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Protein

Histone-lysine N-methyltransferase

Gene

Dwil\GK20252

Organism
Drosophila willistoni (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:Dwil\GK20252Imported
ORF Names:Dwil_GK20252Imported, GK20252Imported
OrganismiDrosophila willistoni (Fruit fly)Imported
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0222249. Dwil\GK20252.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7260.FBpp0249395.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1407 – 145145AWSInterPro annotationAdd
BLAST
Domaini1454 – 1570117SETInterPro annotationAdd
BLAST
Domaini1578 – 159417Post-SETInterPro annotationAdd
BLAST
Domaini1994 – 2132139BAHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1052 – 107221Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiCOG2940. LUCA.
KOG1083. Eukaryota.
InParanoidiB4MXM5.
KOiK06101.
OMAiQCERCEP.
OrthoDBiEOG7ZPNJ4.
PhylomeDBiB4MXM5.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4MXM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSDQNGATR AADKTKDQEQ QNPGPGPETG GSENEETTDT SQSQTQSIKS
60 70 80 90 100
SATQFSVVQR TDTDGLRMRI SAIRPLAPPP SLKTNCKMST TTTDSLSCFR
110 120 130 140 150
QEEITTNKSN KTSKKIKVKR KKLSHTDAVN PSKVRKSGGV AAASMGGIFS
160 170 180 190 200
SDSDDDLPLK VHQQRAPRLL LTAIAGHQAS GQAPPPPDSI GISSSDNELP
210 220 230 240 250
SLVQAAIKRV ESDTEDTSVS LGATGKSKHL PQYQSTLLQD FMEKTQMLGQ
260 270 280 290 300
HQLVGGGDRV KPKEETQPPA NPRKRRGRPK KLNPHIGSNL RAGSVVTARP
310 320 330 340 350
AAVNESADSG VISTTSTTQS TTPSPKMPNS SDPPQAQARG LDSAAGNSST
360 370 380 390 400
KIDMSYLDKR MYATERVLYP PPRNKRRQIK NPKNIKDAEQ VDPLWREIDV
410 420 430 440 450
NKKFRLRSMS VGASGGGGGS GRGGSGGVAS AICSKVLVAN SGYVSDYGSV
460 470 480 490 500
RHPHSSHSRS NHNSGYKSDA SCKSRYSVKS CVSRRSRAKS CGYRSDCKEG
510 520 530 540 550
GKSSIRLRRR RRPSTMIATT ADVEDQDILQ LAGLSLGQSS EESNEYISKP
560 570 580 590 600
SLQSLPSTSA SKKYGEINRY ITTGQYFSRE PNPSQNQNQP EAPFMSKMLL
610 620 630 640 650
NHRKDSSQAA SNAQSSCRFP CKIKSRRSSA ASMCSSYVSG VSRMLRRRHR
660 670 680 690 700
RNKSLQIDSK LLTEIEILTS TFHGRCRIQE DRLTGSSGKE KLLAEATKLK
710 720 730 740 750
ATTLNAAAPA STLAQPLKRA MKKRKLSEPL VDFAMLSASA NANGDGVGGA
760 770 780 790 800
SNAQSSGAGS SKRRHKKSQG SSTSSSPDDH KLPLKKRHYL LTPGERPPAD
810 820 830 840 850
SSNFANGKLN AEAWAAAAAT AKTTASTKSQ AQFNARSAKS LLTPKKRHLL
860 870 880 890 900
EHQSGGVTTT SASNSPLRIV VDSNSSISGG KLLDISPSSL GSLKQQKRAS
910 920 930 940 950
VASSNKQKRD PATQLHSPAP SGSGSCPPPP PGIFEPSVEL EIQIPLSKLN
960 970 980 990 1000
ESVIITKSEV ASPLLSLDIK EDTKKEMGQR VVESLLHKTG GNLLFKRKRK
1010 1020 1030 1040 1050
KINRTGFPTV RRKKRKVSLE QLQTEKSSEQ MDQEQEQQEQ DPLSRETRST
1060 1070 1080 1090 1100
NSNNPVQNCE RVPLVGEARE TFVARSNARM TPRLSVVALE RLQRPQTPSR
1110 1120 1130 1140 1150
GRPRGRKPKD KLEQVTESSA VASSAPPPPP PSEKTVAKKR GRRQVAKPEE
1160 1170 1180 1190 1200
EQEPAIAIPT PAKNKLLVEP NIKLPAGVDP NTNFSCKIRL KRRRNLEEIT
1210 1220 1230 1240 1250
