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Protein

Histone deacetylase

Gene

Rpd3

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:Rpd3Imported
Synonyms:Dvir\GJ15512Imported
ORF Names:Dvir_GJ15512Imported, GJ15512Imported
OrganismiDrosophila virilis (Fruit fly)Imported
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0202705. Dvir\Rpd3.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0229929.

Structurei

3D structure databases

ProteinModelPortaliB4MFY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0123.
InParanoidiB4MFY7.
KOiK06067.
OMAiACPSPRD.
OrthoDBiEOG7DNNTW.
PhylomeDBiB4MFY7.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

B4MFY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSHSKKRVC YYYDSDIGNY YYGQGHPMKP HRIRMTHNLL LNYGLYRKME
60 70 80 90 100
IYRPHKATAD EMTKFHSDEY VRFLRSIRPD NMTEYNKQMQ RFNVGEDCPV
110 120 130 140 150
FDGLYEFCQL SAGGSVAAAV KLNKQASEIC INWGGGLHHA KKSEASGFCY
160 170 180 190 200
VNDIVLGILE LLKYHQRVLY IDIDVHHGDG VEEAFYTTDR VMTVSFHKYG
210 220 230 240 250
EYFPGTGDLR DIGAGKGKYY AVNIPLRDGM DDDAYESIFV PIISKVMETF
260 270 280 290 300
QPAAVVLQCG ADSLTGDRLG CFNLTVKGHG KCVEFVKKYN LPFLMVGGGG
310 320 330 340 350
YTIRNVSRCW TYETSVALAV EIANELPYND YFEYFGPDFK LHISPSNMTN
360 370 380 390 400
QNTAEYLEKI KSRLFENLRM LPHAPGVQIQ AIPEDAINDE SEDEDKVDKD
410 420 430 440 450
ERLPQSDKDK RIVPENEYSD SEDEGEAGRR DNRTYKGQRK RPRLDKEPII
460 470 480 490 500
TNSSNKTSSE TSSDIKDDKE KADGVDGEET PTANSNNNNN NNSSNSSSSN
510 520
NNKGDNDAST NAGGASSASK GAKENNI
Length:527
Mass (Da):59,298
Last modified:September 23, 2008 - v1
Checksum:iBB1D7E0571C1C714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940669 Genomic DNA. Translation: EDW58248.1.
RefSeqiXP_002060037.1. XM_002060001.1.

Genome annotation databases

EnsemblMetazoaiFBtr0231437; FBpp0229929; FBgn0202705.
GeneIDi6636600.
KEGGidvi:Dvir_GJ15512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940669 Genomic DNA. Translation: EDW58248.1.
RefSeqiXP_002060037.1. XM_002060001.1.

3D structure databases

ProteinModelPortaliB4MFY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0229929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0231437; FBpp0229929; FBgn0202705.
GeneIDi6636600.
KEGGidvi:Dvir_GJ15512.

Organism-specific databases

FlyBaseiFBgn0202705. Dvir\Rpd3.

Phylogenomic databases

eggNOGiCOG0123.
InParanoidiB4MFY7.
KOiK06067.
OMAiACPSPRD.
OrthoDBiEOG7DNNTW.
PhylomeDBiB4MFY7.

Miscellaneous databases

ChiTaRSiRpd3. fly.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87Imported.

Entry informationi

Entry nameiB4MFY7_DROVI
AccessioniPrimary (citable) accession number: B4MFY7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 4, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.