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B4MSP6 (B4MSP6_DROWI) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548
Gene names
Name:GK19859 FlyBase FBgn0221857
Synonyms:Dwil\GK19859 EMBL EDW75135.1
ORF Names:Dwil_GK19859 EMBL EDW75135.1
OrganismDrosophila willistoni (Fruit fly) [Complete proteome]
Taxonomic identifier7260 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548

Cofactor

NAD By similarity. RuleBase RU000548

Pathway

Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548

Sequence similarities

Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
   Biological processOne-carbon metabolism RuleBase RU000548
   LigandNAD RuleBase RU000548
   Molecular functionHydrolase RuleBase RU000548
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site561Substrate By similarity PIRSR PIRSR001109-1
Binding site1311Substrate By similarity PIRSR PIRSR001109-1
Binding site1561Substrate By similarity PIRSR PIRSR001109-1
Binding site1861Substrate By similarity PIRSR PIRSR001109-1
Binding site1901Substrate By similarity PIRSR PIRSR001109-1

Sequences

Sequence LengthMass (Da)Tools
B4MSP6 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 98E802B539C908D9

FASTA43247,308
        10         20         30         40         50         60 
MSKPAYKVAD ISLAEWGRKA IIIAENEMPG LMACRKKYGP SKILKGARIT GCLHMTVQTA 

        70         80         90        100        110        120 
VLIETLVELG AEVQWSSCNI FSTQDNAAAA IAATGVPVYA WKGETEEEYL WCIEQTLVFP 

       130        140        150        160        170        180 
DGQPLNMILD DGGDLTNLVH EKFPQYLKGI KGLSEETTTG VHNLYKMFKE GRLGVPAINV 

       190        200        210        220        230        240 
NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVCCVAG YGDVGKGCAQ ALKGFGGRVI 

       250        260        270        280        290        300 
VTEIDPINAL QAAMEGYEVT TMEEASKEAS IYVTTTGCRD IITSEHLLQM PDDSIVCNIG 

       310        320        330        340        350        360 
HFDCEIDVDW LNANAKVKVN VKPQVDRYTM PNGRHIIVLA EGRLVNLGCA HGHPSFVMSN 

       370        380        390        400        410        420 
SFTNQVLAQI ELFTKSDQYT VGVHVLPKLL DEEVASLHLE KLGVKLTKLT EKQAAYLGVP 

       430 
QTGPFKPDHY RY

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed: 17994087] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14030-0811.24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH963851 Genomic DNA. Translation: EDW75135.1.
RefSeqXP_002064149.1. XM_002064113.1.

3D structure databases

ProteinModelPortalB4MSP6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4MSP6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0250510; FBpp0249002; FBgn0221857.
GeneID6641149.
KEGGdwi:Dwil_GK19859.

Organism-specific databases

FlyBaseFBgn0221857. Dwil\GK19859.

Phylogenomic databases

GeneTreeEMGT00050000015433.
InParanoidB4MSP6.
OMASAQVWVT.
OrthoDBEOG45DV4T.
PhylomeDBB4MSP6.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4MSP6_DROWI
AccessionPrimary (citable) accession number: B4MSP6
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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