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Protein

Hexokinase

Gene

Dwil\GK19144

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Dwil\GK19144Imported
ORF Names:Dwil_GK19144Imported, GK19144Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0221142. Dwil\GK19144.

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0248287.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiB4N456.
KOiK00844.
OMAiFIAECLS.
OrthoDBiEOG7S21X5.
PhylomeDBiB4N456.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4N456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSITNSTN ITSQTKYKFP EAHELCKEFV LSKKVMNEVI ERLTKEIKLG
60 70 80 90 100
LAKATHDKAT VKCFVTYVQD FPSGQERGKY LALDLGGTNF RVLMIELKSQ
110 120 130 140 150
TDVKIISKSF GISKELMTGP GQMLFDFIAE CLSKFCTEHN VDKKKEIPLG
160 170 180 190 200
FTFSFPLMQQ GLDRGILKVW TKGFICSGVV GQDVVQLLDE AIQRRNEIKI
210 220 230 240 250
KIVAIINDTV GTLMACAFYK CNCRIGLIVG TGTNACYVEK TQNAEMFEAN
260 270 280 290 300
HERTPGGKEH MIINSEWGAF GDNGVIDFLR TPFDKQVDEG SHNPGRQIYE
310 320 330 340 350
KCISGLFLGE LVRLILVDLM QKGAIFANQE SHSIQEKGKF LTRFVSEIET
360 370 380 390 400
DISGAFDYTD CVLNEIGIRN ASDKDKACLR YICQAVSTRA AQLTACGLVC
410 420 430 440 450
LINKMDVKDV AIAIDGSVYR HHPRFHDMLY INMKRLLQKD IEFQLILSED
460 470
GSGRGAALIA AAATNSKMNS K
Length:471
Mass (Da):52,558
Last modified:September 22, 2008 - v1
Checksum:iDA00F3165FB70569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964095 Genomic DNA. Translation: EDW78930.1.
RefSeqiXP_002067944.1. XM_002067908.1.

Genome annotation databases

EnsemblMetazoaiFBtr0249795; FBpp0248287; FBgn0221142.
GeneIDi6645577.
KEGGidwi:Dwil_GK19144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH964095 Genomic DNA. Translation: EDW78930.1.
RefSeqiXP_002067944.1. XM_002067908.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0248287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0249795; FBpp0248287; FBgn0221142.
GeneIDi6645577.
KEGGidwi:Dwil_GK19144.

Organism-specific databases

FlyBaseiFBgn0221142. Dwil\GK19144.

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiB4N456.
KOiK00844.
OMAiFIAECLS.
OrthoDBiEOG7S21X5.
PhylomeDBiB4N456.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiB4N456_DROWI
AccessioniPrimary (citable) accession number: B4N456
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2008
Last sequence update: September 22, 2008
Last modified: March 31, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.