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B4NBE8

- B4NBE8_DROWI

UniProt

B4NBE8 - B4NBE8_DROWI

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Protein

DNA ligase

Gene

Dwil\GK11194

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dwil\GK11194Imported
ORF Names:Dwil_GK11194Imported, GK11194Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0213205. Dwil\GK11194.

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0240337.

Structurei

3D structure databases

ProteinModelPortaliB4NBE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiB4NBE8.
KOiK10776.
OMAiNEDNKLD.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4NBE8.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4NBE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPLQNEDN KLDTFRRICD EIASESSYLR KVERLEGFFK KGSKGTVFEG
60 70 80 90 100
DFLLWVQFLI PGATQRVYNL QNKALIKLFS RILNSDQNQM QLDLEQDGDV
110 120 130 140 150
SETLRKHFAA SAKLKPQTQS KLYLQEVDEL LRQLEQKTKE DDQTELLKEL
160 170 180 190 200
CKKATELDLR TFIRLIKQDL RINARARHIL DAFGPLAYPA YQSSRDLTAI
210 220 230 240 250
VQQFAGKAVK TQAKSPAKKL KTTTSAIQVM TPISPMLANA CKSVEEAFKK
260 270 280 290 300
NPAGLFGEVK YDGERVQIHK KGKEFKFFSR NLKPVMDHKI KRLTEYIPRA
310 320 330 340 350
FPGAGDMILD SEIILVDTET GALLPFGTLG AHKKHEYANA SVCLFVFDCI
360 370 380 390 400
LYDGEDLMQL EFRKRREILE QNIEPIKSYV QLSESQFLKT KSELAMMTAK
410 420 430 440 450
VLQANLEGVV LKNPNGTYQP GKRNWLKVKK DYLFDGKMAD TADLVVLGAW
460 470 480 490 500
YGSGKKGGVL SIFLMGCYDP KDRLWKTVTK VHSGLDDSTN DEIHENLMKL
510 520 530 540 550
TTRADANKTP NWLLCKKSLV PDVLAVDPQK MPVWEITGAE FTKSEAHTAA
560 570 580 590 600
GVSIRFPRIT RLRSDKTSKE ANDLPHLLNL YEASKKNVNV DLLLANCDND
610 620 630 640 650
KDGLEKKLAQ EKTPEKRKSL ENSAKKSKKS ISKEDEDSQC SSKMIKREVN
660 670 680 690 700
KPSQKGLQYY FKPDKIQNNV KSELKTEVKT ELKTQVKSET HTAMEVDENT
710 720 730 740 750
PKQVKSKLFS GLVAHFTKDA TKSKQMQEFV QHGGSLTTNT QKAALAFYNT
760 770 780 790
NTSVNLAHLR PLYRRRCRHL TVSWLDRSIE TQTLQPYPLY AVLLKS
Length:796
Mass (Da):90,397
Last modified:September 23, 2008 - v1
Checksum:i9A7EDCD0AE46B3E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964232 Genomic DNA. Translation: EDW81112.1.
RefSeqiXP_002070126.1. XM_002070090.1.

Genome annotation databases

EnsemblMetazoaiFBtr0241845; FBpp0240337; FBgn0213205.
GeneIDi6647378.
KEGGidwi:Dwil_GK11194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964232 Genomic DNA. Translation: EDW81112.1 .
RefSeqi XP_002070126.1. XM_002070090.1.

3D structure databases

ProteinModelPortali B4NBE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0240337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0241845 ; FBpp0240337 ; FBgn0213205 .
GeneIDi 6647378.
KEGGi dwi:Dwil_GK11194.

Organism-specific databases

FlyBasei FBgn0213205. Dwil\GK11194.

Phylogenomic databases

eggNOGi COG1793.
InParanoidi B4NBE8.
KOi K10776.
OMAi NEDNKLD.
OrthoDBi EOG7BKCT2.
PhylomeDBi B4NBE8.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiB4NBE8_DROWI
AccessioniPrimary (citable) accession number: B4NBE8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3