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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1000NucleophilePROSITE-ProRule annotation1
Active sitei1120Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 302cNMP 1Sequence analysisAdd BLAST128
Nucleotide bindingi492 – 624cNMP 2Sequence analysisAdd BLAST133
Nucleotide bindingi613 – 740cNMP 3Sequence analysisAdd BLAST128

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GK16217
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0218219. Dwil\GK16217.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Sws tethers Pka-C3 to the membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34LumenalSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 1481CytoplasmicSequence analysisAdd BLAST1426

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003892281 – 1481Neuropathy target esterase swsAdd BLAST1481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei448PhosphoserineBy similarity1
Modified residuei1214PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7260.FBpp0245360.

Structurei

3D structure databases

ProteinModelPortaliB4N1W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini967 – 1133PNPLAPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi971 – 976GXGXXGPROSITE-ProRule annotation6
Motifi998 – 1002GXSXGPROSITE-ProRule annotation5
Motifi1120 – 1122DGA/GPROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1424 – 1427Poly-GlnSequence analysis4

Sequence similaritiesi

Belongs to the NTE family.Sequence analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 PNPLA (patatin-like phospholipase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
InParanoidiB4N1W9.
KOiK14676.
OMAiCAQVGIL.
OrthoDBiEOG091G00XM.
PhylomeDBiB4N1W9.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4N1W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLELLRAS ANGCYNTIFS DAWSQYVSQQ ITSSLYLYIA LGILTVLFVA
60 70 80 90 100
WFIYFKRLAR LRLRDEIARS LNAVTSASGG DLRGLRFRKR DKMLFYGRRM
110 120 130 140 150
LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLRRENMPL EMRTVEPPAE
160 170 180 190 200
YLEETIEGSD RVPPDALYML QSIRIFGHFE KPVFLKLCKH TQVLELMAGD
210 220 230 240 250
YLFKITDADD SVYIVQSGMI NVYISNADGS TLSLKTVRKG ESVTSLLSFI
260 270 280 290 300
DVLSGNPSYY KTVTAKAMEK SVVIRLPMQA FEEVFRENPD VMIRVIQVIM
310 320 330 340 350
IRLQRVLFTA LRNYLGLNAE LVQNHMRNKS ITISGHLNSQ SQSSQSMRQQ
360 370 380 390 400
TTATATGGTS ATALGGQQLP AAVPSLPLQR QPPPPTIAPP LRHSREEHTL
410 420 430 440 450
SGPNPNPNSG NNVQLPEVHG DAPNIDIYHQ QQHGGSTSTG NLSTRRGSLV
460 470 480 490 500
QPSIGGGGGG STAQEGGCAA AGAPTIDMRL IQSSAVESLR KELGLPNEDA
510 520 530 540 550
HIIEPFVEVR ELEPNVTLIT EGNADDVCIW FVMTGTLAVY QGVADATRSS
560 570 580 590 600
TATTKSDKSD LLIHFVHPGE IVGGLAMLTG EASAYTIRSR NNSRVAYIRR
610 620 630 640 650
AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR QCDYALDWIF LESGRAVYRQ
660 670 680 690 700
DESSDSTYIV LSGRMRSVIT NPGGKKEIVG EYGKGDLVGI VEMITETSRT
710 720 730 740 750
TTVMAVRDSE LAKLPEGLFN AIKLRYPIVV TKLISFLSHR FLGSMQTRGS
760 770 780 790 800
TGAPGAPVEA NPVTHKYSTV ALVPITDEVP LTPFTYELYH SLCAIGPVLR
810 820 830 840 850
LTSEVVRKQL GQNIFEAANE YRLTSWLAQQ EDRNIITLYQ CDNSLSPWTH
860 870 880 890 900
RCMRQADVIL IVGLGDRSHL VGKFEREIDR LAMRTQKELV LLYPETTNAK
910 920 930 940 950
PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS RVLLSEPNMH
960 970 980 990 1000
SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG IPIDMVGGVS
1010 1020 1030 1040 1050
IGALMGALWC SERNITTVTQ KARQWSKKMT KWFLQLLDLT YPITSMFSGR
1060 1070 1080 1090 1100
EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG SLWRYVRSSM
1110 1120 1130 1140 1150
SLSGYMPPLC DPKDGHLLLD GGYVNNLPGH LWRYCRASMS IAGVFPPFCD
1160 1170 1180 1190 1200
YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT DLTNYGDDLS
1210 1220 1230 1240 1250
GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV KNSDYCEYIR
1260 1270 1280 1290 1300
PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE SMAKAGRLGR FNQWFNKEPP
1310 1320 1330 1340 1350
KRGNHASLNE YTFIDLAQIV CKLPETYAVN TAEIFSEDED CDGYISEPST
1360 1370 1380 1390 1400
LNTDRRIQVP RAGNSLSLSE AEMDSDVEID FRSDSKKDKA TQSTPPAPGK
1410 1420 1430 1440 1450
DNEDKTDAVD RIPLLTLERP LTDQQQQHSD ETDEQETPRA MKDGTNTMTT
1460 1470 1480
QTTSPTTDAG SEWAGSESEL EKENKNVNTK N
Length:1,481
Mass (Da):165,348
Last modified:September 23, 2008 - v1
Checksum:iFF336B974557F11A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963925 Genomic DNA. Translation: EDW78358.1.
RefSeqiXP_002067372.2. XM_002067336.2.

Genome annotation databases

EnsemblMetazoaiFBtr0246868; FBpp0245360; FBgn0218219.
GeneIDi6644825.
KEGGidwi:Dwil_GK16217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963925 Genomic DNA. Translation: EDW78358.1.
RefSeqiXP_002067372.2. XM_002067336.2.

3D structure databases

ProteinModelPortaliB4N1W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0245360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0246868; FBpp0245360; FBgn0218219.
GeneIDi6644825.
KEGGidwi:Dwil_GK16217.

Organism-specific databases

FlyBaseiFBgn0218219. Dwil\GK16217.

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
InParanoidiB4N1W9.
KOiK14676.
OMAiCAQVGIL.
OrthoDBiEOG091G00XM.
PhylomeDBiB4N1W9.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWS_DROWI
AccessioniPrimary (citable) accession number: B4N1W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.