SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4NAL6

- PDE6_DROWI

UniProt

B4NAL6 - PDE6_DROWI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene
Pde6, GK11355
Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei730 – 7301Proton donor By similarity
Metal bindingi734 – 7341Divalent metal cation 1 By similarity
Metal bindingi770 – 7701Divalent metal cation 1 By similarity
Metal bindingi771 – 7711Divalent metal cation 1 By similarity
Metal bindingi771 – 7711Divalent metal cation 2 By similarity
Metal bindingi881 – 8811Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GK11355
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0213366. Dwil\GK11355.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11241124cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarityPRO_0000363702Add
BLAST
Propeptidei1125 – 11273Removed in mature form By similarityBy similarityPRO_0000363703

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1124 – 11241Cysteine methyl ester By similarityBy similarity
Lipidationi1124 – 11241S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Protein-protein interaction databases

STRINGi7260.FBpp0240498.

Structurei

3D structure databases

ProteinModelPortaliB4NAL6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 407153GAF 1Add
BLAST
Domaini439 – 624186GAF 2Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiB4NAL6.
KOiK13763.
OMAiQVIRINE.
OrthoDBiEOG7RRF69.
PhylomeDBiB4NAL6.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4NAL6-1 [UniParc]FASTAAdd to Basket

« Hide

MTDVSAAAGG ATAEPPTATM SPTSVEPLTN GAKKSAMATT TETQTAAAAA     50
AATTTPAATT TVTVTAAATT EASTSNQVKL ARVENVLGST STSSPANETK 100
PKSLPDGGNA SVAPASSSSN SISTQTLIQS QSQPHAKTNK STTVASQQDV 150
DEVARLFEEK PEAFEKWLTE RAPPEALSRL HEFIESRKPP KRPSVTSDLF 200
QQWMASSPTV QQKSPGRSLS NSSASSLPEC RRHLMDLDEG ELFMELIRDV 250
ANELDIDVLC HKILVNVGLL THADRGSLFL AKGTANNKYL VAKLFDVTQK 300
TALKDAVTRA STEEIIIPFG IGIAGMVAQT KQMINIKEAY KDARFNCEID 350
LKTGYKTNAI LCMPICNYEG DIIGVAQIIN KTNGCMEFDE HDVEIFRRYL 400
TFCGIGIQNA QLFEMSVQEY RRNQILLNLA RSIFEEQNNL ECLVTKIMTE 450
ARELLKCERC SVFLVDLDCC EASHLEKIIE KPNQLEQRPS RAIKSADSFE 500
EKKLRNRFTV LFELGGEYQA ANVSRPSISE LSHSTLAQIA QFVATTGQTV 550
NICDVNEWVR EHNHQIRTES EIDSTQAILC MPIVNAQKTV IGVAQLINKA 600
NGVPFTESDA SIFEAFAIFC GLGIHNTQMY ENACKLMAKQ KVALECLSYH 650
ATANQDQTEK LTQDVVAEAE SYNLYSFTFT DFDLVDDDTC RAVLRMFMQC 700
NLVSQFQIPY DVLCRWVLSV RKNYRPVKYH NWRHALNVAQ TMFAMLKTGK 750
MERFMTDLEI LGLLVACLCH DLDHRGTNNA FQTKTESPLA ILYTTSTMEH 800
HHFDQCVMIL NSEGNNIFQA LSPEDYRSVM KTVESAILST DLAMYFKKRN 850
AFLELVENGE FDWQGEEKKD LLCGMMMTAC DVSAIAKPWE VQHRVAKLVA 900
DEFFDQGDLE KLQLNTQPVA MMDRERKDEL PKMQVGFIDV ICLPLYRVLC 950
DTFPWITPLY EGTLENRRNW QDLAEKVEMG LTWIDHDTID KPVEEFAGCA 1000
DEDIKDIEFT VQTLNCNQQS QETDAHTTPE HHRSGSRLSM KKTGALGKAV 1050
RSKLSKTLYN SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPHGGSVGR 1100
MSASSSTSSA GTVVDKTKKR SKLCALL 1127
Length:1,127
Mass (Da):125,223
Last modified:September 23, 2008 - v1
Checksum:i32473E517D9B55C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH964232 Genomic DNA. Translation: EDW80830.1.
RefSeqiXP_002069844.1. XM_002069808.1.

Genome annotation databases

EnsemblMetazoaiFBtr0242006; FBpp0240498; FBgn0213366.
GeneIDi6647390.
KEGGidwi:Dwil_GK11355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH964232 Genomic DNA. Translation: EDW80830.1 .
RefSeqi XP_002069844.1. XM_002069808.1.

3D structure databases

ProteinModelPortali B4NAL6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0240498.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0242006 ; FBpp0240498 ; FBgn0213366 .
GeneIDi 6647390.
KEGGi dwi:Dwil_GK11355.

Organism-specific databases

FlyBasei FBgn0213366. Dwil\GK11355.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi B4NAL6.
KOi K13763.
OMAi QVIRINE.
OrthoDBi EOG7RRF69.
PhylomeDBi B4NAL6.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24.

Entry informationi

Entry nameiPDE6_DROWI
AccessioniPrimary (citable) accession number: B4NAL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi