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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Dwil\GK22213

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dwil\GK22213), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dwil\GK22142), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dwil\GK25101)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Dwil\GK22213Imported
ORF Names:Dwil_GK22213Imported, GK22213Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0224198. Dwil\GK22213.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0251356.

Structurei

3D structure databases

ProteinModelPortaliB4MYF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiCOG1053.
InParanoidiB4MYF9.
KOiK00234.
OMAiKWRTCFT.
OrthoDBiEOG7MH0XJ.
PhylomeDBiB4MYF9.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4MYF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIMRVPSI LAKNAVASMH RVAAVASQRS YHITHGRHQA TAANPDKISK
60 70 80 90 100
QYPIVDHSFD AIVVGAGGAG LRAAFGLVAE GFKTAVITKL FPTRSHTIAA
110 120 130 140 150
QGGINAALGN MEEDDWKWHM YDTVKGSDWL GDQDAIHYMT REAPKAVIEL
160 170 180 190 200
ENYGMPFSRT QDGKIYQRAF GGQSLKFGKG GQAHRCCAVA DRTGHSLLHT
210 220 230 240 250
LYGQSLSYDC NYFVEYFALD LIFEDGECRG VLALNLEDGT LHRFRAQNTV
260 270 280 290 300
MATGGYGRAF FSCTSAHTCT GDGTAMVARQ GLPSQDLEFV QFHPTGIYGA
310 320 330 340 350
GCLITEGCRG EGGYLINSKG ERFMERYAPV AKDLASRDVV SRSMTIEIME
360 370 380 390 400
GRGVGPEKDH VYLQLHHLPP KQLAERLPGI SETAMIFAGV DVTREPIPVL
410 420 430 440 450
PTVHYNMGGI PTNYRGQVIT IDKDGKDVIV PGLYAAGEAA SSSVHGANRL
460 470 480 490 500
GANSLLDLVV FGRACAKTIA EENKPGAPAP KLKDNAGEAS VANLDKLRHA
510 520 530 540 550
NGQITTADLR LKMQKTMQGH AAVFRDGPIL QKGVAKMQEV YKEFKDVKVV
560 570 580 590 600
DKSLIWNSDL VETLELQNLL ANAQMTIVGA EARKESRGAH AREDFKTRID
610 620 630 640 650
EYDYSKPLEG QEKVPVEKHW RKHTLSWVCN DNGDVQLDYR NVIDTTLDNE
660
VSTVPPAIRS Y
Length:661
Mass (Da):72,312
Last modified:September 23, 2008 - v1
Checksum:i9EAD3DE56EE1571C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963894 Genomic DNA. Translation: EDW77148.1.
RefSeqiXP_002066162.1. XM_002066126.1.

Genome annotation databases

EnsemblMetazoaiFBtr0252864; FBpp0251356; FBgn0224198.
GeneIDi6643359.
KEGGidwi:Dwil_GK22213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963894 Genomic DNA. Translation: EDW77148.1.
RefSeqiXP_002066162.1. XM_002066126.1.

3D structure databases

ProteinModelPortaliB4MYF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0251356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0252864; FBpp0251356; FBgn0224198.
GeneIDi6643359.
KEGGidwi:Dwil_GK22213.

Organism-specific databases

FlyBaseiFBgn0224198. Dwil\GK22213.

Phylogenomic databases

eggNOGiCOG1053.
InParanoidiB4MYF9.
KOiK00234.
OMAiKWRTCFT.
OrthoDBiEOG7MH0XJ.
PhylomeDBiB4MYF9.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiB4MYF9_DROWI
AccessioniPrimary (citable) accession number: B4MYF9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.