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B4NAL6

- PDE6_DROWI

UniProt

B4NAL6 - PDE6_DROWI

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei730 – 7301Proton donorBy similarity
Metal bindingi734 – 7341Divalent metal cation 1By similarity
Metal bindingi770 – 7701Divalent metal cation 1By similarity
Metal bindingi771 – 7711Divalent metal cation 1By similarity
Metal bindingi771 – 7711Divalent metal cation 2By similarity
Metal bindingi881 – 8811Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GK11355
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0213366. Dwil\GK11355.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11241124cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363702Add
BLAST
Propeptidei1125 – 11273Removed in mature formBy similarityPRO_0000363703

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1124 – 11241Cysteine methyl esterBy similarity
Lipidationi1124 – 11241S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Protein-protein interaction databases

STRINGi7260.FBpp0240498.

Structurei

3D structure databases

ProteinModelPortaliB4NAL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 407153GAF 1Sequence AnalysisAdd
BLAST
Domaini439 – 624186GAF 2Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiB4NAL6.
KOiK13763.
OMAiQVIRINE.
OrthoDBiEOG7RRF69.
PhylomeDBiB4NAL6.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4NAL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVSAAAGG ATAEPPTATM SPTSVEPLTN GAKKSAMATT TETQTAAAAA
60 70 80 90 100
AATTTPAATT TVTVTAAATT EASTSNQVKL ARVENVLGST STSSPANETK
110 120 130 140 150
PKSLPDGGNA SVAPASSSSN SISTQTLIQS QSQPHAKTNK STTVASQQDV
160 170 180 190 200
DEVARLFEEK PEAFEKWLTE RAPPEALSRL HEFIESRKPP KRPSVTSDLF
210 220 230 240 250
QQWMASSPTV QQKSPGRSLS NSSASSLPEC RRHLMDLDEG ELFMELIRDV
260 270 280 290 300
ANELDIDVLC HKILVNVGLL THADRGSLFL AKGTANNKYL VAKLFDVTQK
310 320 330 340 350
TALKDAVTRA STEEIIIPFG IGIAGMVAQT KQMINIKEAY KDARFNCEID
360 370 380 390 400
LKTGYKTNAI LCMPICNYEG DIIGVAQIIN KTNGCMEFDE HDVEIFRRYL
410 420 430 440 450
TFCGIGIQNA QLFEMSVQEY RRNQILLNLA RSIFEEQNNL ECLVTKIMTE
460 470 480 490 500
ARELLKCERC SVFLVDLDCC EASHLEKIIE KPNQLEQRPS RAIKSADSFE
510 520 530 540 550
EKKLRNRFTV LFELGGEYQA ANVSRPSISE LSHSTLAQIA QFVATTGQTV
560 570 580 590 600
NICDVNEWVR EHNHQIRTES EIDSTQAILC MPIVNAQKTV IGVAQLINKA
610 620 630 640 650
NGVPFTESDA SIFEAFAIFC GLGIHNTQMY ENACKLMAKQ KVALECLSYH
660 670 680 690 700
ATANQDQTEK LTQDVVAEAE SYNLYSFTFT DFDLVDDDTC RAVLRMFMQC
710 720 730 740 750
NLVSQFQIPY DVLCRWVLSV RKNYRPVKYH NWRHALNVAQ TMFAMLKTGK
760 770 780 790 800
MERFMTDLEI LGLLVACLCH DLDHRGTNNA FQTKTESPLA ILYTTSTMEH
810 820 830 840 850
HHFDQCVMIL NSEGNNIFQA LSPEDYRSVM KTVESAILST DLAMYFKKRN
860 870 880 890 900
AFLELVENGE FDWQGEEKKD LLCGMMMTAC DVSAIAKPWE VQHRVAKLVA
910 920 930 940 950
DEFFDQGDLE KLQLNTQPVA MMDRERKDEL PKMQVGFIDV ICLPLYRVLC
960 970 980 990 1000
DTFPWITPLY EGTLENRRNW QDLAEKVEMG LTWIDHDTID KPVEEFAGCA
1010 1020 1030 1040 1050
DEDIKDIEFT VQTLNCNQQS QETDAHTTPE HHRSGSRLSM KKTGALGKAV
1060 1070 1080 1090 1100
RSKLSKTLYN SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPHGGSVGR
1110 1120
MSASSSTSSA GTVVDKTKKR SKLCALL
Length:1,127
Mass (Da):125,223
Last modified:September 23, 2008 - v1
Checksum:i32473E517D9B55C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH964232 Genomic DNA. Translation: EDW80830.1.
RefSeqiXP_002069844.1. XM_002069808.1.

Genome annotation databases

EnsemblMetazoaiFBtr0242006; FBpp0240498; FBgn0213366.
GeneIDi6647390.
KEGGidwi:Dwil_GK11355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH964232 Genomic DNA. Translation: EDW80830.1 .
RefSeqi XP_002069844.1. XM_002069808.1.

3D structure databases

ProteinModelPortali B4NAL6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0240498.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0242006 ; FBpp0240498 ; FBgn0213366 .
GeneIDi 6647390.
KEGGi dwi:Dwil_GK11355.

Organism-specific databases

FlyBasei FBgn0213366. Dwil\GK11355.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi B4NAL6.
KOi K13763.
OMAi QVIRINE.
OrthoDBi EOG7RRF69.
PhylomeDBi B4NAL6.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiPDE6_DROWI
AccessioniPrimary (citable) accession number: B4NAL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3