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B4N1W9

- SWS_DROWI

UniProt

B4N1W9 - SWS_DROWI

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1000 – 10001By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 302128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi492 – 624133cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi613 – 740128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GK16217
    OrganismiDrosophila willistoni (Fruit fly)
    Taxonomic identifieri7260 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007798: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0218219. Dwil\GK16217.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14811481Neuropathy target esterase swsPRO_0000389228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei448 – 4481PhosphoserineBy similarity
    Modified residuei1214 – 12141PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Protein-protein interaction databases

    STRINGi7260.FBpp0245360.

    Structurei

    3D structure databases

    ProteinModelPortaliB4N1W9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14811426CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini967 – 1133167PatatinSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1424 – 14274Poly-GlnSequence Analysis

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    InParanoidiB4N1W9.
    KOiK14676.
    OMAiMACDRAR.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB4N1W9.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4N1W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLELLRAS ANGCYNTIFS DAWSQYVSQQ ITSSLYLYIA LGILTVLFVA     50
    WFIYFKRLAR LRLRDEIARS LNAVTSASGG DLRGLRFRKR DKMLFYGRRM 100
    LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLRRENMPL EMRTVEPPAE 150
    YLEETIEGSD RVPPDALYML QSIRIFGHFE KPVFLKLCKH TQVLELMAGD 200
    YLFKITDADD SVYIVQSGMI NVYISNADGS TLSLKTVRKG ESVTSLLSFI 250
    DVLSGNPSYY KTVTAKAMEK SVVIRLPMQA FEEVFRENPD VMIRVIQVIM 300
    IRLQRVLFTA LRNYLGLNAE LVQNHMRNKS ITISGHLNSQ SQSSQSMRQQ 350
    TTATATGGTS ATALGGQQLP AAVPSLPLQR QPPPPTIAPP LRHSREEHTL 400
    SGPNPNPNSG NNVQLPEVHG DAPNIDIYHQ QQHGGSTSTG NLSTRRGSLV 450
    QPSIGGGGGG STAQEGGCAA AGAPTIDMRL IQSSAVESLR KELGLPNEDA 500
    HIIEPFVEVR ELEPNVTLIT EGNADDVCIW FVMTGTLAVY QGVADATRSS 550
    TATTKSDKSD LLIHFVHPGE IVGGLAMLTG EASAYTIRSR NNSRVAYIRR 600
    AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR QCDYALDWIF LESGRAVYRQ 650
    DESSDSTYIV LSGRMRSVIT NPGGKKEIVG EYGKGDLVGI VEMITETSRT 700
    TTVMAVRDSE LAKLPEGLFN AIKLRYPIVV TKLISFLSHR FLGSMQTRGS 750
    TGAPGAPVEA NPVTHKYSTV ALVPITDEVP LTPFTYELYH SLCAIGPVLR 800
    LTSEVVRKQL GQNIFEAANE YRLTSWLAQQ EDRNIITLYQ CDNSLSPWTH 850
    RCMRQADVIL IVGLGDRSHL VGKFEREIDR LAMRTQKELV LLYPETTNAK 900
    PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS RVLLSEPNMH 950
    SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG IPIDMVGGVS 1000
    IGALMGALWC SERNITTVTQ KARQWSKKMT KWFLQLLDLT YPITSMFSGR 1050
    EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG SLWRYVRSSM 1100
    SLSGYMPPLC DPKDGHLLLD GGYVNNLPGH LWRYCRASMS IAGVFPPFCD 1150
    YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT DLTNYGDDLS 1200
    GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV KNSDYCEYIR 1250
    PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE SMAKAGRLGR FNQWFNKEPP 1300
    KRGNHASLNE YTFIDLAQIV CKLPETYAVN TAEIFSEDED CDGYISEPST 1350
    LNTDRRIQVP RAGNSLSLSE AEMDSDVEID FRSDSKKDKA TQSTPPAPGK 1400
    DNEDKTDAVD RIPLLTLERP LTDQQQQHSD ETDEQETPRA MKDGTNTMTT 1450
    QTTSPTTDAG SEWAGSESEL EKENKNVNTK N 1481
    Length:1,481
    Mass (Da):165,348
    Last modified:September 23, 2008 - v1
    Checksum:iFF336B974557F11A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH963925 Genomic DNA. Translation: EDW78358.1.
    RefSeqiXP_002067372.1. XM_002067336.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0246868; FBpp0245360; FBgn0218219.
    GeneIDi6644825.
    KEGGidwi:Dwil_GK16217.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH963925 Genomic DNA. Translation: EDW78358.1 .
    RefSeqi XP_002067372.1. XM_002067336.1.

    3D structure databases

    ProteinModelPortali B4N1W9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7260.FBpp0245360.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0246868 ; FBpp0245360 ; FBgn0218219 .
    GeneIDi 6644825.
    KEGGi dwi:Dwil_GK16217.

    Organism-specific databases

    FlyBasei FBgn0218219. Dwil\GK16217.

    Phylogenomic databases

    eggNOGi COG0664.
    InParanoidi B4N1W9.
    KOi K14676.
    OMAi MACDRAR.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B4N1W9.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14030-0811.24Imported.

    Entry informationi

    Entry nameiSWS_DROWI
    AccessioniPrimary (citable) accession number: B4N1W9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3