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Protein

Delta-like protein

Gene

Dwil\GK11192

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:Dwil\GK11192Imported
ORF Names:Dwil_GK11192Imported, GK11192Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0213203. Dwil\GK11192.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0240335.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 25445DSLInterPro annotationAdd
BLAST
Domaini255 – 28834EGF-likeInterPro annotationAdd
BLAST
Domaini322 – 36039EGF-likeInterPro annotationAdd
BLAST
Domaini430 – 46637EGF-likeInterPro annotationAdd
BLAST
Domaini468 – 50437EGF-likeInterPro annotationAdd
BLAST
Domaini560 – 59536EGF-likeInterPro annotationAdd
BLAST
Domaini597 – 63236EGF-likeInterPro annotationAdd
BLAST
Domaini634 – 67037EGF-likeInterPro annotationAdd
BLAST
Domaini672 – 70736EGF-likeInterPro annotationAdd
BLAST
Domaini754 – 79037EGF-likeInterPro annotationAdd
BLAST
Domaini792 – 82837EGF-likeInterPro annotationAdd
BLAST
Domaini830 – 87041EGF-likeInterPro annotationAdd
BLAST
Domaini872 – 90837EGF-likeInterPro annotationAdd
BLAST
Domaini910 – 94637EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.UniRule annotation
Contains 14 EGF-like domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
InParanoidiB4NBF4.
KOiK06052.
OrthoDBiEOG091G0A88.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 13 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4NBF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTWQRQKQ KPKPKPRETS TLALPSLIND CRSLKSACNL IALILILLVH
60 70 80 90 100
KISATGNFEL EILEISNTNN HLLSGYCCGV PTELRATKTT GCSPCTTAFR
110 120 130 140 150
LCLKEYQTTE QGASISTGCS FGNSTTKILG GSSFVLSDPG VGAIVLPFTF
160 170 180 190 200
RWTKSFTLIL QALDMYNTSY SDAERLIEET SYSGVILPSP EWKTLDHIGR
210 220 230 240 250
NARITYRVRV QCGNYYYNTT CTTFCRPRDD QFGHYACGSE GQKLCLNGWE
260 270 280 290 300
GDNCEKAICK PGCDPAHGKC DRPGECECRH GWRGPLCDEC MVYPGCKHGS
310 320 330 340 350
CNGTPWKCAC DTNWGGILCD QDLNYCGTHE PCQHGGTCEN TAPDKYRCTC
360 370 380 390 400
AEGLSGEQCE IVEHPCATQP CLNGGTCTLK QMNATRLALT YRSMHGMSSA
410 420 430 440 450
MGKPISRRNS IRSLANLRQE SASTLSSSSL LSSSSQSQSL NGSQLTPLAA
460 470 480 490 500
EFTCGCSAGW TGPTCEINID ECAGGPCEHG GTCVDLIGGF RCECPPEWRG
510 520 530 540 550
DVCQVDVNEC EAPHGHGSSL PANTLLTTTA SAIIVSNLSS SAALLAALTS
560 570 580 590 600
AVAASASASN AATTIGPCIN ARECLNLPGS FSCVCLEGWG GPTCAENLDD
610 620 630 640 650
CMGQCKNGAS CIDLVNDYRC ACAPGYTGRD CETDIDECAT SPCRNGGECV
660 670 680 690 700
DMVGKFNCIC PLGYSGSLCE EAKDHCTPSP CLQGRCLNTP GSYYCHCPPD
710 720 730 740 750
RAGKHCEQLR PLCSQPPCNE GCFANVSSSS STAATKTKVA TTTTTMTTTT
760 770 780 790 800
TTTTMSTANA VPCSGHGSCE MSDVGTFCKC HVGHTGTFCE HNLNECSPNP
810 820 830 840 850
CRNGGICLDG DGDFTCECMS GWTGKRCSER ATGCYAGQCQ NGGTCMPGAP
860 870 880 890 900
DKALQPYCRC ARGWTGPFCA EAIDQCRGQP CNNGGTCESG AGWFRCVCAQ
910 920 930 940 950
GFSGPDCLIN VNECSPQPCQ GGATCIDGIG GYSCICPPGR HGLRCEILLS
960 970 980 990 1000
DPKSACLNAS NTISPYTALN QSQNWLDMAL SGHSEEDEYC NSCVCENGTS
1010 1020 1030 1040 1050
RCTNLWCGLT NCFKLDPLSK SSNLSGVCRQ HEVCVPALSE TCLAPPCQVR
1060 1070 1080 1090 1100
GDCRSLEPSR RVAPPRLPAK ASCWPNQALV NENCARLTIL LDLERVGKGA
1110 1120 1130 1140 1150
SVEGLCSLVR VLLAARLVKQ PMNNSGQEQG LLMVLCDLKT ATNDTIELTV
1160 1170 1180 1190 1200
SSSKLNDPQL PAAVLLLGEL LSSRQLNGIQ RRKELELKHA KLAALTSILE
1210 1220 1230 1240 1250
VKLETARIAD GSGHSLLIGV LCGIFIVLVG FSIFISLYWK QRMAYRSSSG
1260 1270 1280 1290 1300
MNLTPPLDAL RHEEEKSNNL QNEENLRRYT NPLKGSTSSL RATTGMELSL
1310 1320 1330 1340 1350
NPAPELAASA ASSSALHRSQ PLFPPCDFER ELDSGTGLKQ AHKRSSQILL
1360 1370 1380 1390 1400
HKTQNSDMKK NTVGSLDSPR KDFGKRSINC KSMPPPACDD NGDILTTVVV
Length:1,400
Mass (Da):149,644
Last modified:January 20, 2016 - v2
Checksum:i991D2986B759A942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964232 Genomic DNA. Translation: EDW81118.2.
RefSeqiXP_002070132.2. XM_002070096.2.

Genome annotation databases

EnsemblMetazoaiFBtr0241843; FBpp0240335; FBgn0213203.
GeneIDi6647176.
KEGGidwi:Dwil_GK11192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964232 Genomic DNA. Translation: EDW81118.2.
RefSeqiXP_002070132.2. XM_002070096.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0240335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0241843; FBpp0240335; FBgn0213203.
GeneIDi6647176.
KEGGidwi:Dwil_GK11192.

Organism-specific databases

FlyBaseiFBgn0213203. Dwil\GK11192.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
InParanoidiB4NBF4.
KOiK06052.
OrthoDBiEOG091G0A88.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 13 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4NBF4_DROWI
AccessioniPrimary (citable) accession number: B4NBF4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: September 7, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.