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B4N278

- TRMB_DROWI

UniProt

B4N278 - TRMB_DROWI

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

GK16167

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei152 – 1521S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei155 – 1551UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:GK16167
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0218169. Dwil\GK16167.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251tRNA (guanine-N(7)-)-methyltransferasePRO_0000370577Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0245310.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 962S-adenosyl-L-methionine bindingUniRule annotation
Regioni132 – 1332S-adenosyl-L-methionine bindingUniRule annotation
Regioni230 – 2323S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
InParanoidiB4N278.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG7PS1GC.
PhylomeDBiB4N278.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4N278 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTTSQEQGH DALTATSAVT GLPQKRFYRQ RAHSNPIADH SFDYPARPED
60 70 80 90 100
VDWSALYPNI QPDQQVEFAD IGCGYGGFLV TLGEMFPQKL SIGMEIRVKV
110 120 130 140 150
SDYVVDRIAA LRLKSGKLNG DAYKNIACIR TNAMKYLPNY FRKGQLEKMF
160 170 180 190 200
FLYPDPHFKR AKHKWRIINQ ALLSEYAYVL RQGGLVYTMT DVEDLHQWIV
210 220 230 240 250
SHMNQHPLYE RISPEDESQD PITPKLYQSS EEGAKVVRNK GDHFLAIFRR

I
Length:251
Mass (Da):28,902
Last modified:September 23, 2008 - v1
Checksum:i08997CB61ADD14D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78467.1.
RefSeqiXP_002067481.1. XM_002067445.1.

Genome annotation databases

EnsemblMetazoaiFBtr0246818; FBpp0245310; FBgn0218169.
GeneIDi6644754.
KEGGidwi:Dwil_GK16167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78467.1 .
RefSeqi XP_002067481.1. XM_002067445.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0245310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0246818 ; FBpp0245310 ; FBgn0218169 .
GeneIDi 6644754.
KEGGi dwi:Dwil_GK16167.

Organism-specific databases

FlyBasei FBgn0218169. Dwil\GK16167.

Phylogenomic databases

eggNOGi COG0220.
InParanoidi B4N278.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG7PS1GC.
PhylomeDBi B4N278.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24.

Entry informationi

Entry nameiTRMB_DROWI
AccessioniPrimary (citable) accession number: B4N278
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3