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B4N1W9

- SWS_DROWI

UniProt

B4N1W9 - SWS_DROWI

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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1000 – 10001By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 302128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi492 – 624133cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi613 – 740128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GK16217
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0218219. Dwil\GK16217.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14811481Neuropathy target esterase swsPRO_0000389228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei448 – 4481PhosphoserineBy similarity
Modified residuei1214 – 12141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7260.FBpp0245360.

Structurei

3D structure databases

ProteinModelPortaliB4N1W9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence AnalysisAdd
BLAST
Topological domaini56 – 14811426CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini967 – 1133167PatatinSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1424 – 14274Poly-GlnSequence Analysis

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB4N1W9.
KOiK14676.
OMAiMACDRAR.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4N1W9.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4N1W9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLELLRAS ANGCYNTIFS DAWSQYVSQQ ITSSLYLYIA LGILTVLFVA
60 70 80 90 100
WFIYFKRLAR LRLRDEIARS LNAVTSASGG DLRGLRFRKR DKMLFYGRRM
110 120 130 140 150
LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLRRENMPL EMRTVEPPAE
160 170 180 190 200
YLEETIEGSD RVPPDALYML QSIRIFGHFE KPVFLKLCKH TQVLELMAGD
210 220 230 240 250
YLFKITDADD SVYIVQSGMI NVYISNADGS TLSLKTVRKG ESVTSLLSFI
260 270 280 290 300
DVLSGNPSYY KTVTAKAMEK SVVIRLPMQA FEEVFRENPD VMIRVIQVIM
310 320 330 340 350
IRLQRVLFTA LRNYLGLNAE LVQNHMRNKS ITISGHLNSQ SQSSQSMRQQ
360 370 380 390 400
TTATATGGTS ATALGGQQLP AAVPSLPLQR QPPPPTIAPP LRHSREEHTL
410 420 430 440 450
SGPNPNPNSG NNVQLPEVHG DAPNIDIYHQ QQHGGSTSTG NLSTRRGSLV
460 470 480 490 500
QPSIGGGGGG STAQEGGCAA AGAPTIDMRL IQSSAVESLR KELGLPNEDA
510 520 530 540 550
HIIEPFVEVR ELEPNVTLIT EGNADDVCIW FVMTGTLAVY QGVADATRSS
560 570 580 590 600
TATTKSDKSD LLIHFVHPGE IVGGLAMLTG EASAYTIRSR NNSRVAYIRR
610 620 630 640 650
AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR QCDYALDWIF LESGRAVYRQ
660 670 680 690 700
DESSDSTYIV LSGRMRSVIT NPGGKKEIVG EYGKGDLVGI VEMITETSRT
710 720 730 740 750
TTVMAVRDSE LAKLPEGLFN AIKLRYPIVV TKLISFLSHR FLGSMQTRGS
760 770 780 790 800
TGAPGAPVEA NPVTHKYSTV ALVPITDEVP LTPFTYELYH SLCAIGPVLR
810 820 830 840 850
LTSEVVRKQL GQNIFEAANE YRLTSWLAQQ EDRNIITLYQ CDNSLSPWTH
860 870 880 890 900
RCMRQADVIL IVGLGDRSHL VGKFEREIDR LAMRTQKELV LLYPETTNAK
910 920 930 940 950
PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS RVLLSEPNMH
960 970 980 990 1000
SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG IPIDMVGGVS
1010 1020 1030 1040 1050
IGALMGALWC SERNITTVTQ KARQWSKKMT KWFLQLLDLT YPITSMFSGR
1060 1070 1080 1090 1100
EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG SLWRYVRSSM
1110 1120 1130 1140 1150
SLSGYMPPLC DPKDGHLLLD GGYVNNLPGH LWRYCRASMS IAGVFPPFCD
1160 1170 1180 1190 1200
YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT DLTNYGDDLS
1210 1220 1230 1240 1250
GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV KNSDYCEYIR
1260 1270 1280 1290 1300
PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE SMAKAGRLGR FNQWFNKEPP
1310 1320 1330 1340 1350
KRGNHASLNE YTFIDLAQIV CKLPETYAVN TAEIFSEDED CDGYISEPST
1360 1370 1380 1390 1400
LNTDRRIQVP RAGNSLSLSE AEMDSDVEID FRSDSKKDKA TQSTPPAPGK
1410 1420 1430 1440 1450
DNEDKTDAVD RIPLLTLERP LTDQQQQHSD ETDEQETPRA MKDGTNTMTT
1460 1470 1480
QTTSPTTDAG SEWAGSESEL EKENKNVNTK N
Length:1,481
Mass (Da):165,348
Last modified:September 23, 2008 - v1
Checksum:iFF336B974557F11A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78358.1.
RefSeqiXP_002067372.1. XM_002067336.1.

Genome annotation databases

EnsemblMetazoaiFBtr0246868; FBpp0245360; FBgn0218219.
GeneIDi6644825.
KEGGidwi:Dwil_GK16217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78358.1 .
RefSeqi XP_002067372.1. XM_002067336.1.

3D structure databases

ProteinModelPortali B4N1W9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0245360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0246868 ; FBpp0245360 ; FBgn0218219 .
GeneIDi 6644825.
KEGGi dwi:Dwil_GK16217.

Organism-specific databases

FlyBasei FBgn0218219. Dwil\GK16217.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B4N1W9.
KOi K14676.
OMAi MACDRAR.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4N1W9.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiSWS_DROWI
AccessioniPrimary (citable) accession number: B4N1W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3