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Protein

DNA ligase

Gene

Dwil\GK11194

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dwil\GK11194Imported
ORF Names:Dwil_GK11194Imported, GK11194Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0213205 Dwil\GK11194

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0240337

Structurei

3D structure databases

ProteinModelPortaliB4NBE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini335 – 469DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini704 – 792BRCTInterPro annotationAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili120 – 144Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
InParanoidiB4NBE8
KOiK10776
OMAiDCIYFND
OrthoDBiEOG091G0XBU
PhylomeDBiB4NBE8

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

B4NBE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPLQNEDN KLDTFRRICD EIASESSYLR KVERLEGFFK KGSKGTVFEG
60 70 80 90 100
DFLLWVQFLI PGATQRVYNL QNKALIKLFS RILNSDQNQM QLDLEQDGDV
110 120 130 140 150
SETLRKHFAA SAKLKPQTQS KLYLQEVDEL LRQLEQKTKE DDQTELLKEL
160 170 180 190 200
CKKATELDLR TFIRLIKQDL RINARARHIL DAFGPLAYPA YQSSRDLTAI
210 220 230 240 250
VQQFAGKAVK TQAKSPAKKL KTTTSAIQVM TPISPMLANA CKSVEEAFKK
260 270 280 290 300
NPAGLFGEVK YDGERVQIHK KGKEFKFFSR NLKPVMDHKI KRLTEYIPRA
310 320 330 340 350
FPGAGDMILD SEIILVDTET GALLPFGTLG AHKKHEYANA SVCLFVFDCI
360 370 380 390 400
LYDGEDLMQL EFRKRREILE QNIEPIKSYV QLSESQFLKT KSELAMMTAK
410 420 430 440 450
VLQANLEGVV LKNPNGTYQP GKRNWLKVKK DYLFDGKMAD TADLVVLGAW
460 470 480 490 500
YGSGKKGGVL SIFLMGCYDP KDRLWKTVTK VHSGLDDSTN DEIHENLMKL
510 520 530 540 550
TTRADANKTP NWLLCKKSLV PDVLAVDPQK MPVWEITGAE FTKSEAHTAA
560 570 580 590 600
GVSIRFPRIT RLRSDKTSKE ANDLPHLLNL YEASKKNVNV DLLLANCDND
610 620 630 640 650
KDGLEKKLAQ EKTPEKRKSL ENSAKKSKKS ISKEDEDSQC SSKMIKREVN
660 670 680 690 700
KPSQKGLQYY FKPDKIQNNV KSELKTEVKT ELKTQVKSET HTAMEVDENT
710 720 730 740 750
PKQVKSKLFS GLVAHFTKDA TKSKQMQEFV QHGGSLTTNT QKAALAFYNT
760 770 780 790
NTSVNLAHLR PLYRRRCRHL TVSWLDRSIE TQTLQPYPLY AVLLKS
Length:796
Mass (Da):90,397
Last modified:September 23, 2008 - v1
Checksum:i9A7EDCD0AE46B3E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964232 Genomic DNA Translation: EDW81112.1
RefSeqiXP_002070126.1, XM_002070090.2

Genome annotation databases

EnsemblMetazoaiFBtr0241845; FBpp0240337; FBgn0213205
GeneIDi6647378
KEGGidwi:Dwil_GK11194

Similar proteinsi

Entry informationi

Entry nameiB4NBE8_DROWI
AccessioniPrimary (citable) accession number: B4NBE8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health