Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase

Gene

Dwil\GK16179

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:Dwil\GK16179Imported
ORF Names:Dwil_GK16179Imported, GK16179Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0218181. Dwil\GK16179.

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0245322.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 373SETInterPro annotationAdd BLAST112

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
InParanoidiB4N249.
KOiK11429.
OrthoDBiEOG091G0IUY.

Family and domain databases

InterProiView protein in InterPro
IPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Fragment.

B4N249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGSNHTRR GETGSRYTSN TTTTTAITNN NNTNGGNTNT NNNRSNSTST
60 70 80 90 100
STAAALLSSM SHKSHNAVHA PTANSNHHHN HHLQYHQQHN NHQQQQQQQH
110 120 130 140 150
HLHSHYQTQQ QHQQHSHHQT NGSSSGGGGS GGGVIGTLNG CNGSGSASAV
160 170 180 190 200
SRISQSTGMS PRELSENDDL ATSLILDPHL GFQTHKMNIR FRPLKVDTQQ
210 220 230 240 250
LKTIVDDFIH TQNYDVAIQK IYDGPWIPRH LKNKNKIATK RLHDHIVRYL
260 270 280 290 300
RVFDKDSGFA IEACYRYSLE EQRGAKINST KRWSKNEKIE CLVGCIAELT
310 320 330 340 350
ESEEAALLHA GKNDFSVMYS CRKNCAQLWL GPAAYINHDC RANCKFLATG
360 370 380 390 400
RDTACVKVLR DIEVGEEITC FYGEDFFGDS NRYCECETCE RRGTGAFAGK
410 420 430 440 450
RNNDGRGGLD DVNGMGLLGG LSSGMGLVTV GGSTVVGGTT VGGGYRLRET
460 470 480 490 500
DNRINRIKSR ANSTNSTSNS NGSNTTNDSS NNESNPSISA AGGCTTGVVT
510 520 530 540 550
SGGATSSKES AIAAAGPGAV VAISNLVEKN NKTEQPVTNV VVSPLTMKEL
560 570 580 590 600
RQKGMTKYDA EMIMANNAYH HHHNHHHHHN NNHHHHHNHH LTGAEAVQQM
610 620 630 640 650
ANMQKPGTSN TAAAATAAAA SATSSSNTTN LTELNGSGRS STLRKSMRVN
660 670 680 690 700
STSSSISTAS TEDAVTTTTT AAAVVLVPRY KPAMAMAAAQ QQQQRQLRRS
710 720 730 740 750
ERQNNSSNKA TITNCNNNNN SRINSIANTN ASEMQQQQQQ QQHLEPAFKK
760 770 780 790 800
NLLAAATAAP TEAFLHKRSR RAAALAAAQH IHSDALNAYP AGAAGGASGG
810 820 830 840 850
GPASSILSSS STSSTVEPLL KTPERRLKLT LRMKRSPILD EVIELGTSLS
860 870 880 890 900
NDNRHLIARQ NGIISGSVGA AGPGGGSGGS SSAGTTGGGN YKSNLSSVGG
910 920 930 940 950
TAARATTIGG LVGGREKSLL KNDVEYNGNG GNCSATGNGI EYEILRMEGI
960 970 980 990 1000
SEHGNDDDDD DDDDFKRKKN KKQRNRRSSP ITVLNGGVAG ATSTTSSSSV
1010 1020 1030 1040 1050
YGTPQKKRLR LIFGNETHTI DIPPTATNST ACTTTTTTSN HNSRLSGGGA
1060 1070 1080 1090 1100
SGVDDLINSS GVSASDESFN ASYASSSQMT VNTSANSTSN SNNSSTSTTT
1110 1120 1130 1140 1150
SSAVPHAATT TSSTSGTGTS VNNLYNFPNG VATDNYYNYL GKYTAKGQQQ
1160 1170 1180 1190
GASSPGQGQA IAGAAAAAGA FLSLPKHTFG TCALMAPTGF ANLQQQQHH
Length:1,199
Mass (Da):126,742
Last modified:January 20, 2016 - v2
Checksum:i4BEC19710F214965
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1199Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963925 Genomic DNA. Translation: EDW78438.2.
RefSeqiXP_002067452.2. XM_002067416.2.

Genome annotation databases

EnsemblMetazoaiFBtr0246830; FBpp0245322; FBgn0218181.
GeneIDi6644812.
KEGGidwi:Dwil_GK16179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963925 Genomic DNA. Translation: EDW78438.2.
RefSeqiXP_002067452.2. XM_002067416.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0245322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0246830; FBpp0245322; FBgn0218181.
GeneIDi6644812.
KEGGidwi:Dwil_GK16179.

Organism-specific databases

FlyBaseiFBgn0218181. Dwil\GK16179.

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
InParanoidiB4N249.
KOiK11429.
OrthoDBiEOG091G0IUY.

Family and domain databases

InterProiView protein in InterPro
IPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4N249_DROWI
AccessioniPrimary (citable) accession number: B4N249
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: February 15, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.