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B4MLR8

- UBP36_DROWI

UniProt

B4MLR8 - UBP36_DROWI

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei221 – 2211NucleophilePROSITE-ProRule annotation
Active sitei492 – 4921Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GK17299
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007798: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0219298. Dwil\GK17299.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13111311Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei581 – 5811PhosphoserineBy similarity
Modified residuei767 – 7671PhosphothreonineBy similarity
Modified residuei787 – 7871PhosphoserineBy similarity
Modified residuei789 – 7891PhosphoserineBy similarity
Modified residuei982 – 9821PhosphoserineBy similarity
Modified residuei985 – 9851PhosphothreonineBy similarity
Modified residuei988 – 9881PhosphoserineBy similarity
Modified residuei1047 – 10471PhosphoserineBy similarity
Modified residuei1050 – 10501PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Protein-protein interaction databases

STRINGi7260.FBpp0246442.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 533322USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiB4MLR8.
KOiK11855.
OMAiENEMDRG.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4MLR8.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4MLR8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSLAVCET TTTTTANVVN AALRESLLGG SRSGAAVAGS GSASSLISGA
60 70 80 90 100
GGAGASAAND DDSSSTATAN TNLQNQIVAS AKRVLLAKIE YEEVENYNDS
110 120 130 140 150
VLDNLKTKYV VIKSPTPAAA AAATNNGNSN SAGSKILGAN GHDNRQKQQN
160 170 180 190 200
ANGGCSTPTT TTTQTSSSST SSSSIEHNNN PNELPKPKRV LYQRENIRIG
210 220 230 240 250
WKQSERKWQI GAGMINVGNT CYLNSTLQAL FHIPALANWL NSEQSHLENC
260 270 280 290 300
NIGGESGGGG GGGGGNNGGF CIICAMAKTL QSTQSNASAI RPYHIYSKLK
310 320 330 340 350
QICKHMVIGR QEDAHEFLRF LVEAMEKAYL MRYRNYKELD QLVKETTPLN
360 370 380 390 400
QIFGGYLRSE VRCLSCNHVS ITFQHFQDLL LDIRKSDTLD EAFDGYFSRE
410 420 430 440 450
RLEDMGYKCE GCKKKVSATK QFSLQRAPIT LCIQLKRFSM IGNKLTKQIS
460 470 480 490 500
FKPRIDLSRF AARSPTAQGQ LPLTYRLVSL VTHLGVSQHC GHYTAIGLTE
510 520 530 540 550
SGSYYNFDDS YVRPIAMQSV CSTNSYIMFY ELDLNQPLAT PANKLNGLRQ
560 570 580 590 600
LSNGHHHHQQ QQQQHQQQQQ QQPTVVATIA SSPMATTRFI GPQLPPGGLN
610 620 630 640 650
GYAMTTTTTA TNNTTNGHSQ KTAIQFKPQQ NGILTVGSGK FQESGQQKSP
660 670 680 690 700
LVGTNHKNEA PAVAPNANAN ANGKSSSNPN TNTTINTNTN NGNSNNNNTN
710 720 730 740 750
ATTANNSNKL NQQQQQYLPM SSSDEEDSDE EKMKRPTTTT PQLPSMPKMD
760 770 780 790 800
GGGDEKPKTL TLTPTTTPTA STPTVSNPLK RLVPYESASE EEESSSGTPS
810 820 830 840 850
SSTPTTTTTA AAAAASSPMQ ATAAATLPPP PTPTNARKRS LPDHHHHHPH
860 870 880 890 900
HHVMVNGHGK SPKPASMPPA TNFNSSSSKQ KTDAIDEIFK SLNNFNKKRI
910 920 930 940 950
NNKNQKHNEG DEEEDDEETL EKETNNSSRL VSSSTNTSPT TNGWKQSQIV
960 970 980 990 1000
SSSSSNSKNV STSAAAAAAT TSSSTSTSAP PSPKTPPSPA VINSKTGLWK
1010 1020 1030 1040 1050
VTRNLDDDDD EEEEDEDDEE HIAPTPPPVV AKTHKNPFSS QQKPTPSPST
1060 1070 1080 1090 1100
EAAPKRQKLF NGTSSSTPHV GNGYQSEPST PNGGGSGSGS NGCLNELLKQ
1110 1120 1130 1140 1150
SHRGYGSSSV LSWNGKQTEL DKEPFELVCA KRIAVDHGDH DDGGGGDDGG
1160 1170 1180 1190 1200
GVGVVTTTTT TTTTTKNTTK TLTADAQEQR QRDLDDDEEN EMDRGRQRKV
1210 1220 1230 1240 1250
KTATANGKSS GNSNNTTPGY NPFQEYESQK RWHNKSSNGP PRFYTQHASS
1260 1270 1280 1290 1300
SYRSNFHQRN KFKCNRGGNG GGGSGGISKF DHRHGLQRHL AAGGGFPRRP
1310
NANQQQQQQQ S
Length:1,311
Mass (Da):141,002
Last modified:September 23, 2008 - v1
Checksum:i408909EBD862A2ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963847 Genomic DNA. Translation: EDW72994.1.
RefSeqiXP_002062008.1. XM_002061972.1.

Genome annotation databases

EnsemblMetazoaiFBtr0247950; FBpp0246442; FBgn0219298.
GeneIDi6638806.
KEGGidwi:Dwil_GK17299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963847 Genomic DNA. Translation: EDW72994.1 .
RefSeqi XP_002062008.1. XM_002061972.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7260.FBpp0246442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0247950 ; FBpp0246442 ; FBgn0219298 .
GeneIDi 6638806.
KEGGi dwi:Dwil_GK17299.

Organism-specific databases

FlyBasei FBgn0219298. Dwil\GK17299.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi B4MLR8.
KOi K11855.
OMAi ENEMDRG.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4MLR8.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14030-0811.24.

Entry informationi

Entry nameiUBP36_DROWI
AccessioniPrimary (citable) accession number: B4MLR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3