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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Dwil\GK22213

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dwil\GK22213), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dwil\GK22142), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dwil\GK25101)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Dwil\GK22213Imported
ORF Names:Dwil_GK22213Imported, GK22213Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0224198 Dwil\GK22213

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0251356

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 455FAD_binding_2InterPro annotationAdd BLAST396
Domaini510 – 661Succ_DH_flav_CInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
InParanoidiB4MYF9
KOiK00234
OMAiGDSPWEH
OrthoDBiEOG091G041Z

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

B4MYF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIMRVPSI LAKNAVASMH RVAAVASQRS YHITHGRHQA TAANPDKISK
60 70 80 90 100
QYPIVDHSFD AIVVGAGGAG LRAAFGLVAE GFKTAVITKL FPTRSHTIAA
110 120 130 140 150
QGGINAALGN MEEDDWKWHM YDTVKGSDWL GDQDAIHYMT REAPKAVIEL
160 170 180 190 200
ENYGMPFSRT QDGKIYQRAF GGQSLKFGKG GQAHRCCAVA DRTGHSLLHT
210 220 230 240 250
LYGQSLSYDC NYFVEYFALD LIFEDGECRG VLALNLEDGT LHRFRAQNTV
260 270 280 290 300
MATGGYGRAF FSCTSAHTCT GDGTAMVARQ GLPSQDLEFV QFHPTGIYGA
310 320 330 340 350
GCLITEGCRG EGGYLINSKG ERFMERYAPV AKDLASRDVV SRSMTIEIME
360 370 380 390 400
GRGVGPEKDH VYLQLHHLPP KQLAERLPGI SETAMIFAGV DVTREPIPVL
410 420 430 440 450
PTVHYNMGGI PTNYRGQVIT IDKDGKDVIV PGLYAAGEAA SSSVHGANRL
460 470 480 490 500
GANSLLDLVV FGRACAKTIA EENKPGAPAP KLKDNAGEAS VANLDKLRHA
510 520 530 540 550
NGQITTADLR LKMQKTMQGH AAVFRDGPIL QKGVAKMQEV YKEFKDVKVV
560 570 580 590 600
DKSLIWNSDL VETLELQNLL ANAQMTIVGA EARKESRGAH AREDFKTRID
610 620 630 640 650
EYDYSKPLEG QEKVPVEKHW RKHTLSWVCN DNGDVQLDYR NVIDTTLDNE
660
VSTVPPAIRS Y
Length:661
Mass (Da):72,312
Last modified:September 23, 2008 - v1
Checksum:i9EAD3DE56EE1571C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963894 Genomic DNA Translation: EDW77148.1
CH963894 Genomic DNA Translation: KRF98587.1
RefSeqiXP_002066162.1, XM_002066126.2
XP_015033722.1, XM_015178236.1

Genome annotation databases

EnsemblMetazoaiFBtr0252864; FBpp0251356; FBgn0224198
FBtr0420463; FBpp0378579; FBgn0224198
GeneIDi6643359
KEGGidwi:Dwil_GK22213

Similar proteinsi

Entry informationi

Entry nameiB4MYF9_DROWI
AccessioniPrimary (citable) accession number: B4MYF9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health