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B4MFY7

- B4MFY7_DROVI

UniProt

B4MFY7 - B4MFY7_DROVI

Protein

Histone deacetylase

Gene

Rpd3

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    Name:Rpd3Imported
    Synonyms:Dvir\GJ15512Imported
    ORF Names:Dvir_GJ15512Imported, GJ15512Imported
    OrganismiDrosophila virilis (Fruit fly)Imported
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0202705. Dvir\Rpd3.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi7244.FBpp0229929.

    Structurei

    3D structure databases

    ProteinModelPortaliB4MFY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0123.
    InParanoidiB4MFY7.
    KOiK06067.
    OMAiASWCRCH.
    OrthoDBiEOG7DNNTW.
    PhylomeDBiB4MFY7.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    B4MFY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSHSKKRVC YYYDSDIGNY YYGQGHPMKP HRIRMTHNLL LNYGLYRKME    50
    IYRPHKATAD EMTKFHSDEY VRFLRSIRPD NMTEYNKQMQ RFNVGEDCPV 100
    FDGLYEFCQL SAGGSVAAAV KLNKQASEIC INWGGGLHHA KKSEASGFCY 150
    VNDIVLGILE LLKYHQRVLY IDIDVHHGDG VEEAFYTTDR VMTVSFHKYG 200
    EYFPGTGDLR DIGAGKGKYY AVNIPLRDGM DDDAYESIFV PIISKVMETF 250
    QPAAVVLQCG ADSLTGDRLG CFNLTVKGHG KCVEFVKKYN LPFLMVGGGG 300
    YTIRNVSRCW TYETSVALAV EIANELPYND YFEYFGPDFK LHISPSNMTN 350
    QNTAEYLEKI KSRLFENLRM LPHAPGVQIQ AIPEDAINDE SEDEDKVDKD 400
    ERLPQSDKDK RIVPENEYSD SEDEGEAGRR DNRTYKGQRK RPRLDKEPII 450
    TNSSNKTSSE TSSDIKDDKE KADGVDGEET PTANSNNNNN NNSSNSSSSN 500
    NNKGDNDAST NAGGASSASK GAKENNI 527
    Length:527
    Mass (Da):59,298
    Last modified:September 23, 2008 - v1
    Checksum:iBB1D7E0571C1C714
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940669 Genomic DNA. Translation: EDW58248.1.
    RefSeqiXP_002060037.1. XM_002060001.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0231437; FBpp0229929; FBgn0202705.
    GeneIDi6636600.
    KEGGidvi:Dvir_GJ15512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940669 Genomic DNA. Translation: EDW58248.1 .
    RefSeqi XP_002060037.1. XM_002060001.1.

    3D structure databases

    ProteinModelPortali B4MFY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0229929.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0231437 ; FBpp0229929 ; FBgn0202705 .
    GeneIDi 6636600.
    KEGGi dvi:Dvir_GJ15512.

    Organism-specific databases

    FlyBasei FBgn0202705. Dvir\Rpd3.

    Phylogenomic databases

    eggNOGi COG0123.
    InParanoidi B4MFY7.
    KOi K06067.
    OMAi ASWCRCH.
    OrthoDBi EOG7DNNTW.
    PhylomeDBi B4MFY7.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87Imported.

    Entry informationi

    Entry nameiB4MFY7_DROVI
    AccessioniPrimary (citable) accession number: B4MFY7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3