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B4NAL6

- PDE6_DROWI

UniProt

B4NAL6 - PDE6_DROWI

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei730 – 7301Proton donorBy similarity
    Metal bindingi734 – 7341Divalent metal cation 1By similarity
    Metal bindingi770 – 7701Divalent metal cation 1By similarity
    Metal bindingi771 – 7711Divalent metal cation 1By similarity
    Metal bindingi771 – 7711Divalent metal cation 2By similarity
    Metal bindingi881 – 8811Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GK11355
    OrganismiDrosophila willistoni (Fruit fly)
    Taxonomic identifieri7260 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007798: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0213366. Dwil\GK11355.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11241124cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363702Add
    BLAST
    Propeptidei1125 – 11273Removed in mature formBy similarityPRO_0000363703

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1124 – 11241Cysteine methyl esterBy similarity
    Lipidationi1124 – 11241S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Protein-protein interaction databases

    STRINGi7260.FBpp0240498.

    Structurei

    3D structure databases

    ProteinModelPortaliB4NAL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini255 – 407153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini439 – 624186GAF 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG270709.
    InParanoidiB4NAL6.
    KOiK13763.
    OMAiQVIRINE.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB4NAL6.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4NAL6-1 [UniParc]FASTAAdd to Basket

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    MTDVSAAAGG ATAEPPTATM SPTSVEPLTN GAKKSAMATT TETQTAAAAA     50
    AATTTPAATT TVTVTAAATT EASTSNQVKL ARVENVLGST STSSPANETK 100
    PKSLPDGGNA SVAPASSSSN SISTQTLIQS QSQPHAKTNK STTVASQQDV 150
    DEVARLFEEK PEAFEKWLTE RAPPEALSRL HEFIESRKPP KRPSVTSDLF 200
    QQWMASSPTV QQKSPGRSLS NSSASSLPEC RRHLMDLDEG ELFMELIRDV 250
    ANELDIDVLC HKILVNVGLL THADRGSLFL AKGTANNKYL VAKLFDVTQK 300
    TALKDAVTRA STEEIIIPFG IGIAGMVAQT KQMINIKEAY KDARFNCEID 350
    LKTGYKTNAI LCMPICNYEG DIIGVAQIIN KTNGCMEFDE HDVEIFRRYL 400
    TFCGIGIQNA QLFEMSVQEY RRNQILLNLA RSIFEEQNNL ECLVTKIMTE 450
    ARELLKCERC SVFLVDLDCC EASHLEKIIE KPNQLEQRPS RAIKSADSFE 500
    EKKLRNRFTV LFELGGEYQA ANVSRPSISE LSHSTLAQIA QFVATTGQTV 550
    NICDVNEWVR EHNHQIRTES EIDSTQAILC MPIVNAQKTV IGVAQLINKA 600
    NGVPFTESDA SIFEAFAIFC GLGIHNTQMY ENACKLMAKQ KVALECLSYH 650
    ATANQDQTEK LTQDVVAEAE SYNLYSFTFT DFDLVDDDTC RAVLRMFMQC 700
    NLVSQFQIPY DVLCRWVLSV RKNYRPVKYH NWRHALNVAQ TMFAMLKTGK 750
    MERFMTDLEI LGLLVACLCH DLDHRGTNNA FQTKTESPLA ILYTTSTMEH 800
    HHFDQCVMIL NSEGNNIFQA LSPEDYRSVM KTVESAILST DLAMYFKKRN 850
    AFLELVENGE FDWQGEEKKD LLCGMMMTAC DVSAIAKPWE VQHRVAKLVA 900
    DEFFDQGDLE KLQLNTQPVA MMDRERKDEL PKMQVGFIDV ICLPLYRVLC 950
    DTFPWITPLY EGTLENRRNW QDLAEKVEMG LTWIDHDTID KPVEEFAGCA 1000
    DEDIKDIEFT VQTLNCNQQS QETDAHTTPE HHRSGSRLSM KKTGALGKAV 1050
    RSKLSKTLYN SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPHGGSVGR 1100
    MSASSSTSSA GTVVDKTKKR SKLCALL 1127
    Length:1,127
    Mass (Da):125,223
    Last modified:September 23, 2008 - v1
    Checksum:i32473E517D9B55C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH964232 Genomic DNA. Translation: EDW80830.1.
    RefSeqiXP_002069844.1. XM_002069808.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0242006; FBpp0240498; FBgn0213366.
    GeneIDi6647390.
    KEGGidwi:Dwil_GK11355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH964232 Genomic DNA. Translation: EDW80830.1 .
    RefSeqi XP_002069844.1. XM_002069808.1.

    3D structure databases

    ProteinModelPortali B4NAL6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7260.FBpp0240498.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0242006 ; FBpp0240498 ; FBgn0213366 .
    GeneIDi 6647390.
    KEGGi dwi:Dwil_GK11355.

    Organism-specific databases

    FlyBasei FBgn0213366. Dwil\GK11355.

    Phylogenomic databases

    eggNOGi NOG270709.
    InParanoidi B4NAL6.
    KOi K13763.
    OMAi QVIRINE.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B4NAL6.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14030-0811.24Imported.

    Entry informationi

    Entry nameiPDE6_DROWI
    AccessioniPrimary (citable) accession number: B4NAL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3