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B4N208

- UBE2S_DROWI

UniProt

B4N208 - UBE2S_DROWI

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Protein
Ubiquitin-conjugating enzyme E2 S
Gene
GK16201
Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  2. exit from mitosis Source: UniProtKB
  3. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 S (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene namesi
ORF Names:GK16201
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0218203. Dwil\GK16201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Ubiquitin-conjugating enzyme E2 S
PRO_0000390447Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0245344.

Structurei

3D structure databases

ProteinModelPortaliB4N208.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
InParanoidiB4N208.
KOiK10583.
OMAiPDLGIKH.
OrthoDBiEOG73JKXD.
PhylomeDBiB4N208.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4N208-1 [UniParc]FASTAAdd to Basket

« Hide

MSSQYSNVEN LSPQTIRQVM RELQEMENTP PEGIKVLINE SDVTDIQALI    50
DGPAGTPYAI GVFRVKLTLS KDFPQTPPKA YFLTKIFHPN VAANGEICVN 100
TLKKDWKPDL GIKHILLTIK CLLIVPNPES ALNEEAGKML LERYDDYSQR 150
ARMMTEIHAQ PAKCASTTSD AKDDDGPSTK KHAGLDKKLQ DKKKEKLLKE 200
KKRMLKRL 208
Length:208
Mass (Da):23,431
Last modified:September 23, 2008 - v1
Checksum:i992A2D8448B06C4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78397.1.
RefSeqiXP_002067411.1. XM_002067375.1.

Genome annotation databases

EnsemblMetazoaiFBtr0246852; FBpp0245344; FBgn0218203.
GeneIDi6644491.
KEGGidwi:Dwil_GK16201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78397.1 .
RefSeqi XP_002067411.1. XM_002067375.1.

3D structure databases

ProteinModelPortali B4N208.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0245344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0246852 ; FBpp0245344 ; FBgn0218203 .
GeneIDi 6644491.
KEGGi dwi:Dwil_GK16201.

Organism-specific databases

FlyBasei FBgn0218203. Dwil\GK16201.

Phylogenomic databases

eggNOGi COG5078.
InParanoidi B4N208.
KOi K10583.
OMAi PDLGIKH.
OrthoDBi EOG73JKXD.
PhylomeDBi B4N208.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24.

Entry informationi

Entry nameiUBE2S_DROWI
AccessioniPrimary (citable) accession number: B4N208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi