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B4N1W9

- SWS_DROWI

UniProt

B4N1W9 - SWS_DROWI

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Protein

Neuropathy target esterase sws

Gene
sws, GK16217
Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1000 – 10001 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 302128cNMP 1Add
BLAST
Nucleotide bindingi492 – 624133cNMP 2Add
BLAST
Nucleotide bindingi613 – 740128cNMP 3Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GK16217
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0218219. Dwil\GK16217.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Topological domaini56 – 14811426Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14811481Neuropathy target esterase swsPRO_0000389228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei448 – 4481Phosphoserine By similarityBy similarity
Modified residuei1214 – 12141Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Protein-protein interaction databases

STRINGi7260.FBpp0245360.

Structurei

3D structure databases

ProteinModelPortaliB4N1W9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini967 – 1133167PatatinAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1424 – 14274Poly-Gln

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB4N1W9.
KOiK14676.
OMAiMACDRAR.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4N1W9.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4N1W9-1 [UniParc]FASTAAdd to Basket

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MDVLELLRAS ANGCYNTIFS DAWSQYVSQQ ITSSLYLYIA LGILTVLFVA     50
WFIYFKRLAR LRLRDEIARS LNAVTSASGG DLRGLRFRKR DKMLFYGRRM 100
LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLRRENMPL EMRTVEPPAE 150
YLEETIEGSD RVPPDALYML QSIRIFGHFE KPVFLKLCKH TQVLELMAGD 200
YLFKITDADD SVYIVQSGMI NVYISNADGS TLSLKTVRKG ESVTSLLSFI 250
DVLSGNPSYY KTVTAKAMEK SVVIRLPMQA FEEVFRENPD VMIRVIQVIM 300
IRLQRVLFTA LRNYLGLNAE LVQNHMRNKS ITISGHLNSQ SQSSQSMRQQ 350
TTATATGGTS ATALGGQQLP AAVPSLPLQR QPPPPTIAPP LRHSREEHTL 400
SGPNPNPNSG NNVQLPEVHG DAPNIDIYHQ QQHGGSTSTG NLSTRRGSLV 450
QPSIGGGGGG STAQEGGCAA AGAPTIDMRL IQSSAVESLR KELGLPNEDA 500
HIIEPFVEVR ELEPNVTLIT EGNADDVCIW FVMTGTLAVY QGVADATRSS 550
TATTKSDKSD LLIHFVHPGE IVGGLAMLTG EASAYTIRSR NNSRVAYIRR 600
AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR QCDYALDWIF LESGRAVYRQ 650
DESSDSTYIV LSGRMRSVIT NPGGKKEIVG EYGKGDLVGI VEMITETSRT 700
TTVMAVRDSE LAKLPEGLFN AIKLRYPIVV TKLISFLSHR FLGSMQTRGS 750
TGAPGAPVEA NPVTHKYSTV ALVPITDEVP LTPFTYELYH SLCAIGPVLR 800
LTSEVVRKQL GQNIFEAANE YRLTSWLAQQ EDRNIITLYQ CDNSLSPWTH 850
RCMRQADVIL IVGLGDRSHL VGKFEREIDR LAMRTQKELV LLYPETTNAK 900
PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS RVLLSEPNMH 950
SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG IPIDMVGGVS 1000
IGALMGALWC SERNITTVTQ KARQWSKKMT KWFLQLLDLT YPITSMFSGR 1050
EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG SLWRYVRSSM 1100
SLSGYMPPLC DPKDGHLLLD GGYVNNLPGH LWRYCRASMS IAGVFPPFCD 1150
YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT DLTNYGDDLS 1200
GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV KNSDYCEYIR 1250
PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE SMAKAGRLGR FNQWFNKEPP 1300
KRGNHASLNE YTFIDLAQIV CKLPETYAVN TAEIFSEDED CDGYISEPST 1350
LNTDRRIQVP RAGNSLSLSE AEMDSDVEID FRSDSKKDKA TQSTPPAPGK 1400
DNEDKTDAVD RIPLLTLERP LTDQQQQHSD ETDEQETPRA MKDGTNTMTT 1450
QTTSPTTDAG SEWAGSESEL EKENKNVNTK N 1481
Length:1,481
Mass (Da):165,348
Last modified:September 23, 2008 - v1
Checksum:iFF336B974557F11A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78358.1.
RefSeqiXP_002067372.1. XM_002067336.1.

Genome annotation databases

EnsemblMetazoaiFBtr0246868; FBpp0245360; FBgn0218219.
GeneIDi6644825.
KEGGidwi:Dwil_GK16217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963925 Genomic DNA. Translation: EDW78358.1 .
RefSeqi XP_002067372.1. XM_002067336.1.

3D structure databases

ProteinModelPortali B4N1W9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0245360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0246868 ; FBpp0245360 ; FBgn0218219 .
GeneIDi 6644825.
KEGGi dwi:Dwil_GK16217.

Organism-specific databases

FlyBasei FBgn0218219. Dwil\GK16217.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B4N1W9.
KOi K14676.
OMAi MACDRAR.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4N1W9.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24.

Entry informationi

Entry nameiSWS_DROWI
AccessioniPrimary (citable) accession number: B4N1W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi