.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71348.
    InParanoidiB4NE96.
    KOiK15637.
    OMAiWLRMSLN.
    OrthoDBiEOG7966H1.
    PhylomeDBiB4NE96.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4NE96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKFTAFACG TGAGLAAFYL QRLRDPKQTA WVHNSWTNSE RPVDSWALWD    50
    SNWDCRDPKS LVRPQKNEQP QEQNRYNSDF EKNHAKSARH IILIRHGEYL 100
    DVGDTDDTHH LTERGREQAK FTGQRLHDLG IKWDKVIAST MVRAQETADI 150
    ILNEIDYDKA KVTNCAYLRE GAPIPPQPPV GHWKPEASQF FRDGARIEAA 200
    FRRYFHRAYP DQTKESYTLI VGHGNVIRYF VCRALQFPPE AWLRISINHA 250
    SITWLTISPS GNVSIKYLGD SGFMPVKHLT NRIPRDAKNV V 291
    Length:291
    Mass (Da):33,513
    Last modified:September 23, 2008 - v1
    Checksum:i6BBAF00BD6DCFB69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH964239 Genomic DNA. Translation: EDW82065.1.
    RefSeqiXP_002071079.1. XM_002071043.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0256258; FBpp0254750; FBgn0227566.
    GeneIDi6648756.
    KEGGidwi:Dwil_GK25607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH964239 Genomic DNA. Translation: EDW82065.1 .
    RefSeqi XP_002071079.1. XM_002071043.1.

    3D structure databases

    ProteinModelPortali B4NE96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7260.FBpp0254750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0256258 ; FBpp0254750 ; FBgn0227566 .
    GeneIDi 6648756.
    KEGGi dwi:Dwil_GK25607.

    Organism-specific databases

    FlyBasei FBgn0227566. Dwil\GK25607.

    Phylogenomic databases

    eggNOGi NOG71348.
    InParanoidi B4NE96.
    KOi K15637.
    OMAi WLRMSLN.
    OrthoDBi EOG7966H1.
    PhylomeDBi B4NE96.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14030-0811.24Imported.

    Entry informationi

    Entry nameiPGAM5_DROWI
    AccessioniPrimary (citable) accession number: B4NE96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3