SKEIVSQEEL DKEAEAKRLD VIPSEHDPLP MQECTSSSTL AIHSQQDYAS
1260 1270 1280 1290 1300
CSESSEDKLS TASRNKISKL KKNYLVAGLL SNYYKQATKP PPVKHQGGGK
1310 1320 1330 1340 1350
DSIAPSSGQR LMPPPPYCER YHRRTQIDFE LPYDIWWAYT NAKLPLRHQV
1360 1370 1380 1390 1400
PSWNYRKIRT NVYAESVRPN LAGFDHPVCN CKESCMDNCL NRMVYTECSA
1410 1420 1430 1440 1450
TNCPSGDKCH NQKIHRHEVA PGVERFMTAD KGWGVRTKLP IAKGTYILEY
1460 1470 1480 1490 1500
VGEVVTEREF KQRMASIYLN DTHHYCLHLD GGLVIDGQRM GSDCRFVNHS
1510 1520 1530 1540 1550
CEPNCEMQKW SVNGLSRMVL FAKRQIRQGE ELTYDYNFSL FNPSEGQPCR
1560 1570 1580 1590 1600
CGMPQCRGVI GGKSQRVKPL PPIAAVSADA SPQRGGRQRK HKAKKHPQKG
1610 1620 1630 1640 1650
GTAAGGSGSM PLVNKLVQQL SERERKLAKQ FNVFLVRNYE KIRRYKVKRS
1660 1670 1680 1690 1700
HKASSAIGAS AASTSQGSLG GRRPSTPSSS SLLAAQISAL CTPRNIKTRG
1710 1720 1730 1740 1750
LAQAVQDPEL EKMARMAVVL RDICQTIEGM NMTEILSLSA AACKQSKRKN
1760 1770 1780 1790 1800
AKNTNSAVSS SSSSSSTTAG ALQAGRLEFK GIQSMVEQGH YKSPQEFDAH
1810 1820 1830 1840 1850
MQQLFDEARK TYTDDESKIN LLQSLVECYE QQKVSSYEQL VEILGDSVDL
1860 1870 1880 1890 1900
HGFKAKQVEP QPTVEPAIKE TQITPLPPPV ATDDEDVISC ICGLYKDEGL
1910 1920 1930 1940 1950
MIQCSKCMVW QHTECTKADI NAENYQCERC EPRKVDREIP LDEFTEEGHR
1960 1970 1980 1990 2000
YYLSLMRGND LQVRQGDAVY VLRDIPIKDN EEQKKHTYET IGKIDYQECD
2010 2020 2030 2040 2050
IFRVEHLWKN ETGKRFIFGH HFLRPHETFH EPTRRFYPNE VVRVSLYEVV
2060 2070 2080 2090 2100
PIELVIGRCW VLDRTTFCKG RPIECHDESH CYICELRVDK SARFFSKTKA
2110 2120 2130 2140 2150
SYPACTKSYA FRKFPERVKI SKTYAPHDVD ASMLKTKKQK TELEVATTAK
2160 2170 2180 2190 2200
QQRITVREGR RRQPRTAEPS YVATKSIGGV GTSNATAAVQ VLTPTLPNGQ
2210 2220 2230 2240 2250
LLKRKRSRLE NVLITMKLKC LDAQTAQEQP IDLSYLLSGR GARQRKTNNN
2260
QTTTTSDLGH N
Length:2,261
Mass (Da):249,718
Last modified:January 20, 2016 - v2
Checksum:i424049FE988AFC15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963876 Genomic DNA. Translation: EDW76794.2.
RefSeqiXP_002065808.1. XM_002065772.1.

Genome annotation databases

EnsemblMetazoaiFBtr0250903; FBpp0249395; FBgn0222249.
GeneIDi6643058.
KEGGidwi:Dwil_GK20252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963876 Genomic DNA. Translation: EDW76794.2.
RefSeqiXP_002065808.1. XM_002065772.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0249395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0250903; FBpp0249395; FBgn0222249.
GeneIDi6643058.
KEGGidwi:Dwil_GK20252.

Organism-specific databases

FlyBaseiFBgn0222249. Dwil\GK20252.

Phylogenomic databases

eggNOGiCOG2940. LUCA.
KOG1083. Eukaryota.
InParanoidiB4MXM5.
KOiK06101.
OMAiQCERCEP.
OrthoDBiEOG7ZPNJ4.
PhylomeDBiB4MXM5.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24Imported.

Entry informationi

Entry nameiB4MXM5_DROWI
AccessioniPrimary (citable) accession number: B4MXM5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: January 20, 2016
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.