Dvir\GJ15764

Functionⁱ

Catalytic activityⁱ

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functionⁱ

histone methyltransferase activity (H4-K20 specific) Source: UniProtKB-UniRule

Complete GO annotation...

GO - Biological processⁱ

histone H4-K20 trimethylation Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Molecular function	MethyltransferasePROSITE-ProRule annotation, Transferase
Ligand	S-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesⁱ	Name:Dvir\GJ15764Imported ORF Names:Dvir_GJ15764Imported, GJ15764Imported
Organismⁱ	Drosophila virilis (Fruit fly)Imported
Taxonomic identifierⁱ	7244 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Drosophila › virilis group
Proteomesⁱ	UP000008792 Componentⁱ: Unassembled WGS sequence

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0202952. Dvir\GJ15764.

FlyBaseⁱ

FBgn0202952. Dvir\GJ15764.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	184 – 295	SETInterPro annotationAdd BLAST		112

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	840 – 880	Sequence analysisAdd BLAST		41

Sequence similaritiesⁱ

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG2589. Eukaryota. ENOG410XPH8. LUCA.
InParanoidⁱ	B4MA08.
KEGG Orthology (KO) More...KOⁱ	K11429.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IUY.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025790. Hist-Lys_N-MTase_Suvar4-20. IPR001214. SET_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00856. SET. 1 hit.
SMARTⁱ	View protein in SMART SM00317. SET. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51570. SAM_MT43_SUVAR420_2. 1 hit. PS50280. SET. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B4MA08-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVVGSNHTRR SETAGRYTNS SSSSNNNNTN SSGSNNNNNN TTTTTTTTSH 
        60         70         80         90        100
GGSSGTVHVA VGSLNGCNGS AVSRLSQSTG MSPRELSEND DLATSLILDP 
       110        120        130        140        150
HLGFQTHKMN IRFRPLKVDT QQLKAIVDEF IHTQNYDIAI QRIYDGPWIP 
       160        170        180        190        200
RHLKNKNKIA TKRLHDHIVR YLRVFDKDSG FAIEACYRYS LEEQRGAKIS 
       210        220        230        240        250
STKRWSKNDK IECLVGCIAE LTEAEEAALL HSGKNDFSVM YSCRKNCAQL 
       260        270        280        290        300
WLGPAAYINH DCRANCKFLA TGRDTACVKV LRDIEVGEEI TCFYGEDFFG 
       310        320        330        340        350
DSNRYCECET CERRGTGAFA GKHSANQLNE AMLGLTNGLG LGLGLGAAGG 
       360        370        380        390        400
ANGGGYRLRE TDNRINRIKS RANSTNSTSN SNSNDSSSNN TAQPHNNNSS 
       410        420        430        440        450
GSNNNNNNNN SSSIAAVAQT VAAVRPKSSS LELNAVALMD KKLPNVVVSP 
       460        470        480        490        500
LTMKELRQKG MTKYDAEMIM ANAAYHQQQQ QQHHHHHHHH HHQHQHQGHS 
       510        520        530        540        550
SSSSNNAEAA SQATAMQKPQ QAAAELSNGR GISTLRKSMR VNSTSSSIST 
       560        570        580        590        600
ASTDEPPLAS YAATGAAATT TTVAAIAKAP VVLVPRYKPA ANNNNSSSSS 
       610        620        630        640        650
NNIKTTITNC NNLNISNSCR NNVSARFSER KLKPSEPAPA ATTTTASLAN 
       660        670        680        690        700
LAVPSSSNCS PGEQQQQLQQ QQQHQKQQQA AATTTTTAAA TATTSAAATT 
       710        720        730        740        750
SGSSAVEPLL KTPERRLKLT LRMKRSPILD EVFELGTSLG EDRQHAQQNG 
       760        770        780        790        800
HAANRASQAH SSSSSSGGGS GGAGGRNSSN NVGAGGNSSN SNNNALHNAS 
       810        820        830        840        850
SSSSGGIEYE ILRMEGISEH GNDDDEEDEE EEEEDDDDDD DDEEAEEEEE 
       860        870        880        890        900
EQELNEEEGL ELEQEQLQQL KQQQLKQQQQ QQHHHPEASG SDASDWRYTE 
       910        920        930        940        950
KTRRSRRSAQ SAASTPPPPQ VASSSSSSNI YGTPQKKRLR LIFGNESHTI 
       960        970        980        990       1000
DIPPASTTAT VAAAAATVGS GIDELNSSGG GDGGGDESFN ASYASSSSSS 
      1010       1020       1030       1040       1050
GANGSGSGTS MTVNTSSLNS TPTSSASLEL EAATTTTSAA AAAAATSRAA 
      1060       1070       1080       1090       1100
TGTGTGTRLP AADSPTSTTS SVGSFQSACT STTNFFTRSK SPSSSNSYQL 
      1110       1120 
NGSRSNSSNY MPYYQLVNDE AK

Length:1,122

Mass (Da):119,194

Last modified:January 20, 2016 - v2

Checksum:ⁱ65FD9CF049A83AC6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH940655 Genomic DNA. Translation: EDW66067.2.
NCBI Reference Sequences More...RefSeqⁱ	XP_002057959.2. XM_002057923.2.

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0231689; FBpp0230181; FBgn0202952.
GeneIDⁱ	6634530.
KEGGⁱ	dvi:Dvir_GJ15764.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH940655 Genomic DNA. Translation: EDW66067.2.
NCBI Reference Sequences More...RefSeqⁱ	XP_002057959.2. XM_002057923.2.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0231689; FBpp0230181; FBgn0202952.
GeneIDⁱ	6634530.
KEGGⁱ	dvi:Dvir_GJ15764.

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0202952. Dvir\GJ15764.

FlyBaseⁱ

FBgn0202952. Dvir\GJ15764.

Phylogenomic databases

eggNOGⁱ	KOG2589. Eukaryota. ENOG410XPH8. LUCA.
InParanoidⁱ	B4MA08.
KEGG Orthology (KO) More...KOⁱ	K11429.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IUY.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025790. Hist-Lys_N-MTase_Suvar4-20. IPR001214. SET_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00856. SET. 1 hit.
SMARTⁱ	View protein in SMART SM00317. SET. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51570. SAM_MT43_SUVAR420_2. 1 hit. PS50280. SET. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4MA08_DROVI
Accessionⁱ	B4MA08Primary (citable) accession number: B4MA08
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 23, 2008
	Last sequence update:	January 20, 2016
	Last modified:	July 5, 2017
	This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - B4MA08 (B4MA08_DROVI)

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Histone-lysine N-methyltransferase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B4MA08 (B4MA08_DROVI)

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Histone-lysine N-methyltransferase

Dvir\GJ15764

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