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Protein

Delta-like protein

Gene

Dwil\GK11192

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:Dwil\GK11192Imported
ORF Names:Dwil_GK11192Imported, GK11192Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0213203 Dwil\GK11192

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi212 ↔ 221PROSITE-ProRule annotation
Disulfide bondi225 ↔ 237PROSITE-ProRule annotation
Disulfide bondi245 ↔ 254PROSITE-ProRule annotation
Disulfide bondi278 ↔ 287PROSITE-ProRule annotation
Disulfide bondi350 ↔ 359PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi494 ↔ 503PROSITE-ProRule annotation
Disulfide bondi564 ↔ 574PROSITE-ProRule annotation
Disulfide bondi585 ↔ 594PROSITE-ProRule annotation
Disulfide bondi601 ↔ 611PROSITE-ProRule annotation
Disulfide bondi622 ↔ 631PROSITE-ProRule annotation
Disulfide bondi660 ↔ 669PROSITE-ProRule annotation
Disulfide bondi676 ↔ 686PROSITE-ProRule annotation
Disulfide bondi697 ↔ 706PROSITE-ProRule annotation
Disulfide bondi780 ↔ 789PROSITE-ProRule annotation
Disulfide bondi818 ↔ 827PROSITE-ProRule annotation
Disulfide bondi860 ↔ 869PROSITE-ProRule annotation
Disulfide bondi898 ↔ 907PROSITE-ProRule annotation
Disulfide bondi936 ↔ 945PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7260.FBpp0240335

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 254DSLInterPro annotationAdd BLAST45
Domaini255 – 288EGF-likeInterPro annotationAdd BLAST34
Domaini322 – 360EGF-likeInterPro annotationAdd BLAST39
Domaini430 – 466EGF-likeInterPro annotationAdd BLAST37
Domaini468 – 504EGF-likeInterPro annotationAdd BLAST37
Domaini560 – 595EGF-likeInterPro annotationAdd BLAST36
Domaini597 – 632EGF-likeInterPro annotationAdd BLAST36
Domaini634 – 670EGF-likeInterPro annotationAdd BLAST37
Domaini672 – 707EGF-likeInterPro annotationAdd BLAST36
Domaini754 – 790EGF-likeInterPro annotationAdd BLAST37
Domaini792 – 828EGF-likeInterPro annotationAdd BLAST37
Domaini830 – 870EGF-likeInterPro annotationAdd BLAST41
Domaini872 – 908EGF-likeInterPro annotationAdd BLAST37
Domaini910 – 946EGF-likeInterPro annotationAdd BLAST37

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
InParanoidiB4NBF4
KOiK06052
OrthoDBiEOG091G0A88

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 6 hits
PF12661 hEGF, 3 hits
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 14 hits
SM00179 EGF_CA, 9 hits
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 7 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 13 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 13 hits
PS01187 EGF_CA, 4 hits

Sequencei

Sequence statusi: Complete.

B4NBF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTWQRQKQ KPKPKPRETS TLALPSLIND CRSLKSACNL IALILILLVH
60 70 80 90 100
KISATGNFEL EILEISNTNN HLLSGYCCGV PTELRATKTT GCSPCTTAFR
110 120 130 140 150
LCLKEYQTTE QGASISTGCS FGNSTTKILG GSSFVLSDPG VGAIVLPFTF
160 170 180 190 200
RWTKSFTLIL QALDMYNTSY SDAERLIEET SYSGVILPSP EWKTLDHIGR
210 220 230 240 250
NARITYRVRV QCGNYYYNTT CTTFCRPRDD QFGHYACGSE GQKLCLNGWE
260 270 280 290 300
GDNCEKAICK PGCDPAHGKC DRPGECECRH GWRGPLCDEC MVYPGCKHGS
310 320 330 340 350
CNGTPWKCAC DTNWGGILCD QDLNYCGTHE PCQHGGTCEN TAPDKYRCTC
360 370 380 390 400
AEGLSGEQCE IVEHPCATQP CLNGGTCTLK QMNATRLALT YRSMHGMSSA
410 420 430 440 450
MGKPISRRNS IRSLANLRQE SASTLSSSSL LSSSSQSQSL NGSQLTPLAA
460 470 480 490 500
EFTCGCSAGW TGPTCEINID ECAGGPCEHG GTCVDLIGGF RCECPPEWRG
510 520 530 540 550
DVCQVDVNEC EAPHGHGSSL PANTLLTTTA SAIIVSNLSS SAALLAALTS
560 570 580 590 600
AVAASASASN AATTIGPCIN ARECLNLPGS FSCVCLEGWG GPTCAENLDD
610 620 630 640 650
CMGQCKNGAS CIDLVNDYRC ACAPGYTGRD CETDIDECAT SPCRNGGECV
660 670 680 690 700
DMVGKFNCIC PLGYSGSLCE EAKDHCTPSP CLQGRCLNTP GSYYCHCPPD
710 720 730 740 750
RAGKHCEQLR PLCSQPPCNE GCFANVSSSS STAATKTKVA TTTTTMTTTT
760 770 780 790 800
TTTTMSTANA VPCSGHGSCE MSDVGTFCKC HVGHTGTFCE HNLNECSPNP
810 820 830 840 850
CRNGGICLDG DGDFTCECMS GWTGKRCSER ATGCYAGQCQ NGGTCMPGAP
860 870 880 890 900
DKALQPYCRC ARGWTGPFCA EAIDQCRGQP CNNGGTCESG AGWFRCVCAQ
910 920 930 940 950
GFSGPDCLIN VNECSPQPCQ GGATCIDGIG GYSCICPPGR HGLRCEILLS
960 970 980 990 1000
DPKSACLNAS NTISPYTALN QSQNWLDMAL SGHSEEDEYC NSCVCENGTS
1010 1020 1030 1040 1050
RCTNLWCGLT NCFKLDPLSK SSNLSGVCRQ HEVCVPALSE TCLAPPCQVR
1060 1070 1080 1090 1100
GDCRSLEPSR RVAPPRLPAK ASCWPNQALV NENCARLTIL LDLERVGKGA
1110 1120 1130 1140 1150
SVEGLCSLVR VLLAARLVKQ PMNNSGQEQG LLMVLCDLKT ATNDTIELTV
1160 1170 1180 1190 1200
SSSKLNDPQL PAAVLLLGEL LSSRQLNGIQ RRKELELKHA KLAALTSILE
1210 1220 1230 1240 1250
VKLETARIAD GSGHSLLIGV LCGIFIVLVG FSIFISLYWK QRMAYRSSSG
1260 1270 1280 1290 1300
MNLTPPLDAL RHEEEKSNNL QNEENLRRYT NPLKGSTSSL RATTGMELSL
1310 1320 1330 1340 1350
NPAPELAASA ASSSALHRSQ PLFPPCDFER ELDSGTGLKQ AHKRSSQILL
1360 1370 1380 1390 1400
HKTQNSDMKK NTVGSLDSPR KDFGKRSINC KSMPPPACDD NGDILTTVVV
Length:1,400
Mass (Da):149,644
Last modified:January 20, 2016 - v2
Checksum:i991D2986B759A942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964232 Genomic DNA Translation: EDW81118.2
RefSeqiXP_002070132.2, XM_002070096.2

Genome annotation databases

EnsemblMetazoaiFBtr0241843; FBpp0240335; FBgn0213203
GeneIDi6647176
KEGGidwi:Dwil_GK11192

Similar proteinsi

Entry informationi

Entry nameiB4NBF4_DROWI
AccessioniPrimary (citable) accession number: B4NBF4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: March 28, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health