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B4MLR8

- UBP36_DROWI

UniProt

B4MLR8 - UBP36_DROWI

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Protein
Ubiquitin carboxyl-terminal hydrolase 36
Gene
Usp36, scny, GK17299
Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei221 – 2211Nucleophile By similarity
Active sitei492 – 4921Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GK17299
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0219298. Dwil\GK17299.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13111311Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei581 – 5811Phosphoserine By similarity
Modified residuei767 – 7671Phosphothreonine By similarity
Modified residuei787 – 7871Phosphoserine By similarity
Modified residuei789 – 7891Phosphoserine By similarity
Modified residuei982 – 9821Phosphoserine By similarity
Modified residuei985 – 9851Phosphothreonine By similarity
Modified residuei988 – 9881Phosphoserine By similarity
Modified residuei1047 – 10471Phosphoserine By similarity
Modified residuei1050 – 10501Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Protein-protein interaction databases

STRINGi7260.FBpp0246442.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 533322USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiB4MLR8.
KOiK11855.
OMAiENEMDRG.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4MLR8.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4MLR8-1 [UniParc]FASTAAdd to Basket

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MPVSLAVCET TTTTTANVVN AALRESLLGG SRSGAAVAGS GSASSLISGA     50
GGAGASAAND DDSSSTATAN TNLQNQIVAS AKRVLLAKIE YEEVENYNDS 100
VLDNLKTKYV VIKSPTPAAA AAATNNGNSN SAGSKILGAN GHDNRQKQQN 150
ANGGCSTPTT TTTQTSSSST SSSSIEHNNN PNELPKPKRV LYQRENIRIG 200
WKQSERKWQI GAGMINVGNT CYLNSTLQAL FHIPALANWL NSEQSHLENC 250
NIGGESGGGG GGGGGNNGGF CIICAMAKTL QSTQSNASAI RPYHIYSKLK 300
QICKHMVIGR QEDAHEFLRF LVEAMEKAYL MRYRNYKELD QLVKETTPLN 350
QIFGGYLRSE VRCLSCNHVS ITFQHFQDLL LDIRKSDTLD EAFDGYFSRE 400
RLEDMGYKCE GCKKKVSATK QFSLQRAPIT LCIQLKRFSM IGNKLTKQIS 450
FKPRIDLSRF AARSPTAQGQ LPLTYRLVSL VTHLGVSQHC GHYTAIGLTE 500
SGSYYNFDDS YVRPIAMQSV CSTNSYIMFY ELDLNQPLAT PANKLNGLRQ 550
LSNGHHHHQQ QQQQHQQQQQ QQPTVVATIA SSPMATTRFI GPQLPPGGLN 600
GYAMTTTTTA TNNTTNGHSQ KTAIQFKPQQ NGILTVGSGK FQESGQQKSP 650
LVGTNHKNEA PAVAPNANAN ANGKSSSNPN TNTTINTNTN NGNSNNNNTN 700
ATTANNSNKL NQQQQQYLPM SSSDEEDSDE EKMKRPTTTT PQLPSMPKMD 750
GGGDEKPKTL TLTPTTTPTA STPTVSNPLK RLVPYESASE EEESSSGTPS 800
SSTPTTTTTA AAAAASSPMQ ATAAATLPPP PTPTNARKRS LPDHHHHHPH 850
HHVMVNGHGK SPKPASMPPA TNFNSSSSKQ KTDAIDEIFK SLNNFNKKRI 900
NNKNQKHNEG DEEEDDEETL EKETNNSSRL VSSSTNTSPT TNGWKQSQIV 950
SSSSSNSKNV STSAAAAAAT TSSSTSTSAP PSPKTPPSPA VINSKTGLWK 1000
VTRNLDDDDD EEEEDEDDEE HIAPTPPPVV AKTHKNPFSS QQKPTPSPST 1050
EAAPKRQKLF NGTSSSTPHV GNGYQSEPST PNGGGSGSGS NGCLNELLKQ 1100
SHRGYGSSSV LSWNGKQTEL DKEPFELVCA KRIAVDHGDH DDGGGGDDGG 1150
GVGVVTTTTT TTTTTKNTTK TLTADAQEQR QRDLDDDEEN EMDRGRQRKV 1200
KTATANGKSS GNSNNTTPGY NPFQEYESQK RWHNKSSNGP PRFYTQHASS 1250
SYRSNFHQRN KFKCNRGGNG GGGSGGISKF DHRHGLQRHL AAGGGFPRRP 1300
NANQQQQQQQ S 1311
Length:1,311
Mass (Da):141,002
Last modified:September 23, 2008 - v1
Checksum:i408909EBD862A2ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963847 Genomic DNA. Translation: EDW72994.1.
RefSeqiXP_002062008.1. XM_002061972.1.

Genome annotation databases

EnsemblMetazoaiFBtr0247950; FBpp0246442; FBgn0219298.
GeneIDi6638806.
KEGGidwi:Dwil_GK17299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH963847 Genomic DNA. Translation: EDW72994.1 .
RefSeqi XP_002062008.1. XM_002061972.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0246442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0247950 ; FBpp0246442 ; FBgn0219298 .
GeneIDi 6638806.
KEGGi dwi:Dwil_GK17299.

Organism-specific databases

FlyBasei FBgn0219298. Dwil\GK17299.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi B4MLR8.
KOi K11855.
OMAi ENEMDRG.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4MLR8.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24.

Entry informationi

Entry nameiUBP36_DROWI
AccessioniPrimary (citable) accession number: B4MLR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi