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B4N1W9 (SWS_DROWI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese
EC=3.1.1.5
Gene names
Name:sws
ORF Names:GK16217
OrganismDrosophila willistoni (Fruit fly) [Complete proteome]
Taxonomic identifier7260 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity. UniProtKB Q9U969

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. UniProtKB Q9U969

Subunit structure

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity. UniProtKB Q9U969

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Sws tethers Pka-C3 to the membrane By similarity. UniProtKB Q9U969

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14811481Neuropathy target esterase sws
PRO_0000389228

Regions

Topological domain1 – 3434Lumenal Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 14811426Cytoplasmic Potential
Domain967 – 1133167Patatin
Nucleotide binding175 – 302128cNMP 1
Nucleotide binding492 – 624133cNMP 2
Nucleotide binding613 – 740128cNMP 3
Compositional bias1424 – 14274Poly-Gln

Sites

Active site10001 By similarity UniProtKB Q9U969

Amino acid modifications

Modified residue4481Phosphoserine By similarity UniProtKB Q9U969
Modified residue12141Phosphoserine By similarity UniProtKB Q9U969

Sequences

Sequence LengthMass (Da)Tools
B4N1W9 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: FF336B974557F11A

FASTA1,481165,348
        10         20         30         40         50         60 
MDVLELLRAS ANGCYNTIFS DAWSQYVSQQ ITSSLYLYIA LGILTVLFVA WFIYFKRLAR 

        70         80         90        100        110        120 
LRLRDEIARS LNAVTSASGG DLRGLRFRKR DKMLFYGRRM LRKMKNVSGQ MYSSGKGYKR 

       130        140        150        160        170        180 
RAVMRFARRI LQLRRENMPL EMRTVEPPAE YLEETIEGSD RVPPDALYML QSIRIFGHFE 

       190        200        210        220        230        240 
KPVFLKLCKH TQVLELMAGD YLFKITDADD SVYIVQSGMI NVYISNADGS TLSLKTVRKG 

       250        260        270        280        290        300 
ESVTSLLSFI DVLSGNPSYY KTVTAKAMEK SVVIRLPMQA FEEVFRENPD VMIRVIQVIM 

       310        320        330        340        350        360 
IRLQRVLFTA LRNYLGLNAE LVQNHMRNKS ITISGHLNSQ SQSSQSMRQQ TTATATGGTS 

       370        380        390        400        410        420 
ATALGGQQLP AAVPSLPLQR QPPPPTIAPP LRHSREEHTL SGPNPNPNSG NNVQLPEVHG 

       430        440        450        460        470        480 
DAPNIDIYHQ QQHGGSTSTG NLSTRRGSLV QPSIGGGGGG STAQEGGCAA AGAPTIDMRL 

       490        500        510        520        530        540 
IQSSAVESLR KELGLPNEDA HIIEPFVEVR ELEPNVTLIT EGNADDVCIW FVMTGTLAVY 

       550        560        570        580        590        600 
QGVADATRSS TATTKSDKSD LLIHFVHPGE IVGGLAMLTG EASAYTIRSR NNSRVAYIRR 

       610        620        630        640        650        660 
AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR QCDYALDWIF LESGRAVYRQ DESSDSTYIV 

       670        680        690        700        710        720 
LSGRMRSVIT NPGGKKEIVG EYGKGDLVGI VEMITETSRT TTVMAVRDSE LAKLPEGLFN 

       730        740        750        760        770        780 
AIKLRYPIVV TKLISFLSHR FLGSMQTRGS TGAPGAPVEA NPVTHKYSTV ALVPITDEVP 

       790        800        810        820        830        840 
LTPFTYELYH SLCAIGPVLR LTSEVVRKQL GQNIFEAANE YRLTSWLAQQ EDRNIITLYQ 

       850        860        870        880        890        900 
CDNSLSPWTH RCMRQADVIL IVGLGDRSHL VGKFEREIDR LAMRTQKELV LLYPETTNAK 

       910        920        930        940        950        960 
PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS RVLLSEPNMH SDFSRLARWL 

       970        980        990       1000       1010       1020 
TGNSIGLVLG GGGARGAAHI GMLKAIQEAG IPIDMVGGVS IGALMGALWC SERNITTVTQ 

      1030       1040       1050       1060       1070       1080 
KARQWSKKMT KWFLQLLDLT YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT 

      1090       1100       1110       1120       1130       1140 
ASCHRIHTNG SLWRYVRSSM SLSGYMPPLC DPKDGHLLLD GGYVNNLPGH LWRYCRASMS 

      1150       1160       1170       1180       1190       1200 
IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT DLTNYGDDLS 

      1210       1220       1230       1240       1250       1260 
GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV KNSDYCEYIR PPIDKYKTLA 

      1270       1280       1290       1300       1310       1320 
FGSFDEIRDV GYVFGKNYFE SMAKAGRLGR FNQWFNKEPP KRGNHASLNE YTFIDLAQIV 

      1330       1340       1350       1360       1370       1380 
CKLPETYAVN TAEIFSEDED CDGYISEPST LNTDRRIQVP RAGNSLSLSE AEMDSDVEID 

      1390       1400       1410       1420       1430       1440 
FRSDSKKDKA TQSTPPAPGK DNEDKTDAVD RIPLLTLERP LTDQQQQHSD ETDEQETPRA 

      1450       1460       1470       1480 
MKDGTNTMTT QTTSPTTDAG SEWAGSESEL EKENKNVNTK N 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14030-0811.24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH963925 Genomic DNA. Translation: EDW78358.1.
RefSeqXP_002067372.1. XM_002067336.1.

3D structure databases

ProteinModelPortalB4N1W9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7260.FBpp0245360.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0246868; FBpp0245360; FBgn0218219.
GeneID6644825.
KEGGdwi:Dwil_GK16217.

Organism-specific databases

FlyBaseFBgn0218219. Dwil\GK16217.

Phylogenomic databases

eggNOGCOG0664.
InParanoidB4N1W9.
KOK14676.
OMAMACDRAR.
OrthoDBEOG7QRQT1.
PhylomeDBB4N1W9.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSWS_DROWI
AccessionPrimary (citable) accession number: B4N1W9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase