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B4N208 (UBE2S_DROWI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene names
ORF Names:GK16201
OrganismDrosophila willistoni (Fruit fly) [Complete proteome]
Taxonomic identifier7260 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Ubiquitin-conjugating enzyme E2 S
PRO_0000390447

Sites

Active site981Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
B4N208 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 992A2D8448B06C4D

FASTA20823,431
        10         20         30         40         50         60 
MSSQYSNVEN LSPQTIRQVM RELQEMENTP PEGIKVLINE SDVTDIQALI DGPAGTPYAI 

        70         80         90        100        110        120 
GVFRVKLTLS KDFPQTPPKA YFLTKIFHPN VAANGEICVN TLKKDWKPDL GIKHILLTIK 

       130        140        150        160        170        180 
CLLIVPNPES ALNEEAGKML LERYDDYSQR ARMMTEIHAQ PAKCASTTSD AKDDDGPSTK 

       190        200 
KHAGLDKKLQ DKKKEKLLKE KKRMLKRL 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14030-0811.24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH963925 Genomic DNA. Translation: EDW78397.1.
RefSeqXP_002067411.1. XM_002067375.1.

3D structure databases

ProteinModelPortalB4N208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7260.FBpp0245344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0246852; FBpp0245344; FBgn0218203.
GeneID6644491.
KEGGdwi:Dwil_GK16201.

Organism-specific databases

FlyBaseFBgn0218203. Dwil\GK16201.

Phylogenomic databases

eggNOGCOG5078.
InParanoidB4N208.
KOK10583.
OMAPDLGIKH.
OrthoDBEOG73JKXD.
PhylomeDBB4N208.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2S_DROWI
AccessionPrimary (citable) accession number: B4N208
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase